Protein: PEX5
Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)

Gene: PEX5
Organism: Homo sapiens
Interactions: 191
UniProt ID: P50542

Gene Ontology (top 5):
GO:0000038 - very long-chain fatty acid metabolic process
GO:0000268 - peroxisome targeting sequence binding
GO:0000425 - pexophagy
GO:0001764 - neuron migration
GO:0005052 - peroxisome matrix targeting signal-1 binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

134773

PEX7
Peroxisomal targeting signal 2 receptor

5

16

Small-scale

0.927

High

261973

PEX14
Peroxisomal membrane protein PEX14

11

5

Small-scale

0.760

High

134610

PEX12
Peroxisome assembly protein 12

6

3

Small-scale

0.738

High

840292

PEX13
Peroxisomal membrane protein PEX13

5

3

Small-scale

0.711

High

840254

ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

4

6

Small-scale

0.671

High

840313

PECR
Peroxisomal trans-2-enoyl-CoA reductase

4

2

Small-scale

0.671

High

373362

CATA
Catalase

4

2

Small-scale

0.670

High

840242

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

4

4

Small-scale

0.670

High

153222

ACOT8
Acyl-coenzyme A thioesterase 8

4

0

Small-scale

0.663

High

238604

PEX10
Peroxisome biogenesis factor 10

3

4

Small-scale

0.646

High

116557

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

3

2

Small-scale

0.640

High

840297

AP2M1
AP-2 complex subunit mu

3

0

High-throughput

0.638

High

840351

NEUR2
Sialidase-2

3

0

High-throughput

0.638

High

267385

ECI2
Enoyl-CoA delta isomerase 2

3

6

Small-scale

0.631

High

793671

CACP
Carnitine O-acetyltransferase

3

4

Small-scale

0.631

High

840238

DHB4
Peroxisomal multifunctional enzyme type 2

3

5

Small-scale

0.631

High

840280

LONP2
Lon protease homolog 2, peroxisomal

3

4

Small-scale

0.631

High

840312

DHRS4
Dehydrogenase/reductase SDR family member 4

3

2

Small-scale

0.631

High

840327

DECR2
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

3

3

Small-scale

0.631

High

840332

TBA8
Tubulin alpha-8 chain

3

7

Small-scale

0.631

High

599292

AGT1
Alanine--glyoxylate aminotransferase

2

1

Small-scale

0.629

High

840244

ATM
Serine-protein kinase ATM

2

1

Small-scale

0.618

High

840251

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

9

High-throughput

0.618

High

840264

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.618

High

840281

MIRO2
Mitochondrial Rho GTPase 2

1

8

High-throughput

0.618

High

447736

THIK
3-ketoacyl-CoA thiolase, peroxisomal

2

2

High-throughput

0.611

High

682728

HNRH1
Heterogeneous nuclear ribonucleoprotein H

2

9

High-throughput

0.606

High

840293

GLMN
Glomulin

2

1

High-throughput

0.606

High

172571

GNPAT
Dihydroxyacetone phosphate acyltransferase

3

0

Small-scale

0.604

High

840341

HACL1
2-hydroxyacyl-CoA lyase 1

3

0

Small-scale

0.604

High

840347

GSTK1
Glutathione S-transferase kappa 1

3

0

Small-scale

0.604

High

840317

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.602

High

217994

PEX1
Peroxisomal ATPase PEX1

2

4

Small-scale

0.595

High

657902

PEX2
Peroxisome biogenesis factor 2

2

1

Small-scale

0.584

High

835590

GSK3B
Glycogen synthase kinase-3 beta

2

6

High-throughput

0.584

High

840260

TYSD1
Peroxisomal leader peptide-processing protease

2

1

Small-scale

0.584

High

840272

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

2

7

Small-scale

0.584

High

840275

ACD11
Acyl-CoA dehydrogenase family member 11

2

1

Small-scale

0.584

High

840322

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

2

0

High-throughput

0.580

High

301682

TRI37
E3 ubiquitin-protein ligase TRIM37

1

11

Small-scale

0.573

High

416593

S10A6
Protein S100-A6

1

3

High-throughput

0.573

High

421997

LDHB
L-lactate dehydrogenase B chain

1

3

High-throughput

0.573

High

840266

CAPR2
Caprin-2

1

1

High-throughput

0.573

High

840305

OXDD
D-aspartate oxidase

2

2

Small-scale

0.571

High

840284

PTGR3
Prostaglandin reductase 3

2

0

Small-scale

0.559

High

840299

SCRN2
Secernin-2

2

1

High-throughput

0.553

High

840261

CCD14
Coiled-coil domain-containing protein 14

1

0

High-throughput

0.549

High

840335

PRR13
Proline-rich protein 13

1

0

High-throughput

0.549

High

840278

NUFP2
FMR1-interacting protein NUFIP2

1

1

High-throughput

0.541

High

840326

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

1

High-throughput

0.541

High

840348

FIS1
Mitochondrial fission 1 protein

2

0

Small-scale

0.539

High

64051

AQ12B
Aquaporin-12B

1

1

High-throughput

0.536

High

318938

CEP43
Centrosomal protein 43

1

1

High-throughput

0.536

High

673043

CCND2
G1/S-specific cyclin-D2

1

6

High-throughput

0.536

High

724716

MYH9
Myosin-9

1

1

High-throughput

0.536

High

840253

MD2BP
MAD2L1-binding protein

1

1

High-throughput

0.536

High

840258

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.536

High

840300

CREL1
Protein disulfide isomerase CRELD1

1

4

High-throughput

0.536

High

840314

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.536

High

840352

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

2

High-throughput

0.536

High

840245

SQSTM
Sequestosome-1

1

4

Small-scale

0.534

High

840268

ACD10
Acyl-CoA dehydrogenase family member 10

1

2

Small-scale

0.527

High

840265

ZN772
Zinc finger protein 772

1

1

High-throughput

0.523

High

305066

SPN1
Snurportin-1

1

0

High-throughput

0.518

High

840255

PLEC
Plectin

1

1

High-throughput

0.515

High

156664

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

High-throughput

0.513

High

245671

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

677904

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.513

High

782877

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.513

High

837116

ENTP1
Ectonucleoside triphosphate diphosphohydrolase 1

1

0

High-throughput

0.513

High

840239

CACB3
Voltage-dependent L-type calcium channel subunit beta-3

1

0

High-throughput

0.513

High

840270

TM154
Transmembrane protein 154

1

0

High-throughput

0.513

High

840288

SYTL5
Synaptotagmin-like protein 5

1

0

High-throughput

0.513

High

840320

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.513

High

840350

FBX7
F-box only protein 7

1

0

High-throughput

0.513

High

271054

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

2

Small-scale

0.501

High

840248

PEX6
Peroxisomal ATPase PEX6

1

4

Small-scale

0.501

High

840294

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

4

Small-scale

0.501

High

678836

HXA7
Homeobox protein Hox-A7

1

3

High-throughput

0.494

High

840262

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

6

High-throughput

0.494

High

237878

AP180
Clathrin coat assembly protein AP180

1

7

High-throughput

0.489

High

239858

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

7

High-throughput

0.489

High

312786

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

9

High-throughput

0.489

High

351148

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

2

High-throughput

0.489

High

796058

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.489

High

840252

HLX
H2.0-like homeobox protein

1

8

High-throughput

0.489

High

840282

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

3

High-throughput

0.489

High

840298

ERLEC
Endoplasmic reticulum lectin 1

1

1

High-throughput

0.489

High

840302

RN145
RING finger protein 145

1

2

High-throughput

0.489

High

840308

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.489

High

840323

C1QR1
Complement component C1q receptor

1

1

High-throughput

0.489

High

329096

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.486

High

749238

BRCA1
Breast cancer type 1 susceptibility protein

1

7

High-throughput

0.481

High

840237

RL14
Large ribosomal subunit protein eL14

1

2

High-throughput

0.481

High

840337

TOM7
Mitochondrial import receptor subunit TOM7 homolog

1

1

High-throughput

0.481

High

840277

PEX26
Peroxisome assembly protein 26

1

0

Small-scale

0.480

High

59141

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

162520

XPO1
Exportin-1

1

9

High-throughput

0.479

High

170303

TIF1A
Transcription intermediary factor 1-alpha

1

10

Small-scale

0.479

High

409031

K2C8
Keratin, type II cytoskeletal 8

1

5

High-throughput

0.479

High

552249

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

573617

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

2

High-throughput

0.479

High

632218

TNR6
Tumor necrosis factor receptor superfamily member 6

1

1

High-throughput

0.479

High

823355

PAXI
Paxillin

1

1

High-throughput

0.479

High

835285

GSK3A
Glycogen synthase kinase-3 alpha

1

6

High-throughput

0.479

High

840241

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.479

High

840247

DCTN2
Dynactin subunit 2

1

1

High-throughput

0.479

High

840249

CUL3
Cullin-3

1

5

High-throughput

0.479

High

840256

KS6A2
Ribosomal protein S6 kinase alpha-2

1

3

High-throughput

0.479

High

840257

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

1

High-throughput

0.479

High

840263

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

1

High-throughput

0.479

High

840273

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

840279

MAVS
Mitochondrial antiviral-signaling protein

1

7

High-throughput

0.479

High

840290

CNOT9
CCR4-NOT transcription complex subunit 9

1

1

High-throughput

0.479

High

840291

GOGA1
Golgin subfamily A member 1

1

2

High-throughput

0.479

High

840303

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.479

High

840306

NECD
Necdin

1

2

High-throughput

0.479

High

840318

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

840324

PXMP2
Peroxisomal membrane protein 2

1

2

High-throughput

0.479

High

840336

MTCH1
Mitochondrial carrier homolog 1

1

2

High-throughput

0.479

High

840339

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

840342

HOOK1
Protein Hook homolog 1

1

2

High-throughput

0.479

High

840353

MTCH2
Mitochondrial carrier homolog 2

1

2

High-throughput

0.479

High

66473

A8K3Q9
Large ribosomal subunit protein eL14

1

2

High-throughput

0.470

High

840267

Q6IPH7
Large ribosomal subunit protein eL14

1

2

High-throughput

0.470

High

840269

Q6NSB6
MKRN3 protein

1

1

High-throughput

0.470

High

840276

Q75MR5
Mitochondrial import receptor subunit TOM7 homolog

1

1

High-throughput

0.470

High

840285

Q8N5N8
TM6SF1 protein

1

1

High-throughput

0.470

High

157549

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.458

High

734497

ARL3
ADP-ribosylation factor-like protein 3

1

0

High-throughput

0.458

High

840236

VASP
Vasodilator-stimulated phosphoprotein

1

0

High-throughput

0.458

High

840240

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

840301

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

840319

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

840325

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.458

High

840329

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

840330

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

840331

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

840349

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

840246

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

7

High-throughput

0.445

High

840283

SLX4
Structure-specific endonuclease subunit SLX4

1

10

High-throughput

0.445

High

840316

ZDHC5
Palmitoyltransferase ZDHHC5

1

4

High-throughput

0.445

High

840243

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

1

1

High-throughput

0.439

High

840315

TM6S1
Transmembrane 6 superfamily member 1

1

1

High-throughput

0.439

High

840345

ANR50
Ankyrin repeat domain-containing protein 50

1

3

High-throughput

0.439

High

650692

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

719988

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

840346

TRI33
E3 ubiquitin-protein ligase TRIM33

1

10

High-throughput

0.437

High

3459

A0A0S2Z6F4
Ankyrin repeat domain 50 isoform 2

1

5

High-throughput

0.417

High

68551

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

1

Small-scale

0.408

High

161508

S27A2
Long-chain fatty acid transport protein 2

1

2

Small-scale

0.408

High

173378

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

1

6

Small-scale

0.408

High

539787

IDE
Insulin-degrading enzyme

1

2

Small-scale

0.408

High

541963

OXDA
D-amino-acid oxidase

1

2

Small-scale

0.408

High

606957

SCP2
Sterol carrier protein 2

1

8

Small-scale

0.408

High

713756

HYES
Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2

1

2

Small-scale

0.408

High

729211

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

2

Small-scale

0.408

High

761645

MPV17
Protein Mpv17

1

2

Small-scale

0.408

High

833056

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

2

Small-scale

0.408

High

840250

BAAT
Bile acid-CoA:amino acid N-acyltransferase

1

2

Small-scale

0.408

High

840271

PAOX
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

1

3

Small-scale

0.408

High

840286

ACOT4
Peroxisomal succinyl-coenzyme A thioesterase

1

2

Small-scale

0.408

High

840304

ACOX2
Peroxisomal acyl-coenzyme A oxidase 2

1

6

Small-scale

0.408

High

840333

HAOX2
2-Hydroxyacid oxidase 2

1

3

Small-scale

0.408

High

840343

HAOX1
2-Hydroxyacid oxidase 1

1

3

Small-scale

0.408

High

840344

OCTC
Peroxisomal carnitine O-octanoyltransferase

1

4

Small-scale

0.408

High

484507

ECE2
Endothelin-converting enzyme 2

1

1

High-throughput

0.407

High

276643

IDHC
Isocitrate dehydrogenase [NADP] cytoplasmic

1

0

Small-scale

0.391

High

324917

DCMC
Malonyl-CoA decarboxylase, mitochondrial

1

0

Small-scale

0.391

High

469738

NUDT7
Peroxisomal coenzyme A diphosphatase NUDT7

1

0

Small-scale

0.391

High

670819

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

Small-scale

0.391

High

718458

NOS2
Nitric oxide synthase, inducible

1

0

Small-scale

0.391

High

840338

SOX
Peroxisomal sarcosine oxidase

1

0

Small-scale

0.391

High

840340

AMACR
Alpha-methylacyl-CoA racemase

1

0

Small-scale

0.391

High

429307

SAP
Prosaposin

2

0

High-throughput

0.316

High

840321

ZFAN3
AN1-type zinc finger protein 3

2

0

High-throughput

0.316

High

840289

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

0

High-throughput

0.299

High

840311

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.296

High

840295

ACD
Adrenocortical dysplasia protein homolog

1

0

High-throughput

0.282

High

840328

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.282

High

245192

RAMP1
Receptor activity-modifying protein 1

1

0

High-throughput

0.279

Low

352923

IFNG
Interferon gamma

1

0

High-throughput

0.279

Low

840259

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

840274

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.279

Low

840287

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.279

Low

840296

FAM3D
Protein FAM3D

1

0

High-throughput

0.279

Low

840307

CGRE1
Cell growth regulator with EF hand domain protein 1

1

0

High-throughput

0.279

Low

840309

SSX3
Protein SSX3

1

0

High-throughput

0.279

Low

840310

KXDL1
KxDL motif-containing protein 1

1

0

High-throughput

0.279

Low

840334

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.279

Low

722922

SSR5
Somatostatin receptor type 5

1

0

Small-scale

0.264

Low


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Last updated: 15 Jul 2024