Protein: RFWD3
E3 ubiquitin-protein ligase RFWD3 (EC 2.3.2.27) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201)

Gene: RFWD3
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q6PCD5

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0002039 - p53 binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

906679

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

20

High-throughput

0.815

High

957103

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

High-throughput

0.815

High

982212

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

High-throughput

0.815

High

1243733

UB2D4
Ubiquitin-conjugating enzyme E2 D4

2

20

High-throughput

0.815

High

695739

RFA1
Replication protein A 70 kDa DNA-binding subunit

10

3

Small-scale

0.754

High

588953

RFA2
Replication protein A 32 kDa subunit

10

0

Small-scale

0.724

High

909328

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

957761

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

High-throughput

0.698

High

1243711

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.698

High

1243712

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

768460

RFA3
Replication protein A 14 kDa subunit

6

0

Small-scale

0.697

High

1243717

TCPH
T-complex protein 1 subunit eta

3

8

High-throughput

0.675

High

679353

DNJB2
DnaJ homolog subfamily B member 2

3

3

High-throughput

0.667

High

1243705

RFWD3
E3 ubiquitin-protein ligase RFWD3

1

17

Small-scale

0.665

High

508151

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

15

High-throughput

0.647

High

1243725

MBIP1
MAP3K12-binding inhibitory protein 1

3

0

High-throughput

0.638

High

871957

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

2

High-throughput

0.628

High

1243716

KCC1G
Calcium/calmodulin-dependent protein kinase type 1G

2

4

High-throughput

0.628

High

242031

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.618

High

1007088

TCPB
T-complex protein 1 subunit beta

3

9

High-throughput

0.604

High

1243707

BBS7
BBSome complex member BBS7

2

0

High-throughput

0.602

High

1028245

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.597

High

414044

P53
Cellular tumor antigen p53

1

5

Small-scale

0.586

High

1055926

RAD51
DNA repair protein RAD51 homolog 1

1

1

Small-scale

0.586

High

876025

TCPE
T-complex protein 1 subunit epsilon

2

8

High-throughput

0.574

High

551107

PCNA
Proliferating cell nuclear antigen

1

1

Small-scale

0.561

High

1104317

ORC1
Origin recognition complex subunit 1

1

1

Small-scale

0.561

High

1104350

ORC2
Origin recognition complex subunit 2

1

1

Small-scale

0.561

High

1210878

CE170
Centrosomal protein of 170 kDa

2

6

High-throughput

0.558

High

1243724

DISC1
Disrupted in schizophrenia 1 protein

2

2

High-throughput

0.549

High

563929

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.541

High

258945

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.536

High

532686

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.536

High

573531

ENPL
Endoplasmin

1

7

High-throughput

0.536

High

821415

TCPZ
T-complex protein 1 subunit zeta

1

6

High-throughput

0.536

High

899093

TCPQ
T-complex protein 1 subunit theta

1

9

High-throughput

0.536

High

899442

TCPD
T-complex protein 1 subunit delta

1

7

High-throughput

0.536

High

1243706

TRI74
Tripartite motif-containing protein 74

1

18

High-throughput

0.536

High

1243709

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

2

High-throughput

0.536

High

1243720

RNF41
E3 ubiquitin-protein ligase NRDP1

1

20

High-throughput

0.536

High

1243726

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.536

High

1105625

GOGA4
Golgin subfamily A member 4

1

13

High-throughput

0.515

High

1243722

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

16

High-throughput

0.515

High

1243715

PRIPO
DNA-directed primase/polymerase protein

1

0

Small-scale

0.513

High

1243729

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.513

High

422360

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

300776

KRT38
Keratin, type I cuticular Ha8

1

1

High-throughput

0.489

High

610723

TCPA
T-complex protein 1 subunit alpha

1

6

High-throughput

0.489

High

698776

CALX
Calnexin

1

5

High-throughput

0.489

High

881987

TCPG
T-complex protein 1 subunit gamma

1

8

High-throughput

0.489

High

1243710

GSLG1
Golgi apparatus protein 1

1

3

High-throughput

0.489

High

1243732

E41L3
Band 4.1-like protein 3

1

1

High-throughput

0.489

High

1243734

HYOU1
Hypoxia up-regulated protein 1

1

7

High-throughput

0.489

High

172959

XPO1
Exportin-1

1

16

High-throughput

0.479

High

261825

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.479

High

461603

HS90A
Heat shock protein HSP 90-alpha

1

8

High-throughput

0.479

High

468506

HS90B
Heat shock protein HSP 90-beta

1

9

High-throughput

0.479

High

851595

GATA4
Transcription factor GATA-4

1

11

High-throughput

0.479

High

979848

H4
Histone H4

1

6

High-throughput

0.479

High

995089

CSK2B
Casein kinase II subunit beta

1

4

High-throughput

0.479

High

1202194

DCAF6
DDB1- and CUL4-associated factor 6

1

10

High-throughput

0.479

High

1243708

RPTOR
Regulatory-associated protein of mTOR

1

14

High-throughput

0.479

High

1243713

RNF31
E3 ubiquitin-protein ligase RNF31

1

6

High-throughput

0.479

High

1243721

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

1243723

MBNL1
Muscleblind-like protein 1

1

3

High-throughput

0.479

High

1243728

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

1

Small-scale

0.479

High

1243730

XPO7
Exportin-7

1

14

High-throughput

0.479

High

1243731

PRP19
Pre-mRNA-processing factor 19

1

9

Small-scale

0.479

High

91806

C9JP00
Muscleblind like splicing regulator 1

1

3

High-throughput

0.445

High

1243718

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.437

High

1243727

MS18A
Protein Mis18-alpha

1

0

High-throughput

0.426

High

95771

E5RGS4
Prefoldin subunit 1

1

1

High-throughput

0.407

High

1243714

C170L
Cep170-like protein

1

2

High-throughput

0.407

High

607894

TPH1
Tryptophan 5-hydroxylase 1

2

0

High-throughput

0.328

High

961534

VA0D1
V-type proton ATPase subunit d 1

1

0

High-throughput

0.279

Low

1243719

COA1
Cytochrome c oxidase assembly factor 1 homolog

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025