Protein: EMC3
ER membrane protein complex subunit 3 (Transmembrane protein 111)

Gene: EMC3
Organism: Homo sapiens
Interactions: 131
UniProt ID: Q9P0I2

Gene Ontology (top 5):
GO:0005789 - endoplasmic reticulum membrane
GO:0016020 - membrane
GO:0045050 - protein insertion into ER membrane by stop-transfer membrane-anchor sequence
GO:0071816 - tail-anchored membrane protein insertion into ER membrane
GO:0072546 - EMC complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1136397

EMC2
ER membrane protein complex subunit 2

9

2

Small-scale

0.972

High

1205497

EMC4
ER membrane protein complex subunit 4

6

2

High-throughput

0.949

High

1330422

EMC1
ER membrane protein complex subunit 1

6

2

High-throughput

0.949

High

1415013

EMC6
ER membrane protein complex subunit 6

3

0

High-throughput

0.787

High

1217123

EMC10
ER membrane protein complex subunit 10

5

1

High-throughput

0.720

High

1446114

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

5

1

High-throughput

0.720

High

1453748

EMC9
ER membrane protein complex subunit 9

5

2

High-throughput

0.720

High

1326931

EMC5
ER membrane protein complex subunit 5

7

0

High-throughput

0.717

High

215672

EMC8
ER membrane protein complex subunit 8

5

2

High-throughput

0.714

High

1453745

TMCO1
Calcium load-activated calcium channel

1

0

High-throughput

0.656

High

1093595

TRDN
Triadin

2

0

High-throughput

0.602

High

699209

CALX
Calnexin

2

0

High-throughput

0.585

High

1334602

RN149
E3 ubiquitin-protein ligase RNF149

2

0

Small-scale

0.559

High

1453743

FBX2
F-box only protein 2

2

1

High-throughput

0.549

High

230210

S28A2
Sodium/nucleoside cotransporter 2

1

1

High-throughput

0.536

High

813243

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.536

High

926859

VMAT1
Chromaffin granule amine transporter

1

1

High-throughput

0.536

High

1448291

FBX6
F-box only protein 6

2

1

High-throughput

0.521

High

142160

NPT3
Sodium-dependent phosphate transport protein 3

1

0

High-throughput

0.513

High

158340

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

417815

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.513

High

944343

TMM33
Transmembrane protein 33

1

0

High-throughput

0.513

High

951481

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.513

High

1180870

S4A8
Electroneutral sodium bicarbonate exchanger 1

1

0

High-throughput

0.513

High

1322531

D106A
Beta-defensin 106

1

0

High-throughput

0.513

High

1329322

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.513

High

1333714

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.513

High

1382226

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1428313

DERL2
Derlin-2

1

0

High-throughput

0.513

High

1453739

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.513

High

48829

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

466501

RHOC
Rho-related GTP-binding protein RhoC

1

6

High-throughput

0.479

High

581339

RAC2
Ras-related C3 botulinum toxin substrate 2

1

6

High-throughput

0.479

High

953719

RAC3
Ras-related C3 botulinum toxin substrate 3

1

6

High-throughput

0.479

High

955692

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.479

High

962572

RHOA
Transforming protein RhoA

1

7

High-throughput

0.479

High

988773

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.479

High

1015863

RHOG
Rho-related GTP-binding protein RhoG

1

6

High-throughput

0.479

High

1179154

TECT1
Tectonic-1

1

2

High-throughput

0.479

High

1312292

MIRO2
Mitochondrial Rho GTPase 2

1

9

High-throughput

0.479

High

1395971

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

1412704

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

1431273

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.479

High

1448841

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.479

High

1453741

SEC63
Translocation protein SEC63 homolog

1

1

High-throughput

0.479

High

1453744

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

1453747

DJC16
DnaJ homolog subfamily C member 16

1

1

High-throughput

0.479

High

290180

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

337977

CNEP1
CTD nuclear envelope phosphatase 1

1

0

High-throughput

0.458

High

363947

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

508743

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

939981

TPTE
Putative tyrosine-protein phosphatase TPTE

1

0

High-throughput

0.458

High

1114500

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1123845

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

1125709

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1138705

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1204906

MKS3
Meckelin

1

0

High-throughput

0.458

High

1249277

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1309907

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1327002

DJC22
DnaJ homolog subfamily C member 22

1

0

High-throughput

0.458

High

1337701

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.458

High

1351997

RBCC1
RB1-inducible coiled-coil protein 1

1

0

High-throughput

0.458

High

1400566

TM237
Transmembrane protein 237

1

0

High-throughput

0.458

High

1420147

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

0

Small-scale

0.458

High

1439367

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.458

High

1448160

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

1453740

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1453749

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

126842

RHOD
Rho-related GTP-binding protein RhoD

1

8

High-throughput

0.437

High

189015

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.437

High

910231

RND2
Rho-related GTP-binding protein RhoN

1

8

High-throughput

0.437

High

1151908

RHOH
Rho-related GTP-binding protein RhoH

1

7

High-throughput

0.437

High

1238843

TECT3
Tectonic-3

1

2

High-throughput

0.437

High

1286939

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

1360953

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

1392489

TECT2
Tectonic-2

1

2

High-throughput

0.437

High

1438203

RHOF
Rho-related GTP-binding protein RhoF

1

8

High-throughput

0.437

High

933491

S12A2
Solute carrier family 12 member 2

1

0

High-throughput

0.426

High

1131638

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.426

High

1180333

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.426

High

1236362

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

1335756

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.426

High

1365137

SL9A6
Sodium/hydrogen exchanger 6

1

0

High-throughput

0.426

High

132928

S28A1
Sodium/nucleoside cotransporter 1

1

1

High-throughput

0.407

High

351737

SG1D1
Secretoglobin family 1D member 1

2

0

High-throughput

0.328

High

378300

IFN21
Interferon alpha-21

2

0

High-throughput

0.328

High

566858

PDIA4
Protein disulfide-isomerase A4

2

0

High-throughput

0.328

High

1248848

ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6

2

0

High-throughput

0.318

High

1095231

MTAP
S-methyl-5'-thioadenosine phosphorylase

2

0

High-throughput

0.316

High

1199725

KLH22
Kelch-like protein 22

2

0

High-throughput

0.288

High

326491

NDUB6
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

1

0

High-throughput

0.279

Low

376960

GON1
Progonadoliberin-1

1

0

High-throughput

0.279

Low

387572

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.279

Low

515909

SAA1
Serum amyloid A-1 protein

1

0

High-throughput

0.279

Low

771825

SCN4A
Sodium channel protein type 4 subunit alpha

1

0

High-throughput

0.279

Low

932955

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.279

Low

1142201

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.279

Low

1155047

ADIPO
Adiponectin

1

0

High-throughput

0.279

Low

1206610

PLAC9
Placenta-specific protein 9

1

0

High-throughput

0.279

Low

1325174

TAFA2
Chemokine-like protein TAFA-2

1

0

High-throughput

0.279

Low

1396519

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.279

Low

1417577

MAK16
Protein MAK16 homolog

1

0

High-throughput

0.279

Low

1453742

UBQL2
Ubiquilin-2

1

0

High-throughput

0.279

Low

218886

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

227695

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

589902

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

611393

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.249

Low

696720

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

769378

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

901629

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.249

Low

971210

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1005188

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1122573

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.249

Low

1162600

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

1228482

FTM
Protein fantom

1

0

High-throughput

0.249

Low

1255875

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1276891

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1293182

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1382966

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1397504

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1403816

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.249

Low

1430609

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.249

Low

1434096

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1450117

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1453746

AT1B4
Protein ATP1B4

1

0

High-throughput

0.249

Low

1126010

LRC32
Transforming growth factor beta activator LRRC32

1

0

High-throughput

0.232

Low

1356679

S22AH
Solute carrier family 22 member 17

1

0

High-throughput

0.232

Low

1366280

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low

1387803

MUCL1
Mucin-like protein 1

1

0

High-throughput

0.232

Low

1389483

NTCP4
Sodium/bile acid cotransporter 4

1

0

High-throughput

0.232

Low

1447168

S35C2
Solute carrier family 35 member C2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025