Protein: WDR54
WD repeat-containing protein 54

Gene: WDR54
Organism: Homo sapiens
Interactions: 53
UniProt ID: Q9H977

Gene Ontology (top 5):
GO:0002091 - negative regulation of receptor internalization
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0007338 - single fertilization
GO:0007342 - fusion of sperm to egg plasma membrane involved in single fertilization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1272297

DOK3
Docking protein 3

3

0

High-throughput

0.638

High

1358055

OSCP1
Protein OSCP1

3

0

High-throughput

0.638

High

192024

GLYG2
Glycogenin-2

2

0

High-throughput

0.602

High

547483

DMD
Dystrophin

2

0

High-throughput

0.602

High

712280

TKT
Transketolase

2

0

High-throughput

0.602

High

1436846

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

2

0

High-throughput

0.602

High

1436850

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

2

0

High-throughput

0.602

High

1436851

GMEB1
Glucocorticoid modulatory element-binding protein 1

2

0

High-throughput

0.602

High

1196912

BCL7A
B-cell CLL/lymphoma 7 protein family member A

2

1

High-throughput

0.574

High

1357472

BCL7C
B-cell CLL/lymphoma 7 protein family member C

2

1

High-throughput

0.574

High

253455

CST8
Cystatin-8

1

0

High-throughput

0.513

High

299790

MPDZ
Multiple PDZ domain protein

1

0

High-throughput

0.513

High

1371537

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

0

High-throughput

0.513

High

1416416

BOC
Brother of CDO

1

0

High-throughput

0.513

High

1436845

CAH14
Carbonic anhydrase 14

1

0

High-throughput

0.513

High

1436847

TRAK1
Trafficking kinesin-binding protein 1

1

0

High-throughput

0.513

High

1208335

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

1

1

High-throughput

0.489

High

508648

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

173380

XPO1
Exportin-1

1

1

High-throughput

0.479

High

1030942

TSPY1
Testis-specific Y-encoded protein 1

1

1

High-throughput

0.479

High

1372082

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.460

High

242956

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

1098210

DUS8
Dual specificity protein phosphatase 8

1

0

High-throughput

0.458

High

1255579

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1436842

WDR54
WD repeat-containing protein 54

1

0

Small-scale

0.458

High

511002

TSPY3
Testis-specific Y-encoded protein 3

1

1

High-throughput

0.445

High

635387

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

0

High-throughput

0.426

High

1405861

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.426

High

1208281

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

1

High-throughput

0.407

High

1436848

MEMO1
Protein MEMO1

4

0

High-throughput

0.362

High

1386164

FWCH2
FLYWCH family member 2

3

0

High-throughput

0.347

High

1398115

STAC3
SH3 and cysteine-rich domain-containing protein 3

3

0

High-throughput

0.347

High

351728

SG1D1
Secretoglobin family 1D member 1

2

0

High-throughput

0.328

High

1436843

APEX2
DNA-(apurinic or apyrimidinic site) endonuclease 2

2

0

High-throughput

0.328

High

1411585

NUD22
Uridine diphosphate glucose pyrophosphatase NUDT22

2

0

High-throughput

0.316

High

286588

SG2A1
Mammaglobin-B

1

0

High-throughput

0.279

Low

288202

CLC3A
C-type lectin domain family 3 member A

1

0

High-throughput

0.279

Low

1248894

LCN15
Lipocalin-15

1

0

High-throughput

0.279

Low

1253047

ACP7
Acid phosphatase type 7

1

0

High-throughput

0.279

Low

1326742

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.279

Low

1329154

DB125
Beta-defensin 125

1

0

High-throughput

0.279

Low

1335516

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

1

0

High-throughput

0.279

Low

1390563

BORC8
BLOC-1-related complex subunit 8

1

0

High-throughput

0.279

Low

1400304

CC85A
Coiled-coil domain-containing protein 85A

1

0

High-throughput

0.279

Low

1409890

RETNB
Resistin-like beta

1

0

High-throughput

0.279

Low

1431095

GTSFL
Gametocyte-specific factor 1-like

1

0

High-throughput

0.279

Low

1432146

IKZF4
Zinc finger protein Eos

1

0

High-throughput

0.279

Low

1433174

OFUT1
GDP-fucose protein O-fucosyltransferase 1

1

0

High-throughput

0.279

Low

1436844

NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

1

0

High-throughput

0.279

Low

1436849

CCDC9
Coiled-coil domain-containing protein 9

1

0

High-throughput

0.279

Low

1115440

CUL4B
Cullin-4B

1

0

High-throughput

0.249

Low

1103885

PM2P3
Putative postmeiotic segregation increased 2-like protein 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025