Protein: SMO
Protein smoothened (Protein Gx)

Gene: SMO
Organism: Homo sapiens
Interactions: 47
UniProt ID: Q99835

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001570 - vasculogenesis
GO:0001649 - osteoblast differentiation
GO:0001701 - in utero embryonic development
GO:0001708 - cell fate specification

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1116283

PTC1
Protein patched homolog 1

2

4

Small-scale

0.615

High

1104471

ILK
Scaffold protein ILK

1

0

Small-scale

0.586

High

989868

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

2

Small-scale

0.575

High

861747

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

Small-scale

0.552

High

270115

TMCC2
Transmembrane and coiled-coil domains protein 2

1

1

High-throughput

0.541

High

483956

HMOX1
Heme oxygenase 1

1

1

High-throughput

0.541

High

720025

HMOX2
Heme oxygenase 2

1

1

High-throughput

0.541

High

835583

TSN7
Tetraspanin-7

1

4

High-throughput

0.541

High

1125624

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

1

High-throughput

0.541

High

1360732

JPH3
Junctophilin-3

1

1

High-throughput

0.541

High

1392580

S41A3
Solute carrier family 41 member 3

1

1

High-throughput

0.541

High

170933

CLGN
Calmegin

1

3

High-throughput

0.536

High

248501

O10H2
Olfactory receptor 10H2

1

4

High-throughput

0.536

High

771811

SCN4A
Sodium channel protein type 4 subunit alpha

1

4

High-throughput

0.536

High

851201

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

3

High-throughput

0.536

High

1203781

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

1407659

TTYH1
Protein tweety homolog 1

1

2

High-throughput

0.536

High

161573

ITBP1
Integrin beta-1-binding protein 1

1

0

High-throughput

0.518

High

183884

OBRG
Leptin receptor gene-related protein

1

0

High-throughput

0.518

High

418386

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.518

High

952309

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

High-throughput

0.518

High

1131499

SSPN
Sarcospan

1

0

High-throughput

0.518

High

1214902

WLS
Protein wntless homolog

1

0

High-throughput

0.518

High

1273795

NIPA1
Magnesium transporter NIPA1

1

0

High-throughput

0.518

High

1349600

CR032
UPF0729 protein C18orf32

1

0

High-throughput

0.518

High

1407656

NFIP1
NEDD4 family-interacting protein 1

1

0

High-throughput

0.518

High

1407657

S1PR5
Sphingosine 1-phosphate receptor 5

1

0

High-throughput

0.518

High

1407658

ARV1
Protein ARV1

1

0

High-throughput

0.518

High

1407661

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

0

High-throughput

0.518

High

832786

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.513

High

1328551

NGEF
Ephexin-1

1

1

High-throughput

0.494

High

1010522

EREP3
Protein ENTREP3

1

1

High-throughput

0.489

High

669145

ARBK1
Beta-adrenergic receptor kinase 1

1

2

Small-scale

0.479

High

732684

ARRB2
Beta-arrestin-2

1

4

Small-scale

0.479

High

882555

ARRB1
Beta-arrestin-1

1

4

Small-scale

0.479

High

1407662

PTC2
Protein patched homolog 2

1

4

Small-scale

0.479

High

189800

STX7
Syntaxin-7

1

0

High-throughput

0.458

High

976516

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

983564

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

2

Small-scale

0.445

High

1390781

S47A1
Multidrug and toxin extrusion protein 1

1

2

High-throughput

0.445

High

1204541

HERC4
Probable E3 ubiquitin-protein ligase HERC4

1

3

Small-scale

0.437

High

137473

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

0

High-throughput

0.282

High

1217112

EMC10
ER membrane protein complex subunit 10

1

0

High-throughput

0.282

High

1334273

PLPP7
Inactive phospholipid phosphatase 7

1

0

High-throughput

0.282

High

1358706

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

1

0

High-throughput

0.282

High

1407660

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.282

High

992419

GBG1
Guanine nucleotide-binding protein G(T) subunit gamma-T1

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025