Protein: SPR2E
Small proline-rich protein 2E (SPR-2E) (Small proline-rich protein II) (SPR-II)

Gene: SPR2E, SPRR2E
Organism: Homo sapiens
Interactions: 29
UniProt ID: P22531

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0005198 - structural molecule activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008544 - epidermis development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

66481

RASFA
Ras association domain-containing protein 10

1

1

High-throughput

0.536

High

296872

RASF9
Ras association domain-containing protein 9

1

1

High-throughput

0.536

High

649761

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

649765

RASF2
Ras association domain-containing protein 2

1

0

High-throughput

0.513

High

649767

TP53B
TP53-binding protein 1

1

0

High-throughput

0.513

High

649777

WRP73
WD repeat-containing protein WRAP73

1

0

High-throughput

0.513

High

66686

ARI3C
AT-rich interactive domain-containing protein 3C

1

0

High-throughput

0.493

High

649766

CBX1
Chromobox protein homolog 1

1

1

High-throughput

0.489

High

649762

RYK
Tyrosine-protein kinase RYK

1

0

High-throughput

0.479

High

424136

S10A8
Protein S100-A8

1

1

High-throughput

0.479

High

444901

S10A9
Protein S100-A9

1

1

High-throughput

0.479

High

623099

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

649768

PTK6
Protein-tyrosine kinase 6

1

3

High-throughput

0.479

High

456611

ANXA2
Annexin A2

1

0

High-throughput

0.458

High

649760

CASPE
Caspase-14

1

0

High-throughput

0.458

High

649763

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

0

High-throughput

0.458

High

649764

KC1E
Casein kinase I isoform epsilon

1

0

High-throughput

0.458

High

649772

GSDMA
Gasdermin-A

1

0

High-throughput

0.458

High

649774

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.458

High

649770

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.445

High

649771

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

282668

E2F6
Transcription factor E2F6

1

0

High-throughput

0.279

Low

649775

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

0

High-throughput

0.279

Low

649769

DDR2
Discoidin domain-containing receptor 2

1

0

High-throughput

0.261

Low

649759

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.249

Low

649773

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

649776

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

649778

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

0

Small-scale

0.249

Low

649779

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025