Protein: FOXO
Forkhead box protein O (FOXO) (Abnormal dauer formation protein 16)

Gene: FOXO, daf-16
Organism: Caenorhabditis elegans
Interactions: 67
UniProt ID: O16850

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0002119 - nematode larval development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

184241

14332
14-3-3-like protein 2

4

20

Small-scale

0.677

High

184231

AKT1
Serine/threonine-protein kinase akt-1

2

11

Small-scale

0.666

High

184245

SGK1
Serine/threonine-protein kinase sgk-1

2

13

Small-scale

0.666

High

184261

AKT2
Serine/threonine-protein kinase akt-2

2

12

Small-scale

0.666

High

184230

PHA4
Defective pharyngeal development protein 4

1

20

High-throughput

0.656

High

184222

14331
14-3-3-like protein 1

3

20

Small-scale

0.640

High

184243

SIR2
NAD-dependent protein deacetylase sir-2.1

2

13

Small-scale

0.612

High

184221

CBP1
Protein cbp-1

2

20

Small-scale

0.594

High

184213

RLE1
Regulation of longevity by E3 ubiquitin-protein ligase

1

2

Small-scale

0.561

High

184247

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

8

Small-scale

0.561

High

184249

JNK1
Stress-activated protein kinase jnk-1

1

4

Small-scale

0.561

High

184255

Q9N5V3
Importin N-terminal domain-containing protein

1

5

High-throughput

0.560

High

184223

SMA3
Dwarfin sma-3

1

18

Small-scale

0.552

High

184227

SMA2
Dwarfin sma-2

1

18

Small-scale

0.552

High

184215

KCC2D
Calcium/calmodulin-dependent protein kinase type II

1

0

Small-scale

0.537

High

184228

EGL27
Egg-laying defective protein 27

1

12

Small-scale

0.536

High

184212

RN113
Probable E3 ubiquitin-protein ligase rnf113

1

0

High-throughput

0.518

High

60829

SIN3
Paired amphipathic helix protein sin-3

1

2

High-throughput

0.508

High

105785

PAX3H
Paired box protein 3 homolog

1

20

High-throughput

0.508

High

184214

KLF2
Kruppel-like factor 2

1

19

High-throughput

0.508

High

184234

NHR43
Nuclear hormone receptor family member nhr-43

1

20

High-throughput

0.508

High

184237

ZTF2
Zinc finger protein ztf-2

1

5

High-throughput

0.508

High

184246

NU301
Nucleosome-remodeling factor subunit NURF301-like

1

20

High-throughput

0.508

High

184256

TBX39
Putative T-box protein 39

1

10

High-throughput

0.508

High

184262

Q9XVN4
Homeobox domain-containing protein

1

20

High-throughput

0.508

High

184263

Q9XWK6
C2H2-type domain-containing protein

1

1

High-throughput

0.508

High

184252

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

Small-scale

0.501

High

184226

PFD6
Probable prefoldin subunit 6

1

0

Small-scale

0.493

High

184244

Q22826
Fork-head domain-containing protein

1

0

High-throughput

0.486

High

184257

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.486

High

109944

H2KZU3
NR LBD domain-containing protein

1

20

High-throughput

0.481

High

137385

O02174
C3H1-type domain-containing protein

1

1

High-throughput

0.481

High

184248

Q86PI8
Nuclear receptor NHR-114

1

20

High-throughput

0.481

High

104666

HCF1
Host cell factor homolog hcf-1

1

4

Small-scale

0.479

High

110890

H8ESF3
SWI/SNF complex subunit SMARCC2

1

8

Small-scale

0.479

High

110942

H9G2X3
Serine/threonine protein phosphatase 2A regulatory subunit

1

1

Small-scale

0.479

High

184216

O62332
Importin N-terminal domain-containing protein

1

4

Small-scale

0.479

High

184218

MLR2
Myosin regulatory light chain 2

1

2

Small-scale

0.479

High

184219

CSK2B
Casein kinase II subunit beta

1

1

Small-scale

0.479

High

184232

RCC1
Regulator of chromosome condensation

1

8

Small-scale

0.479

High

184235

BAR1
Beta-catenin/armadillo-related protein 1

1

12

Small-scale

0.479

High

184236

Q19007
Nucleosome assembly protein 1-like 1

1

4

Small-scale

0.479

High

184238

RFA1
Probable replication factor A 73 kDa subunit

1

1

Small-scale

0.479

High

184239

VRK1
Serine/threonine-protein kinase VRK1

1

13

Small-scale

0.479

High

184240

KIN20
Casein kinase I isoform delta

1

5

Small-scale

0.479

High

184242

TDX1
Probable peroxiredoxin prdx-3

1

4

Small-scale

0.479

High

184250

Q95PZ7
Proteasome activator complex subunit 3

1

2

Small-scale

0.479

High

184251

SIR24
NAD-dependent protein deacetylase sir-2.4

1

13

Small-scale

0.479

High

184259

ANM1
Protein arginine N-methyltransferase 1

1

4

Small-scale

0.479

High

106196

HMG12
High mobility group protein hmg-12

1

0

Small-scale

0.458

High

184229

ADRM1
Proteasomal ubiquitin receptor ADRM1 homolog

1

0

Small-scale

0.458

High

106942

NH114
Nuclear hormone receptor 114

1

20

High-throughput

0.457

High

109848

H2KZI6
C3H1-type domain-containing protein

1

1

High-throughput

0.457

High

109967

H2KZU4
NR LBD domain-containing protein

1

20

High-throughput

0.457

High

184233

DX39B
Spliceosome RNA helicase DDX39B homolog

1

11

Small-scale

0.445

High

184258

TAF12
Transcription initiation factor TFIID subunit 12

1

0

High-throughput

0.438

High

184217

ACT4
Actin-4

1

1

Small-scale

0.437

High

184220

MTSS1
Single-stranded DNA-binding protein, mitochondrial

1

1

Small-scale

0.437

High

184224

TCPB
T-complex protein 1 subunit beta

1

1

Small-scale

0.437

High

184225

TCPD
T-complex protein 1 subunit delta

1

1

Small-scale

0.437

High

184253

Q9BL39
HMG box domain-containing protein

1

20

Small-scale

0.437

High

184254

TCPQ
T-complex protein 1 subunit theta

1

1

Small-scale

0.437

High

184260

Q9UAY9
DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein

1

1

Small-scale

0.437

High

184264

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

Small-scale

0.437

High

106163

CANB
Protein phosphatase 2B regulatory subunit cnb-1

1

0

Small-scale

0.249

Low

184071

O16689
OB domain-containing protein

1

0

Small-scale

0.249

Low

64384

A6ZJ46
SH3 domain-containing protein

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024