Protein: AT131
Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase)

Gene: AT131, ATP13A1
Organism: Homo sapiens
Interactions: 214
UniProt ID: Q9HD20

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005789 - endoplasmic reticulum membrane
GO:0006874 - intracellular calcium ion homeostasis
GO:0015031 - protein transport
GO:0015410 - ABC-type manganese transporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1010107

DLK1
Protein delta homolog 1

4

5

High-throughput

0.691

High

1439530

SCN3B
Sodium channel regulatory subunit beta-3

3

6

High-throughput

0.665

High

174104

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

15

High-throughput

0.618

High

668232

CXCR2
C-X-C chemokine receptor type 2

2

20

High-throughput

0.606

High

934287

BI1
Bax inhibitor 1

2

2

High-throughput

0.606

High

1186048

SOAT
Sodium-dependent organic anion transporter

2

2

High-throughput

0.606

High

1210311

MF14B
Hippocampus abundant transcript-like protein 1

2

3

High-throughput

0.606

High

1219243

SYPL2
Synaptophysin-like protein 2

2

2

High-throughput

0.606

High

1292377

UN93A
Protein unc-93 homolog A

2

4

High-throughput

0.606

High

1398484

TLCD4
TLC domain-containing protein 4

2

1

High-throughput

0.606

High

1411148

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

6

High-throughput

0.606

High

1428510

ELOV4
Very long chain fatty acid elongase 4

2

6

High-throughput

0.606

High

1288336

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

3

12

High-throughput

0.604

High

1213710

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

2

3

High-throughput

0.601

High

1239051

NIPA3
Magnesium transporter NIPA3

2

7

High-throughput

0.601

High

1439538

VSIG4
V-set and immunoglobulin domain-containing protein 4

2

6

High-throughput

0.601

High

1439523

S35C2
Solute carrier family 35 member C2

3

3

High-throughput

0.591

High

951446

SC61B
Protein transport protein Sec61 subunit beta

2

4

High-throughput

0.584

High

1142948

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.580

High

1149883

PAQRB
Monocyte to macrophage differentiation factor

2

0

High-throughput

0.580

High

1191801

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

2

0

High-throughput

0.580

High

1242816

RNK
Ribonuclease kappa

2

0

High-throughput

0.580

High

1400553

TM237
Transmembrane protein 237

2

0

High-throughput

0.580

High

1439522

MANBL
Protein MANBAL

2

0

High-throughput

0.580

High

396995

ESR1
Estrogen receptor

2

9

High-throughput

0.571

High

988730

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

High-throughput

0.571

High

194752

FFAR2
Free fatty acid receptor 2

2

20

High-throughput

0.553

High

1109052

AQP6
Aquaporin-6

2

1

High-throughput

0.553

High

1274092

MOT13
Monocarboxylate transporter 13

2

10

High-throughput

0.553

High

1310953

ZNT8
Proton-coupled zinc antiporter SLC30A8

2

6

High-throughput

0.553

High

1316162

KMT2E
Inactive histone-lysine N-methyltransferase 2E

2

5

High-throughput

0.553

High

846098

GLP1R
Glucagon-like peptide 1 receptor

1

10

Small-scale

0.552

High

1153441

CD226
CD226 antigen

2

8

High-throughput

0.549

High

1390887

ASIC4
Acid-sensing ion channel 4

2

1

High-throughput

0.549

High

1399619

OPALI
Opalin

2

3

High-throughput

0.549

High

1435993

PACC1
Proton-activated chloride channel

2

2

High-throughput

0.549

High

720700

AGTR1
Type-1 angiotensin II receptor

1

20

High-throughput

0.541

High

130251

PGRC1
Membrane-associated progesterone receptor component 1

1

5

High-throughput

0.536

High

181440

PGRC2
Membrane-associated progesterone receptor component 2

1

5

High-throughput

0.536

High

226371

SNG1
Synaptogyrin-1

1

2

High-throughput

0.536

High

231014

TYOBP
TYRO protein tyrosine kinase-binding protein

1

3

High-throughput

0.536

High

376646

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

1

High-throughput

0.536

High

669288

PTAFR
Platelet-activating factor receptor

1

20

High-throughput

0.536

High

683342

TNR5
Tumor necrosis factor receptor superfamily member 5

1

14

High-throughput

0.536

High

699153

CALX
Calnexin

1

7

High-throughput

0.536

High

719747

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

5

High-throughput

0.536

High

749810

CADH5
Cadherin-5

1

7

High-throughput

0.536

High

878098

AGRE5
Adhesion G protein-coupled receptor E5

1

5

High-throughput

0.536

High

1098145

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

High-throughput

0.536

High

1126368

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

3

High-throughput

0.536

High

1187420

SHSL1
Protein shisa-like-1

1

1

High-throughput

0.536

High

1292025

TPRA1
Transmembrane protein adipocyte-associated 1

1

2

High-throughput

0.536

High

1324865

LRC25
Leucine-rich repeat-containing protein 25

1

1

High-throughput

0.536

High

1331198

F241A
Uncharacterized protein FAM241A

1

1

High-throughput

0.536

High

1382205

CCD47
PAT complex subunit CCDC47

1

3

High-throughput

0.536

High

1406547

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

3

High-throughput

0.536

High

1431624

CXL16
C-X-C motif chemokine 16

1

2

High-throughput

0.536

High

1439529

EVA1B
Protein eva-1 homolog B

1

3

High-throughput

0.536

High

1439545

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

7

High-throughput

0.536

High

1134169

NTCP
Hepatic sodium/bile acid cotransporter

2

2

High-throughput

0.526

High

1029947

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.518

High

1357798

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.513

High

1439535

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.513

High

69617

CLM7
CMRF35-like molecule 7

1

7

High-throughput

0.489

High

71403

HECA2
HEPACAM family member 2

1

3

High-throughput

0.489

High

218805

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.489

High

253906

TPST2
Protein-tyrosine sulfotransferase 2

1

4

High-throughput

0.489

High

349580

TSN15
Tetraspanin-15

1

16

High-throughput

0.489

High

615163

GBRG2
Gamma-aminobutyric acid receptor subunit gamma-2

1

3

High-throughput

0.489

High

689860

CD27
CD27 antigen

1

13

High-throughput

0.489

High

699578

IL1R2
Interleukin-1 receptor type 2

1

1

High-throughput

0.489

High

907061

CCR6
C-C chemokine receptor type 6

1

20

High-throughput

0.489

High

935386

IOD3
Thyroxine 5-deiodinase

1

1

High-throughput

0.489

High

1029632

CD83
CD83 antigen

1

1

High-throughput

0.489

High

1057701

TNR9
Tumor necrosis factor receptor superfamily member 9

1

13

High-throughput

0.489

High

1203800

TTMP
TPA-induced transmembrane protein

1

3

High-throughput

0.489

High

1249512

VSTM1
V-set and transmembrane domain-containing protein 1

1

3

High-throughput

0.489

High

1270287

BT2A1
Butyrophilin subfamily 2 member A1

1

8

High-throughput

0.489

High

1325161

TM130
Transmembrane protein 130

1

1

High-throughput

0.489

High

1348641

S7A14
Solute carrier family 7 member 14

1

4

High-throughput

0.489

High

1351742

GPBAR
G-protein coupled bile acid receptor 1

1

1

High-throughput

0.489

High

1394654

TXD15
Thioredoxin domain-containing protein 15

1

2

High-throughput

0.489

High

1420323

CD244
Natural killer cell receptor 2B4

1

9

High-throughput

0.489

High

1431373

TSN10
Tetraspanin-10

1

16

High-throughput

0.489

High

1438457

LPAR2
Lysophosphatidic acid receptor 2

1

20

High-throughput

0.489

High

1439543

PCDGL
Protocadherin gamma-C4

1

16

High-throughput

0.489

High

360123

NB5R3
NADH-cytochrome b5 reductase 3

1

7

High-throughput

0.481

High

1439539

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

3

High-throughput

0.481

High

258339

TRI13
E3 ubiquitin-protein ligase TRIM13

1

6

High-throughput

0.479

High

291551

NU155
Nuclear pore complex protein Nup155

1

3

High-throughput

0.479

High

401524

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

412646

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.479

High

417773

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

4

High-throughput

0.479

High

418448

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

3

High-throughput

0.479

High

487779

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

540690

LAMP1
Lysosome-associated membrane glycoprotein 1

1

10

High-throughput

0.479

High

562413

LAMP2
Lysosome-associated membrane glycoprotein 2

1

10

High-throughput

0.479

High

684401

DDX6
Probable ATP-dependent RNA helicase DDX6

1

3

High-throughput

0.479

High

800112

COIL
Coilin

1

2

High-throughput

0.479

High

820754

CEAM6
Cell adhesion molecule CEACAM6

1

1

High-throughput

0.479

High

847704

SSRA
Translocon-associated protein subunit alpha

1

2

High-throughput

0.479

High

895078

EMD
Emerin

1

3

High-throughput

0.479

High

904132

BAP31
B-cell receptor-associated protein 31

1

3

High-throughput

0.479

High

962515

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

975261

ARF6
ADP-ribosylation factor 6

1

6

High-throughput

0.479

High

1136374

EMC2
ER membrane protein complex subunit 2

1

3

High-throughput

0.479

High

1163426

CAH9
Carbonic anhydrase 9

1

4

High-throughput

0.479

High

1211670

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

4

High-throughput

0.479

High

1249230

LMBRL
Protein LMBR1L

1

3

High-throughput

0.479

High

1294265

GOLI
E3 ubiquitin-protein ligase RNF130

1

8

High-throughput

0.479

High

1330403

EMC1
ER membrane protein complex subunit 1

1

3

High-throughput

0.479

High

1334573

RN149
E3 ubiquitin-protein ligase RNF149

1

8

High-throughput

0.479

High

1351983

RBCC1
RB1-inducible coiled-coil protein 1

1

7

High-throughput

0.479

High

1381523

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

3

High-throughput

0.479

High

1401235

PANX1
Pannexin-1

1

1

High-throughput

0.479

High

1404224

SEC62
Translocation protein SEC62

1

5

High-throughput

0.479

High

1414461

DERL1
Derlin-1

1

2

High-throughput

0.479

High

1431255

DJC25
DnaJ homolog subfamily C member 25

1

4

High-throughput

0.479

High

1431755

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

6

High-throughput

0.479

High

1436319

TMT1A
Thiol S-methyltransferase TMT1A

1

2

High-throughput

0.479

High

1439524

PXMP2
Peroxisomal membrane protein 2

1

2

High-throughput

0.479

High

1439531

ELOV5
Very long chain fatty acid elongase 5

1

6

High-throughput

0.479

High

1439534

SEC63
Translocation protein SEC63 homolog

1

7

High-throughput

0.479

High

193452

GPR42
G-protein coupled receptor 42

1

20

High-throughput

0.470

High

791743

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

548374

CP2C9
Cytochrome P450 2C9

1

0

High-throughput

0.458

High

256162

S19A2
Thiamine transporter 1

1

3

High-throughput

0.445

High

351256

MOT3
Monocarboxylate transporter 3

1

10

High-throughput

0.445

High

541060

PIM1
Serine/threonine-protein kinase pim-1

1

3

High-throughput

0.445

High

870422

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

2

High-throughput

0.445

High

946591

EVA1C
Protein eva-1 homolog C

1

3

High-throughput

0.445

High

1048392

ACVR1
Activin receptor type-1

1

4

High-throughput

0.445

High

1068892

NIPA4
Magnesium transporter NIPA4

1

7

High-throughput

0.445

High

1131621

MFS10
Major facilitator superfamily domain-containing protein 10

1

7

High-throughput

0.445

High

1175903

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

2

High-throughput

0.445

High

1209685

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

1224951

S22AA
Solute carrier family 22 member 10

1

8

High-throughput

0.445

High

1236329

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.445

High

1242236

NPAL3
NIPA-like protein 3

1

7

High-throughput

0.445

High

1251715

SPNS3
Protein spinster homolog 3

1

1

High-throughput

0.445

High

1273807

NIPA1
Magnesium transporter NIPA1

1

7

High-throughput

0.445

High

1279086

RIC3
Protein RIC-3

1

2

High-throughput

0.445

High

1313998

S35F3
Solute carrier family 35 member F3

1

1

High-throughput

0.445

High

1326601

CTL3
Choline transporter-like protein 3

1

1

High-throughput

0.445

High

1335431

SPX3
Sugar phosphate exchanger 3

1

4

High-throughput

0.445

High

1335731

MOT11
Monocarboxylate transporter 11

1

11

High-throughput

0.445

High

1348063

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

4

High-throughput

0.445

High

1351533

HAVR2
Hepatitis A virus cellular receptor 2

1

2

High-throughput

0.445

High

1365131

SL9A6
Sodium/hydrogen exchanger 6

1

5

High-throughput

0.445

High

1392716

S39AD
Zinc transporter ZIP13

1

3

High-throughput

0.445

High

1400632

B3A4
Anion exchange protein 4

1

6

High-throughput

0.445

High

1403633

SL9A7
Sodium/hydrogen exchanger 7

1

4

High-throughput

0.445

High

1439532

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

6

High-throughput

0.445

High

1439540

S35A3
UDP-N-acetylglucosamine transporter

1

4

High-throughput

0.445

High

1439542

S27A5
Long-chain fatty acid transport protein 5

1

5

High-throughput

0.445

High

1085523

ARHG5
Rho guanine nucleotide exchange factor 5

1

4

High-throughput

0.439

High

386261

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.437

High

425635

ISG15
Ubiquitin-like protein ISG15

1

7

High-throughput

0.437

High

589755

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

696574

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

715791

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.437

High

769242

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

831467

CCNF
Cyclin-F

1

2

High-throughput

0.437

High

901057

RAB5C
Ras-related protein Rab-5C

1

12

High-throughput

0.437

High

1024859

VIGLN
Vigilin

1

1

High-throughput

0.437

High

1027190

REEP5
Receptor expression-enhancing protein 5

1

2

High-throughput

0.437

High

1107234

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.437

High

1238826

TECT3
Tectonic-3

1

4

High-throughput

0.437

High

1255638

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

1323001

CXD3
Gap junction delta-3 protein

1

8

High-throughput

0.437

High

1334011

DHB11
Estradiol 17-beta-dehydrogenase 11

1

6

High-throughput

0.437

High

1339186

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.437

High

1367339

ESR2
Estrogen receptor beta

1

9

High-throughput

0.437

High

1368389

REQU
Zinc finger protein ubi-d4

1

4

High-throughput

0.437

High

1392472

TECT2
Tectonic-2

1

4

High-throughput

0.437

High

1433952

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

1439528

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

1439533

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.437

High

1439536

LAMP3
Lysosome-associated membrane glycoprotein 3

1

10

High-throughput

0.437

High

337140

NPT2B
Sodium-dependent phosphate transport protein 2B

1

0

High-throughput

0.426

High

1180322

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.426

High

1393211

TM169
Transmembrane protein 169

1

0

High-throughput

0.426

High

1407398

S29A1
Equilibrative nucleoside transporter 1

1

0

High-throughput

0.426

High

628378

CD33
Myeloid cell surface antigen CD33

1

2

High-throughput

0.407

High

653585

HEMH
Ferrochelatase, mitochondrial

1

3

High-throughput

0.407

High

1215261

SL9C2
Sodium/hydrogen exchanger 11

1

6

High-throughput

0.407

High

1246114

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

7

High-throughput

0.407

High

1308982

S22A9
Organic anion transporter 7

1

8

High-throughput

0.407

High

1324181

PLD6
Mitochondrial cardiolipin hydrolase

1

1

High-throughput

0.407

High

1356676

S22AH
Solute carrier family 22 member 17

1

8

High-throughput

0.407

High

1404957

S1PR3
Sphingosine 1-phosphate receptor 3

1

20

High-throughput

0.407

High

1420847

SEM4C
Semaphorin-4C

1

1

High-throughput

0.407

High

1421356

S39A8
Metal cation symporter ZIP8

1

3

High-throughput

0.407

High

1439521

TMM9B
Transmembrane protein 9B

1

6

High-throughput

0.407

High

1439526

CAH10
Carbonic anhydrase-related protein 10

1

4

High-throughput

0.407

High

1439537

S22AE
Solute carrier family 22 member 14

1

8

High-throughput

0.407

High

1439541

SL9A8
Sodium/hydrogen exchanger 8

1

4

High-throughput

0.407

High

1439544

PCDGH
Protocadherin gamma-B5

1

19

High-throughput

0.407

High

1394987

VCIP1
Deubiquitinating protein VCPIP1

2

0

High-throughput

0.328

High

1421064

ZY11B
Protein zyg-11 homolog B

2

0

High-throughput

0.328

High

1207624

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

1324730

CBARP
Voltage-dependent calcium channel beta subunit-associated regulatory protein

2

0

High-throughput

0.316

High

1365984

APBP2
Amyloid protein-binding protein 2

2

0

High-throughput

0.316

High

1439527

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

833561

BUD31
Protein BUD31 homolog

1

0

High-throughput

0.282

High

639350

SCF
Kit ligand

1

0

High-throughput

0.279

Low

1257315

RHEX
Regulator of hemoglobinization and erythroid cell expansion protein

1

0

High-throughput

0.279

Low

1359414

KCNE4
Potassium voltage-gated channel subfamily E member 4

1

0

High-throughput

0.279

Low

1435540

SPRNG
SREBP regulating gene protein

1

0

High-throughput

0.279

Low

1439525

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.279

Low

1102456

BIK
Bcl-2-interacting killer

1

0

High-throughput

0.251

Low

623553

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.249

Low

1346940

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.249

Low

1208282

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025