Protein: CGRF1
Cell growth regulator with RING finger domain protein 1 (Cell growth regulatory gene 19 protein) (RING finger protein 197)

Gene: CGRF1, CGRRF1
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q99675

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005783 - endoplasmic reticulum
GO:0008270 - zinc ion binding
GO:0008285 - negative regulation of cell population proliferation
GO:0030308 - negative regulation of cell growth

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1372378

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

3

1

High-throughput

0.667

High

1085467

SRBP2
Sterol regulatory element-binding protein 2

3

0

High-throughput

0.638

High

1353414

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

3

0

High-throughput

0.638

High

1406327

CC50A
Cell cycle control protein 50A

3

0

High-throughput

0.638

High

944927

TMPS3
Transmembrane protease serine 3

2

2

High-throughput

0.628

High

251408

FOXD2
Forkhead box protein D2

3

1

High-throughput

0.609

High

1310933

ZNT8
Proton-coupled zinc antiporter SLC30A8

2

1

High-throughput

0.606

High

829919

PMEL
Melanocyte protein PMEL

2

0

High-throughput

0.602

High

1198745

MPPE1
Metallophosphoesterase 1

2

0

High-throughput

0.602

High

1359081

TMED6
Transmembrane emp24 domain-containing protein 6

2

0

High-throughput

0.602

High

1359349

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

0

High-throughput

0.602

High

1388946

ARSG
Arylsulfatase G

2

0

High-throughput

0.602

High

1136676

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.586

High

61136

T131L
Transmembrane protein 131-like

2

0

High-throughput

0.585

High

1394593

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

0

High-throughput

0.585

High

1218747

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

0

High-throughput

0.584

High

180026

BET1
BET1 homolog

2

0

High-throughput

0.580

High

209099

CYB5B
Cytochrome b5 type B

2

0

High-throughput

0.580

High

327423

ZFPL1
Zinc finger protein-like 1

2

0

High-throughput

0.580

High

1203127

SGMR2
Sigma intracellular receptor 2

2

0

High-throughput

0.580

High

1328187

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.580

High

1350308

AGR3
Anterior gradient protein 3

2

0

High-throughput

0.580

High

1352354

RHBL4
Rhomboid-related protein 4

2

0

High-throughput

0.580

High

1386923

F241B
Protein FAM241B

2

0

High-throughput

0.580

High

1388794

YIPF6
Protein YIPF6

2

0

High-throughput

0.580

High

1406329

MARH5
E3 ubiquitin-protein ligase MARCHF5

2

0

High-throughput

0.580

High

1406333

LCAP
Leucyl-cystinyl aminopeptidase

2

0

High-throughput

0.580

High

230406

CREB3
Cyclic AMP-responsive element-binding protein 3

2

0

High-throughput

0.565

High

641475

CD72
B-cell differentiation antigen CD72

2

1

High-throughput

0.553

High

688617

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

2

1

High-throughput

0.553

High

1406316

ZNT3
Probable proton-coupled zinc antiporter SLC30A3

2

1

High-throughput

0.553

High

1406319

ULBP2
UL16-binding protein 2

1

1

High-throughput

0.536

High

253565

PEX10
Peroxisome biogenesis factor 10

1

0

High-throughput

0.518

High

166990

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.513

High

484211

PGFRB
Platelet-derived growth factor receptor beta

1

0

High-throughput

0.513

High

762358

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.513

High

791655

SYUA
Alpha-synuclein

1

0

High-throughput

0.513

High

1085371

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

0

High-throughput

0.513

High

1180955

HFE
Hereditary hemochromatosis protein

1

0

High-throughput

0.513

High

1381231

WBP2
WW domain-binding protein 2

1

0

High-throughput

0.513

High

1392284

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.513

High

188975

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.479

High

565692

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

1

High-throughput

0.479

High

124644

EYA2
Protein phosphatase EYA2

1

0

High-throughput

0.458

High

144475

SCD
Stearoyl-CoA desaturase

1

0

High-throughput

0.458

High

158299

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

338940

CBX6
Chromobox protein homolog 6

1

0

High-throughput

0.458

High

834225

CSK
Tyrosine-protein kinase CSK

1

0

High-throughput

0.458

High

908046

VAMP7
Vesicle-associated membrane protein 7

1

0

High-throughput

0.458

High

1164007

HCDH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

1214901

WLS
Protein wntless homolog

1

0

High-throughput

0.458

High

1390329

ZN503
Zinc finger protein 503

1

0

High-throughput

0.458

High

1392783

P121A
Nuclear envelope pore membrane protein POM 121

1

0

High-throughput

0.458

High

1406315

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

High-throughput

0.458

High

1406328

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

High-throughput

0.458

High

1406325

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.437

High

1359490

CTL1
Choline transporter-like protein 1

1

0

High-throughput

0.426

High

1207962

COL12
Collectin-12

3

0

High-throughput

0.347

High

1368822

N42L2
NEDD4-binding protein 2-like 2

3

0

High-throughput

0.347

High

1386457

PKHB2
Pleckstrin homology domain-containing family B member 2

3

0

High-throughput

0.347

High

1406334

KDIS
Kinase D-interacting substrate of 220 kDa

3

0

High-throughput

0.347

High

251111

B4GT3
Beta-1,4-galactosyltransferase 3

2

0

High-throughput

0.328

High

931434

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

2

0

High-throughput

0.328

High

1237885

MYORG
Myogenesis-regulating glycosidase

2

0

High-throughput

0.328

High

1406337

PCDC2
Protocadherin alpha-C2

2

0

High-throughput

0.328

High

1164157

CP51A
Lanosterol 14-alpha demethylase

2

0

High-throughput

0.318

High

1209995

TM201
Transmembrane protein 201

2

0

High-throughput

0.318

High

1307969

EPHX4
Epoxide hydrolase 4

2

0

High-throughput

0.318

High

162267

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

2

0

High-throughput

0.316

High

194739

FFAR2
Free fatty acid receptor 2

2

0

High-throughput

0.316

High

1129223

TM187
Transmembrane protein 187

2

0

High-throughput

0.316

High

1256657

TPRG1
Tumor protein p63-regulated gene 1 protein

2

0

High-throughput

0.316

High

1290524

LAP4B
Lysosomal-associated transmembrane protein 4B

2

0

High-throughput

0.316

High

1351688

GP152
Probable G-protein coupled receptor 152

2

0

High-throughput

0.316

High

1351760

GP151
G-protein coupled receptor 151

2

0

High-throughput

0.316

High

1379844

SCAM4
Secretory carrier-associated membrane protein 4

2

0

High-throughput

0.316

High

1394422

FXDC2
Fatty acid hydroxylase domain-containing protein 2

2

0

High-throughput

0.316

High

1396491

SUSD3
Sushi domain-containing protein 3

2

0

High-throughput

0.316

High

1406320

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.316

High

1406326

TM140
Transmembrane protein 140

2

0

High-throughput

0.316

High

1406332

PGAP2
Acyltransferase PGAP2

2

0

High-throughput

0.316

High

248444

NMD3B
Glutamate receptor ionotropic, NMDA 3B

1

0

High-throughput

0.279

Low

424097

ITB2
Integrin beta-2

1

0

High-throughput

0.279

Low

1195456

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.279

Low

1249760

BTNL3
Butyrophilin-like protein 3

1

0

High-throughput

0.279

Low

1386158

FWCH2
FLYWCH family member 2

1

0

High-throughput

0.279

Low

1406321

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

1406322

RXFP1
Relaxin receptor 1

1

0

High-throughput

0.279

Low

1406324

KCMB3
Calcium-activated potassium channel subunit beta-3

1

0

High-throughput

0.279

Low

1406331

DLL3
Delta-like protein 3

1

0

High-throughput

0.279

Low

1207759

TMM31
Transmembrane protein 31

1

0

High-throughput

0.251

Low

275727

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.249

Low

363763

EGFR
Epidermal growth factor receptor

1

0

Small-scale

0.249

Low

592886

CBR1
Carbonyl reductase [NADPH] 1

1

0

High-throughput

0.249

Low

1158697

DPYL2
Dihydropyrimidinase-related protein 2

1

0

High-throughput

0.249

Low

1217111

EMC10
ER membrane protein complex subunit 10

1

0

High-throughput

0.249

Low

1334254

ATAD1
Outer mitochondrial transmembrane helix translocase

1

0

High-throughput

0.249

Low

1370012

GSLG1
Golgi apparatus protein 1

1

0

High-throughput

0.249

Low

1406317

TM9S2
Transmembrane 9 superfamily member 2

1

0

High-throughput

0.249

Low

1406323

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

0

High-throughput

0.249

Low

1406335

DJC16
DnaJ homolog subfamily C member 16

1

0

High-throughput

0.249

Low

1406336

TMX2
Thioredoxin-related transmembrane protein 2

1

0

High-throughput

0.249

Low

1316355

AGRG5
Adhesion G-protein coupled receptor G5

1

0

High-throughput

0.232

Low

1335427

SPX3
Sugar phosphate exchanger 3

1

0

High-throughput

0.232

Low

1406318

S12A9
Solute carrier family 12 member 9

1

0

High-throughput

0.232

Low

1406330

SO1C1
Solute carrier organic anion transporter family member 1C1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025