Protein: COX5A
Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)

Gene: COX5A
Organism: Homo sapiens
Interactions: 170
UniProt ID: P20674

Gene Ontology (top 5):
GO:0004129 - cytochrome-c oxidase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005758 - mitochondrial intermembrane space
GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

559864

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

4

1

High-throughput

0.895

High

485839

COX6C
Cytochrome c oxidase subunit 6C

2

0

Small-scale

0.699

High

634158

COX42
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

1

1

High-throughput

0.691

High

634121

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

3

0

High-throughput

0.634

High

634115

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

3

0

Small-scale

0.613

High

634075

VDAC1
Non-selective voltage-gated ion channel VDAC1

2

1

High-throughput

0.611

High

156190

CO72L
Cytochrome c oxidase subunit 7A2-like, mitochondrial

2

0

High-throughput

0.602

High

279646

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

634199

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

2

0

Small-scale

0.547

High

360248

COX1
Cytochrome c oxidase subunit 1

1

1

High-throughput

0.536

High

634113

K1H1
Keratin, type I cuticular Ha1

1

1

High-throughput

0.523

High

634119

K1C40
Keratin, type I cytoskeletal 40

1

1

High-throughput

0.523

High

395481

ESR1
Estrogen receptor

2

2

High-throughput

0.521

High

634090

RHOA
Transforming protein RhoA

2

2

High-throughput

0.521

High

209478

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.513

High

421485

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.493

High

593813

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

1

High-throughput

0.489

High

634079

CLIP1
CAP-Gly domain-containing linker protein 1

1

1

High-throughput

0.489

High

634092

RAC1
Ras-related C3 botulinum toxin substrate 1

1

2

High-throughput

0.489

High

274977

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.479

High

281881

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

287237

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

292076

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.479

High

634080

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.479

High

634082

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

634087

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

634088

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

634100

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

634114

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

634136

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

634144

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

1

High-throughput

0.479

High

634145

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

1

1

High-throughput

0.479

High

634146

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

634148

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

634154

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

1

High-throughput

0.479

High

634159

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

1

High-throughput

0.479

High

634160

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

634162

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

634174

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

634176

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

2

High-throughput

0.479

High

634178

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

634191

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

634194

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

634203

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

1

High-throughput

0.479

High

137648

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

216625

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

240734

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

245418

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

High-throughput

0.458

High

296193

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

348360

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

350785

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

505414

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

617470

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.458

High

634081

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

634084

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

634086

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

634094

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

634098

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

634099

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

634101

ACACA
Acetyl-CoA carboxylase 1

1

0

High-throughput

0.458

High

634104

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

0

Small-scale

0.458

High

634106

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

634107

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

634123

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

634128

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.458

High

634147

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

634150

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.458

High

634151

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

634152

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

634153

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

634157

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

634161

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

634163

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.458

High

634164

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

634165

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

634166

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

634167

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

634168

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

634172

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

634173

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

634177

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

634179

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

634180

OPA3
Optic atrophy 3 protein

1

0

High-throughput

0.458

High

634181

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

634182

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

634183

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

634185

PLRKT
Plasminogen receptor

1

0

High-throughput

0.458

High

634189

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

634190

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

634192

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

634193

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

634200

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

634096

CX6A2
Cytochrome c oxidase subunit 6A2, mitochondrial

1

1

Small-scale

0.445

High

169944

AURKA
Aurora kinase A

1

1

High-throughput

0.437

High

371148

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

403816

GCR
Glucocorticoid receptor

1

2

High-throughput

0.437

High

405783

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

634089

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

1

High-throughput

0.437

High

634095

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.437

High

634097

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.437

High

634131

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

634156

AURKB
Aurora kinase B

1

1

High-throughput

0.437

High

634184

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.437

High

634188

DNJC4
DnaJ homolog subfamily C member 4

1

2

High-throughput

0.437

High

529063

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

469411

ELNE
Neutrophil elastase

1

1

Small-scale

0.417

High

634117

MYOME
Myomegalin

1

1

Small-scale

0.417

High

104105

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

189975

MOT7
Monocarboxylate transporter 7

1

1

High-throughput

0.407

High

634085

HD
Huntingtin

1

1

High-throughput

0.407

High

634093

S35B1
Solute carrier family 35 member B1

1

1

High-throughput

0.407

High

634140

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

1

High-throughput

0.407

High

634142

S35G2
Solute carrier family 35 member G2

1

2

High-throughput

0.407

High

634197

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.407

High

634102

G3BP1
Ras GTPase-activating protein-binding protein 1

2

0

High-throughput

0.328

High

331499

SPDEF
SAM pointed domain-containing Ets transcription factor

2

0

High-throughput

0.316

High

634108

MESD
LRP chaperone MESD

2

0

High-throughput

0.316

High

634149

EXOS8
Exosome complex component RRP43

1

0

High-throughput

0.299

High

634137

DOCK8
Dedicator of cytokinesis protein 8

2

0

High-throughput

0.298

High

634124

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.282

High

184115

RER1
Protein RER1

1

0

High-throughput

0.279

Low

250454

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.279

Low

369016

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.279

Low

634074

LMNB1
Lamin-B1

1

0

High-throughput

0.279

Low

634076

BRD2
Bromodomain-containing protein 2

1

0

High-throughput

0.279

Low

634078

BLVRB
Flavin reductase

1

0

High-throughput

0.279

Low

634110

KIF22
Kinesin-like protein KIF22

1

0

High-throughput

0.279

Low

634125

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

634126

URP2
Fermitin family homolog 3

1

0

High-throughput

0.279

Low

634134

PAF1
RNA polymerase II-associated factor 1 homolog

1

0

High-throughput

0.279

Low

634135

KDM1B
Lysine-specific histone demethylase 2

1

0

High-throughput

0.279

Low

634171

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

634175

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

634187

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.279

Low

634201

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.279

Low

634202

RPGF2
Rap guanine nucleotide exchange factor 2

1

0

High-throughput

0.279

Low

634077

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

High-throughput

0.268

Low

634169

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.261

Low

332739

EPM2A
Laforin

1

0

Small-scale

0.251

Low

105316

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

222712

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.249

Low

606210

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

634091

H4
Histone H4

1

0

High-throughput

0.249

Low

634103

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.249

Low

634105

CUL3
Cullin-3

1

0

High-throughput

0.249

Low

634111

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

634112

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

634116

MIDN
Midnolin

1

0

High-throughput

0.249

Low

634118

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

634122

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

634127

SL9A9
Sodium/hydrogen exchanger 9

1

0

Small-scale

0.249

Low

634129

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.249

Low

634130

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.249

Low

634133

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.249

Low

634138

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.249

Low

634139

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

634141

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

634143

DUS19
Dual specificity protein phosphatase 19

1

0

High-throughput

0.249

Low

634186

LFG4
Protein lifeguard 4

1

0

High-throughput

0.249

Low

634195

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

634196

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.249

Low

255976

S19A2
Thiamine transporter 1

1

0

High-throughput

0.232

Low

404661

PRIO
Major prion protein

1

0

High-throughput

0.232

Low

634083

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.232

Low

634109

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.232

Low

634120

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

634132

SVOP
Synaptic vesicle 2-related protein

1

0

High-throughput

0.232

Low

634155

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.232

Low

634170

S12A9
Solute carrier family 12 member 9

1

0

High-throughput

0.232

Low

634198

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025