Protein: EMC8
ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B)

Gene: EMC8
Organism: Homo sapiens
Interactions: 238
UniProt ID: O43402

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

215563

EMC2
ER membrane protein complex subunit 2

21

5

Small-scale

0.989

High

215600

EMC5
ER membrane protein complex subunit 5

5

1

High-throughput

0.932

High

215656

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

5

2

High-throughput

0.720

High

215672

EMC3
ER membrane protein complex subunit 3

5

2

High-throughput

0.714

High

215603

EMC1
ER membrane protein complex subunit 1

4

2

High-throughput

0.699

High

215578

EMC4
ER membrane protein complex subunit 4

3

2

High-throughput

0.675

High

215523

VMAT1
Chromaffin granule amine transporter

3

0

High-throughput

0.638

High

215554

TRDN
Triadin

2

1

High-throughput

0.628

High

215618

LPAR1
Lysophosphatidic acid receptor 1

2

1

High-throughput

0.628

High

215644

EMC6
ER membrane protein complex subunit 6

2

1

High-throughput

0.628

High

215527

SC61B
Protein transport protein Sec61 subunit beta

3

0

High-throughput

0.628

High

215502

CALX
Calnexin

2

1

High-throughput

0.611

High

215680

FBX2
F-box only protein 2

2

1

High-throughput

0.601

High

215483

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

0

High-throughput

0.585

High

215484

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

2

0

High-throughput

0.585

High

215634

KCNKG
Potassium channel subfamily K member 16

2

0

High-throughput

0.585

High

215605

RN149
E3 ubiquitin-protein ligase RNF149

2

3

Small-scale

0.584

High

48450

ESYT2
Extended synaptotagmin-2

2

2

High-throughput

0.571

High

215604

DHB11
Estradiol 17-beta-dehydrogenase 11

2

2

High-throughput

0.571

High

215519

BAP31
B-cell receptor-associated protein 31

2

0

High-throughput

0.547

High

215549

REEP5
Receptor expression-enhancing protein 5

2

0

High-throughput

0.547

High

215646

LNP
Endoplasmic reticulum junction formation protein lunapark

2

0

High-throughput

0.547

High

210806

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.536

High

215469

MTA2
Metastasis-associated protein MTA2

1

1

High-throughput

0.536

High

215474

S1PR4
Sphingosine 1-phosphate receptor 4

1

1

High-throughput

0.536

High

215493

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.536

High

215496

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

High-throughput

0.536

High

215499

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.536

High

215500

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.536

High

215507

MATR3
Matrin-3

1

1

High-throughput

0.536

High

215509

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.536

High

215510

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.536

High

215514

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.536

High

215521

COPA
Coatomer subunit alpha

1

1

High-throughput

0.536

High

215522

SYRC
Arginine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.536

High

215525

SYMC
Methionine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.536

High

215532

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.536

High

215533

RS8
Small ribosomal subunit protein eS8

1

1

High-throughput

0.536

High

215534

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

215535

RS23
Small ribosomal subunit protein uS12

1

1

High-throughput

0.536

High

215536

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.536

High

215537

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.536

High

215538

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.536

High

215539

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.536

High

215540

RL32
Large ribosomal subunit protein eL32

1

1

High-throughput

0.536

High

215541

RL11
Large ribosomal subunit protein uL5

1

2

High-throughput

0.536

High

215543

RL38
Large ribosomal subunit protein eL38

1

1

High-throughput

0.536

High

215546

RL24
Large ribosomal subunit protein eL24

1

1

High-throughput

0.536

High

215551

DHX9
ATP-dependent RNA helicase A

1

1

High-throughput

0.536

High

215553

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

1

High-throughput

0.536

High

215556

PABP4
Polyadenylate-binding protein 4

1

2

High-throughput

0.536

High

215559

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

2

High-throughput

0.536

High

215566

SYK
Lysine--tRNA ligase

1

3

High-throughput

0.536

High

215580

EMC10
ER membrane protein complex subunit 10

1

2

High-throughput

0.536

High

215590

KTN1
Kinectin

1

2

High-throughput

0.536

High

215623

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

215637

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.536

High

215661

FBX6
F-box only protein 6

1

1

High-throughput

0.536

High

215673

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

215679

UBQL2
Ubiquilin-2

1

1

High-throughput

0.536

High

215684

PRC2C
Protein PRRC2C

1

1

High-throughput

0.536

High

215577

KLH22
Kelch-like protein 22

2

0

High-throughput

0.528

High

129923

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.513

High

158057

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

215463

S28A2
Sodium/nucleoside cotransporter 2

1

0

High-throughput

0.513

High

215479

K2C6A
Keratin, type II cytoskeletal 6A

1

0

High-throughput

0.513

High

215488

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.513

High

215504

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.513

High

215515

PSN1
Presenilin-1

1

0

High-throughput

0.513

High

215579

WDR44
WD repeat-containing protein 44

1

0

High-throughput

0.513

High

215593

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

215598

D106A
Beta-defensin 106

1

0

High-throughput

0.513

High

215602

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.513

High

215612

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.513

High

215640

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

215662

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

0

High-throughput

0.513

High

215665

PARVA
Alpha-parvin

1

0

High-throughput

0.513

High

215524

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

1

High-throughput

0.489

High

215620

STAM1
Signal transducing adapter molecule 1

1

2

High-throughput

0.489

High

215485

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

173782

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

215462

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

215487

RHOC
Rho-related GTP-binding protein RhoC

1

5

High-throughput

0.479

High

215495

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

215505

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.479

High

215528

RAC3
Ras-related C3 botulinum toxin substrate 3

1

5

High-throughput

0.479

High

215529

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.479

High

215530

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

215548

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

215550

CKAP4
Cytoskeleton-associated protein 4

1

1

High-throughput

0.479

High

215570

T22D1
TSC22 domain family protein 1

1

1

High-throughput

0.479

High

215573

TECT1
Tectonic-1

1

2

High-throughput

0.479

High

215589

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

3

High-throughput

0.479

High

215592

GOLI
E3 ubiquitin-protein ligase RNF130

1

3

High-throughput

0.479

High

215594

MIRO2
Mitochondrial Rho GTPase 2

1

7

High-throughput

0.479

High

215627

TECT2
Tectonic-2

1

2

High-throughput

0.479

High

215628

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

215632

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

1

High-throughput

0.479

High

215649

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.479

High

215650

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.479

High

215660

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.479

High

215664

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.479

High

215681

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.479

High

215464

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.458

High

215476

RASK
GTPase KRas

1

0

High-throughput

0.458

High

215494

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

215498

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

215508

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

215516

EMD
Emerin

1

0

High-throughput

0.458

High

215517

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

215526

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

215544

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

215552

STX4
Syntaxin-4

1

0

High-throughput

0.458

High

215557

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

215558

CUL3
Cullin-3

1

0

High-throughput

0.458

High

215560

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

215586

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

215595

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

215624

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

215630

TM237
Transmembrane protein 237

1

0

High-throughput

0.458

High

215631

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

215635

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

215636

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

215643

DERL1
Derlin-1

1

0

High-throughput

0.458

High

215654

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

215659

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

215670

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

215674

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

215676

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

215678

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.458

High

104306

F5H6I7
Atlastin GTPase 3

1

2

High-throughput

0.445

High

166221

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

1

High-throughput

0.445

High

215465

RTN2
Reticulon-2

1

2

High-throughput

0.445

High

215467

STAM2
Signal transducing adapter molecule 2

1

2

High-throughput

0.445

High

215472

RTN3
Reticulon-3

1

2

High-throughput

0.445

High

215473

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.445

High

215486

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

1

High-throughput

0.445

High

215490

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

215501

CALR
Calreticulin

1

1

High-throughput

0.445

High

215503

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.445

High

215568

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.445

High

215571

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

1

High-throughput

0.445

High

215576

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.445

High

215581

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.445

High

215597

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

1

High-throughput

0.445

High

215609

ATLA2
Atlastin-2

1

2

High-throughput

0.445

High

215611

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

1

High-throughput

0.445

High

215616

ATLA1
Atlastin-1

1

2

High-throughput

0.445

High

215622

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.445

High

215629

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.445

High

215641

ESYT1
Extended synaptotagmin-1

1

2

High-throughput

0.445

High

215652

TMX1
Thioredoxin-related transmembrane protein 1

1

1

High-throughput

0.445

High

215657

RTN4
Reticulon-4

1

2

High-throughput

0.445

High

215677

COPG2
Coatomer subunit gamma-2

1

1

High-throughput

0.445

High

215682

DHRS7
Dehydrogenase/reductase SDR family member 7

1

1

High-throughput

0.445

High

215683

TMED5
Transmembrane emp24 domain-containing protein 5

1

2

High-throughput

0.445

High

215687

COPG1
Coatomer subunit gamma-1

1

1

High-throughput

0.445

High

126382

RHOD
Rho-related GTP-binding protein RhoD

1

6

High-throughput

0.437

High

215480

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.437

High

215582

TECT3
Tectonic-3

1

2

High-throughput

0.437

High

215617

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.437

High

215668

CLC5A
C-type lectin domain family 5 member A

1

2

High-throughput

0.437

High

50448

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.426

High

60269

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.426

High

211692

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.426

High

215466

ERLN1
Erlin-1

1

0

High-throughput

0.426

High

215471

MICA2
[F-actin]-monooxygenase MICAL2

1

0

High-throughput

0.426

High

215475

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.426

High

215491

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

215492

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.426

High

215506

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.426

High

215511

COPD
Coatomer subunit delta

1

0

High-throughput

0.426

High

215512

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.426

High

215518

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.426

High

215520

COPB
Coatomer subunit beta

1

0

High-throughput

0.426

High

215531

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.426

High

215542

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.426

High

215545

NUCB2
Nucleobindin-2

1

0

High-throughput

0.426

High

215547

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.426

High

215555

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.426

High

215561

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.426

High

215562

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.426

High

215564

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.426

High

215565

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

215567

RCN1
Reticulocalbin-1

1

0

High-throughput

0.426

High

215569

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.426

High

215574

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.426

High

215583

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.426

High

215584

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.426

High

215601

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.426

High

215606

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.426

High

215610

MCFD2
Multiple coagulation factor deficiency protein 2

1

0

High-throughput

0.426

High

215614

SCFD1
Sec1 family domain-containing protein 1

1

0

High-throughput

0.426

High

215626

ASTRA
Protein Aster-A

1

0

High-throughput

0.426

High

215638

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.426

High

215639

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.426

High

215642

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.426

High

215645

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.426

High

215651

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

215655

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.426

High

215658

S35C2
Solute carrier family 35 member C2

1

0

High-throughput

0.426

High

215663

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.426

High

215666

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.426

High

215671

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

215686

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.426

High

215575

BCL7A
B-cell CLL/lymphoma 7 protein family member A

2

0

High-throughput

0.328

High

215468

RAD17
Cell cycle checkpoint protein RAD17

1

0

High-throughput

0.279

Low

215470

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.279

Low

215477

GON1
Progonadoliberin-1

1

0

High-throughput

0.279

Low

215478

IFN21
Interferon alpha-21

1

0

High-throughput

0.279

Low

215481

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.279

Low

215482

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.279

Low

215489

SAA1
Serum amyloid A-1 protein

1

0

High-throughput

0.279

Low

215497

EGLN
Endoglin

1

0

High-throughput

0.279

Low

215572

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.279

Low

215588

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.279

Low

215596

F186B
Protein FAM186B

1

0

High-throughput

0.279

Low

215608

OR4N2
Olfactory receptor 4N2

1

0

High-throughput

0.279

Low

215621

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.279

Low

215653

SPRNG
SREBP regulating gene protein

1

0

High-throughput

0.279

Low

215675

ZN581
Zinc finger protein 581

1

0

High-throughput

0.279

Low

215685

OR1A2
Olfactory receptor 1A2

1

0

High-throughput

0.279

Low

215585

ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6

1

0

High-throughput

0.249

Low

215591

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

215599

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

215615

5HT3C
5-hydroxytryptamine receptor 3C

1

0

High-throughput

0.249

Low

215619

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

215625

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.249

Low

215647

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.249

Low

213540

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.232

Low

215513

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

High-throughput

0.232

Low

215587

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

High-throughput

0.232

Low

215607

VP37A
Vacuolar protein sorting-associated protein 37A

1

0

High-throughput

0.232

Low

215613

S22AH
Solute carrier family 22 member 17

1

0

High-throughput

0.232

Low

215633

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low

215648

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.232

Low

215667

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.232

Low

215669

PSD3
PH and SEC7 domain-containing protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025