Protein: SC5A3
Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3)

Gene: SC5A3, SLC5A3
Organism: Homo sapiens
Interactions: 69
UniProt ID: P53794

Gene Ontology (top 5):
GO:0005365 - myo-inositol transmembrane transporter activity
GO:0005367 - myo-inositol:sodium symporter activity
GO:0005412 - D-glucose:sodium symporter activity
GO:0005886 - plasma membrane
GO:0006020 - inositol metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

923449

SC5A6
Sodium-dependent multivitamin transporter

1

6

High-throughput

0.575

High

770836

OPRM
Mu-type opioid receptor

2

3

High-throughput

0.552

High

771105

APJ
Apelin receptor

2

2

High-throughput

0.552

High

835259

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

2

High-throughput

0.552

High

923436

P2Y12
P2Y purinoceptor 12

2

3

High-throughput

0.552

High

923423

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

2

0

High-throughput

0.528

High

182498

GP182
G-protein coupled receptor 182

1

5

High-throughput

0.445

High

184147

RER1
Protein RER1

1

3

High-throughput

0.445

High

184417

SURF4
Surfeit locus protein 4

1

1

High-throughput

0.445

High

618375

TSN8
Tetraspanin-8

1

4

High-throughput

0.445

High

640378

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

4

High-throughput

0.445

High

668982

FPR2
N-formyl peptide receptor 2

1

5

High-throughput

0.445

High

690206

STOM
Stomatin

1

1

High-throughput

0.445

High

693396

CERS1
Ceramide synthase 1

1

2

High-throughput

0.445

High

709259

AA2BR
Adenosine receptor A2b

1

2

High-throughput

0.445

High

719770

V2R
Vasopressin V2 receptor

1

3

High-throughput

0.445

High

867607

GPR12
G-protein coupled receptor 12

1

3

High-throughput

0.445

High

867951

GLR
Glucagon receptor

1

2

High-throughput

0.445

High

923411

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

3

High-throughput

0.445

High

923414

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

3

High-throughput

0.445

High

923415

GALT3
Polypeptide N-acetylgalactosaminyltransferase 3

1

1

High-throughput

0.445

High

923429

AQP3
Aquaporin-3

1

3

High-throughput

0.445

High

923431

CREL1
Protein disulfide isomerase CRELD1

1

1

High-throughput

0.445

High

923446

DHCR7
7-dehydrocholesterol reductase

1

2

High-throughput

0.445

High

923451

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.445

High

130049

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.426

High

162178

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.426

High

172608

XPO1
Exportin-1

1

0

High-throughput

0.426

High

469039

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.426

High

574086

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

0

High-throughput

0.426

High

789882

FDFT
Squalene synthase

1

0

High-throughput

0.426

High

923409

IOD3
Thyroxine 5-deiodinase

1

0

High-throughput

0.426

High

923412

AT2C1
Calcium-transporting ATPase type 2C member 1

1

0

High-throughput

0.426

High

923413

LMAN2
Vesicular integral-membrane protein VIP36

1

0

High-throughput

0.426

High

923416

RB39A
Ras-related protein Rab-39A

1

0

High-throughput

0.426

High

923420

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.426

High

923421

T184A
Transmembrane protein 184A

1

0

High-throughput

0.426

High

923422

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.426

High

923425

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.426

High

923427

OR4N2
Olfactory receptor 4N2

1

0

High-throughput

0.426

High

923428

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.426

High

923430

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.426

High

923432

CLP1L
Lipid scramblase CLPTM1L

1

0

High-throughput

0.426

High

923433

DNJC1
DnaJ homolog subfamily C member 1

1

0

High-throughput

0.426

High

923434

CCG6
Voltage-dependent calcium channel gamma-6 subunit

1

0

High-throughput

0.426

High

923435

GPR88
G protein-coupled receptor 88

1

0

High-throughput

0.426

High

923437

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.426

High

923441

GP173
Probable G-protein coupled receptor 173

1

0

High-throughput

0.426

High

923442

T161A
Transmembrane protein 161A

1

0

High-throughput

0.426

High

923445

ATX10
Ataxin-10

1

0

High-throughput

0.426

High

923447

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.426

High

923448

PLAT4
Phospholipase A and acyltransferase 4

1

0

High-throughput

0.426

High

170714

CLGN
Calmegin

1

2

High-throughput

0.407

High

268996

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

1

2

High-throughput

0.407

High

923410

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

1

High-throughput

0.407

High

923419

S35F1
Solute carrier family 35 member F1

1

1

High-throughput

0.407

High

923439

S61A2
Protein transport protein Sec61 subunit alpha isoform 2

1

3

High-throughput

0.407

High

923444

CNIH4
Protein cornichon homolog 4

1

1

High-throughput

0.407

High

923450

TBL2
Transducin beta-like protein 2

1

1

High-throughput

0.407

High

923426

SPX3
Sugar phosphate exchanger 3

2

0

High-throughput

0.288

High

321969

NFAT5
Nuclear factor of activated T-cells 5

1

0

Small-scale

0.249

Low

280162

SC22B
Vesicle-trafficking protein SEC22b

1

0

High-throughput

0.232

Low

299631

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

0

High-throughput

0.232

Low

923417

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.232

Low

923418

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.232

Low

923424

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.232

Low

923438

TFB2M
Dimethyladenosine transferase 2, mitochondrial

1

0

High-throughput

0.232

Low

923440

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

1

0

High-throughput

0.232

Low

923443

CISD1
CDGSH iron-sulfur domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025