Protein: AGRG5
Adhesion G-protein coupled receptor G5 (G-protein coupled receptor 114) (G-protein coupled receptor PGR27) [Cleaved into: Adhesion G-protein coupled receptor G5, N-terminal fragment (ADGRG5 N-terminal fragment); Adhesion G-protein coupled receptor G5, C-terminal fragment (ADGRG5 C-terminal fragment)]

Gene: AGRG5, ADGRG5
Organism: Homo sapiens
Interactions: 149
UniProt ID: Q8IZF4

Gene Ontology (top 5):
GO:0004930 - G protein-coupled receptor activity
GO:0005886 - plasma membrane
GO:0007166 - cell surface receptor signaling pathway
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

604087

CXA1
Gap junction alpha-1 protein

3

4

High-throughput

0.662

High

698867

CALX
Calnexin

3

9

High-throughput

0.662

High

783047

CXG1
Gap junction gamma-1 protein

3

4

High-throughput

0.662

High

787315

ACV1B
Activin receptor type-1B

3

3

High-throughput

0.662

High

1248623

LCLT1
Lysocardiolipin acyltransferase 1

3

1

High-throughput

0.662

High

1293256

LSR
Lipolysis-stimulated lipoprotein receptor

3

1

High-throughput

0.662

High

1316343

ASTRA
Protein Aster-A

3

1

High-throughput

0.662

High

1316379

AT133
Polyamine-transporting ATPase 13A3

3

4

High-throughput

0.662

High

1316398

ZNT1
Proton-coupled zinc antiporter SLC30A1

3

9

High-throughput

0.662

High

1195356

ANO6
Anoctamin-6

3

0

High-throughput

0.634

High

1316356

SGMR1
Sigma non-opioid intracellular receptor 1

3

0

High-throughput

0.634

High

1316361

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

3

0

High-throughput

0.634

High

1316377

ALG9
Alpha-1,2-mannosyltransferase ALG9

3

0

High-throughput

0.634

High

62142

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

10

High-throughput

0.628

High

252695

TSN3
Tetraspanin-3

2

13

High-throughput

0.628

High

256079

S19A2
Thiamine transporter 1

2

3

High-throughput

0.628

High

720421

ACHA5
Neuronal acetylcholine receptor subunit alpha-5

2

5

High-throughput

0.628

High

787201

BMR1A
Bone morphogenetic protein receptor type-1A

2

3

High-throughput

0.628

High

906903

GPM6A
Neuronal membrane glycoprotein M6-a

2

3

High-throughput

0.628

High

931814

EPHB3
Ephrin type-B receptor 3

2

8

High-throughput

0.628

High

1125859

FZD2
Frizzled-2

2

6

High-throughput

0.628

High

1186409

ASTRB
Protein Aster-B

2

1

High-throughput

0.628

High

1278284

LRP10
Low-density lipoprotein receptor-related protein 10

2

1

High-throughput

0.628

High

1316327

SIDT2
SID1 transmembrane family member 2

2

1

High-throughput

0.628

High

1316328

MSPD2
Motile sperm domain-containing protein 2

2

1

High-throughput

0.628

High

1316332

SPPL3
Signal peptide peptidase-like 3

2

4

High-throughput

0.628

High

1316357

ABCA3
Phospholipid-transporting ATPase ABCA3

2

1

High-throughput

0.628

High

1316358

S29A1
Equilibrative nucleoside transporter 1

2

2

High-throughput

0.628

High

1316363

SGPP1
Sphingosine-1-phosphate phosphatase 1

2

1

High-throughput

0.628

High

1316364

S12A9
Solute carrier family 12 member 9

2

10

High-throughput

0.628

High

1316371

TSN10
Tetraspanin-10

2

14

High-throughput

0.628

High

1316382

FZD3
Frizzled-3

2

6

High-throughput

0.628

High

1316385

SERC1
Serine incorporator 1

2

2

High-throughput

0.628

High

1316392

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

1

High-throughput

0.628

High

1316396

FLVC1
Choline/ethanolamine transporter FLVCR1

2

1

High-throughput

0.628

High

1107522

GPM6B
Neuronal membrane glycoprotein M6-b

2

3

High-throughput

0.611

High

1316348

REEP6
Receptor expression-enhancing protein 6

3

1

High-throughput

0.604

High

1316370

TMX4
Thioredoxin-related transmembrane protein 4

3

2

High-throughput

0.604

High

582181

INGR1
Interferon gamma receptor 1

2

0

High-throughput

0.602

High

1231437

ATLA3
Atlastin-3

2

0

High-throughput

0.602

High

1233986

ASPH2
Aspartate beta-hydroxylase domain-containing protein 2

2

0

High-throughput

0.602

High

1245204

BRAT1
Integrator complex assembly factor BRAT1

2

0

High-throughput

0.602

High

1247737

PLPR3
Phospholipid phosphatase-related protein type 3

2

0

High-throughput

0.602

High

1316349

DIESL
DGAT1/2-independent enzyme synthesizing storage lipids

2

0

High-throughput

0.602

High

1316360

ABHEA
Protein ABHD14A

2

0

High-throughput

0.602

High

1316367

OSBL8
Oxysterol-binding protein-related protein 8

2

0

High-throughput

0.602

High

247525

FZD6
Frizzled-6

2

6

High-throughput

0.601

High

1316334

PIGO
GPI ethanolamine phosphate transferase 3, catalytic subunit

2

5

High-throughput

0.601

High

1316347

CREL1
Protein disulfide isomerase CRELD1

2

3

High-throughput

0.601

High

1316365

TMM59
Transmembrane protein 59

2

1

High-throughput

0.601

High

1316397

AGRG1
Adhesion G-protein coupled receptor G1

1

5

High-throughput

0.575

High

399712

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

2

2

High-throughput

0.574

High

611222

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

1

High-throughput

0.574

High

1310689

TRI59
Tripartite motif-containing protein 59

2

1

High-throughput

0.574

High

1316329

MFSD8
Major facilitator superfamily domain-containing protein 8

2

4

High-throughput

0.574

High

1316373

PIGM
GPI alpha-1,4-mannosyltransferase I, catalytic subunit

2

1

High-throughput

0.574

High

1316380

DJC18
DnaJ homolog subfamily C member 18

2

4

High-throughput

0.574

High

1316394

TMED7
Transmembrane emp24 domain-containing protein 7

2

3

High-throughput

0.574

High

1316324

CADM3
Cell adhesion molecule 3

1

0

High-throughput

0.546

High

226438

SNG2
Synaptogyrin-2

1

2

High-throughput

0.536

High

420014

B3A2
Anion exchange protein 2

1

3

High-throughput

0.536

High

727535

SC6A6
Sodium- and chloride-dependent taurine transporter

1

5

High-throughput

0.536

High

773924

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.536

High

1105751

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

1

High-throughput

0.536

High

1111507

MTR1L
Melatonin-related receptor

1

8

High-throughput

0.536

High

1116824

AVR2B
Activin receptor type-2B

1

3

High-throughput

0.536

High

1206091

TGO1
Transport and Golgi organization protein 1 homolog

1

1

High-throughput

0.536

High

1251725

CERS6
Ceramide synthase 6

1

3

High-throughput

0.536

High

1316333

SPP2B
Signal peptide peptidase-like 2B

1

4

High-throughput

0.536

High

1316345

S47A1
Multidrug and toxin extrusion protein 1

1

1

High-throughput

0.536

High

1316350

VMA22
Vacuolar ATPase assembly protein VMA22

1

1

High-throughput

0.536

High

1316387

S39A1
Zinc transporter ZIP1

1

11

High-throughput

0.536

High

536271

PPAL
Lysosomal acid phosphatase

1

0

High-throughput

0.513

High

834679

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

0

High-throughput

0.513

High

1281735

T179B
Transmembrane protein 179B

1

0

High-throughput

0.513

High

1316336

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.513

High

1316338

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

0

High-throughput

0.513

High

1316376

XKR8
XK-related protein 8

1

0

High-throughput

0.513

High

1316386

MITOS
Mitochondrial potassium channel ATP-binding subunit

1

0

High-throughput

0.513

High

1006537

SRPK2
SRSF protein kinase 2

1

2

High-throughput

0.502

High

212076

B4GT5
Beta-1,4-galactosyltransferase 5

1

1

High-throughput

0.489

High

1316339

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

1

High-throughput

0.489

High

85175

B7Z613
Glycoprotein M6B

1

3

High-throughput

0.445

High

184474

SURF4
Surfeit locus protein 4

1

1

High-throughput

0.445

High

270665

ATP9A
Probable phospholipid-transporting ATPase IIA

1

1

High-throughput

0.445

High

336550

PIGN
GPI ethanolamine phosphate transferase 1

1

5

High-throughput

0.445

High

480847

LEG1
Galectin-1

1

3

High-throughput

0.445

High

787422

TGFR1
TGF-beta receptor type-1

1

3

High-throughput

0.445

High

933435

S12A2
Solute carrier family 12 member 2

1

5

High-throughput

0.445

High

1089976

LMAN2
Vesicular integral-membrane protein VIP36

1

1

High-throughput

0.445

High

1098438

DNJC3
DnaJ homolog subfamily C member 3

1

3

High-throughput

0.445

High

1110803

PKD2
Polycystin-2

1

5

High-throughput

0.445

High

1127625

SCN5A
Sodium channel protein type 5 subunit alpha

1

8

High-throughput

0.445

High

1154810

KCNJ8
ATP-sensitive inward rectifier potassium channel 8

1

1

High-throughput

0.445

High

1159156

SGCB
Beta-sarcoglycan

1

1

High-throughput

0.445

High

1204575

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

5

High-throughput

0.445

High

1259086

ILDR2
Immunoglobulin-like domain-containing receptor 2

1

1

High-throughput

0.445

High

1310824

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

3

High-throughput

0.445

High

1316331

GOGA5
Golgin subfamily A member 5

1

4

High-throughput

0.445

High

1316351

MIA2
Melanoma inhibitory activity protein 2

1

4

High-throughput

0.445

High

1316352

S38A2
Sodium-coupled neutral amino acid symporter 2

1

1

High-throughput

0.445

High

1316368

YIPF3
Protein YIPF3

1

2

High-throughput

0.445

High

1316369

LMA2L
VIP36-like protein

1

1

High-throughput

0.445

High

1316381

SDF2L
Stromal cell-derived factor 2-like protein 1

1

4

High-throughput

0.445

High

1316391

SEC63
Translocation protein SEC63 homolog

1

3

High-throughput

0.445

High

1316395

PCDBB
Protocadherin beta-11

1

10

High-throughput

0.445

High

133537

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.426

High

292684

RENR
Renin receptor

1

0

High-throughput

0.426

High

300012

CBPD
Carboxypeptidase D

1

0

High-throughput

0.426

High

852650

ABCG1
ATP-binding cassette sub-family G member 1

1

0

High-throughput

0.426

High

1309785

IPRI
Inositol 1,4,5-trisphosphate receptor-interacting protein

1

0

High-throughput

0.426

High

1316330

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.426

High

1316346

RUSF1
RUS family member 1

1

0

High-throughput

0.426

High

1316353

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.426

High

1316374

GOLP3
Golgi phosphoprotein 3

1

0

High-throughput

0.426

High

1316378

ANTR1
Anthrax toxin receptor 1

1

0

High-throughput

0.426

High

1316384

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.426

High

170861

CLGN
Calmegin

1

9

High-throughput

0.407

High

193710

TPSN
Tapasin

1

5

High-throughput

0.407

High

299882

C1QRF
C1q-related factor

1

6

High-throughput

0.407

High

1027074

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.407

High

1203379

YIF1B
Protein YIF1B

1

1

High-throughput

0.407

High

1239805

MZT2B
Mitotic-spindle organizing protein 2B

1

1

High-throughput

0.407

High

1316325

MACOI
Macoilin

1

2

High-throughput

0.407

High

1316340

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.407

High

1316354

SDF2
Stromal cell-derived factor 2

1

4

High-throughput

0.407

High

1316372

TMX1
Thioredoxin-related transmembrane protein 1

1

1

High-throughput

0.407

High

1316383

TMM9B
Transmembrane protein 9B

1

4

High-throughput

0.407

High

1316389

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

4

High-throughput

0.407

High

1316393

DJC16
DnaJ homolog subfamily C member 16

1

3

High-throughput

0.407

High

1316362

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

3

0

High-throughput

0.345

High

1087064

FSTL1
Follistatin-related protein 1

2

0

High-throughput

0.328

High

1316326

FITM2
Acyl-coenzyme A diphosphatase FITM2

2

0

High-throughput

0.328

High

1316359

PXL2A
Peroxiredoxin-like 2A

2

0

High-throughput

0.328

High

1316366

SC11C
Signal peptidase complex catalytic subunit SEC11C

2

0

High-throughput

0.328

High

1316375

SG196
Protein O-mannose kinase

2

0

High-throughput

0.328

High

1245599

TXD11
Thioredoxin domain-containing protein 11

1

0

High-throughput

0.279

Low

1276012

D19L4
Probable C-mannosyltransferase DPY19L4

1

0

High-throughput

0.279

Low

1316337

FAM3C
Protein FAM3C

1

0

High-throughput

0.279

Low

1316341

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

1316344

NGBR
Dehydrodolichyl diphosphate synthase complex subunit NUS1

1

0

High-throughput

0.279

Low

350551

CF047
Uncharacterized protein C6orf47

1

0

High-throughput

0.232

Low

402389

GBA1
Lysosomal acid glucosylceramidase

1

0

High-throughput

0.232

Low

1214099

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.232

Low

1316335

THEM6
Protein THEM6

1

0

High-throughput

0.232

Low

1316342

RHDF1
Inactive rhomboid protein 1

1

0

High-throughput

0.232

Low

1316355

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.232

Low

1316388

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

High-throughput

0.232

Low

1316390

AASS
Alpha-aminoadipic semialdehyde synthase, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025