Protein: LYPD3
Ly6/PLAUR domain-containing protein 3 (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4)

Gene: LYPD3
Organism: Homo sapiens
Interactions: 142
UniProt ID: O95274

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0007160 - cell-matrix adhesion
GO:0034392 - negative regulation of smooth muscle cell apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

178694

SCAM1
Secretory carrier-associated membrane protein 1

4

1

High-throughput

0.691

High

332618

AT2B4
Plasma membrane calcium-transporting ATPase 4

3

1

High-throughput

0.667

High

332622

MTOR
Serine/threonine-protein kinase mTOR

3

1

High-throughput

0.667

High

332629

CKAP4
Cytoskeleton-associated protein 4

3

1

High-throughput

0.667

High

332645

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

3

1

High-throughput

0.667

High

321992

ENDD1
Endonuclease domain-containing 1 protein

4

0

High-throughput

0.661

High

270870

CLAP2
CLIP-associating protein 2

3

2

High-throughput

0.656

High

332617

SL9A1
Sodium/hydrogen exchanger 1

3

0

High-throughput

0.638

High

332626

ARFP2
Arfaptin-2

3

0

High-throughput

0.638

High

332639

SLMAP
Sarcolemmal membrane-associated protein

3

0

High-throughput

0.638

High

332657

NCEH1
Neutral cholesterol ester hydrolase 1

3

0

High-throughput

0.638

High

332667

LAP4B
Lysosomal-associated transmembrane protein 4B

3

0

High-throughput

0.638

High

332670

C2CD5
C2 domain-containing protein 5

3

0

High-throughput

0.638

High

332672

S41A1
Solute carrier family 41 member 1

3

0

High-throughput

0.638

High

332682

LMBR1
Limb region 1 protein homolog

3

0

High-throughput

0.638

High

332683

CTL1
Choline transporter-like protein 1

3

0

High-throughput

0.638

High

332685

LPAR1
Lysophosphatidic acid receptor 1

3

0

High-throughput

0.638

High

332688

SYMPK
Symplekin

3

0

High-throughput

0.638

High

332696

XPO6
Exportin-6

3

0

High-throughput

0.638

High

332706

PIGU
GPI-anchor transamidase component PIGU

3

0

High-throughput

0.638

High

332716

COMD9
COMM domain-containing protein 9

3

0

High-throughput

0.638

High

332722

DYN3
Dynamin-3

3

0

High-throughput

0.638

High

332726

FLVC1
Choline/ethanolamine transporter FLVCR1

3

0

High-throughput

0.638

High

332666

GLT10
Polypeptide N-acetylgalactosaminyltransferase 10

4

1

High-throughput

0.630

High

332674

PHTF2
Protein PHTF2

4

1

High-throughput

0.630

High

133155

QSOX1
Sulfhydryl oxidase 1

2

1

High-throughput

0.611

High

332624

CLCN3
H(+)/Cl(-) exchange transporter 3

2

1

High-throughput

0.611

High

332619

COT2
COUP transcription factor 2

3

1

High-throughput

0.609

High

332625

CLCN7
H(+)/Cl(-) exchange transporter 7

3

1

High-throughput

0.609

High

332636

ATR
Serine/threonine-protein kinase ATR

3

1

High-throughput

0.609

High

332647

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

3

1

High-throughput

0.609

High

332690

FAKD4
FAST kinase domain-containing protein 4

3

2

High-throughput

0.609

High

332713

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

3

1

High-throughput

0.609

High

332718

XPO7
Exportin-7

3

2

High-throughput

0.609

High

332721

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

3

2

High-throughput

0.609

High

332725

TNPO3
Transportin-3

3

2

High-throughput

0.609

High

332729

5MP1
eIF5-mimic protein 1

3

1

High-throughput

0.609

High

164499

TNPO2
Transportin-2

3

1

High-throughput

0.599

High

332616

PTN1
Tyrosine-protein phosphatase non-receptor type 1

3

1

High-throughput

0.593

High

271646

HIP1R
Huntingtin-interacting protein 1-related protein

2

0

High-throughput

0.585

High

332609

AGR2
Anterior gradient protein 2 homolog

2

1

Small-scale

0.584

High

332651

ECM29
Proteasome adapter and scaffold protein ECM29

2

3

High-throughput

0.558

High

332715

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

2

2

High-throughput

0.558

High

332614

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

3

High-throughput

0.541

High

332631

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

1

High-throughput

0.541

High

332608

BAG4
BAG family molecular chaperone regulator 4

1

0

High-throughput

0.518

High

332615

IGF1R
Insulin-like growth factor 1 receptor

1

0

High-throughput

0.518

High

332620

LSP1
Lymphocyte-specific protein 1

1

0

High-throughput

0.518

High

332633

MSLN
Mesothelin

1

0

High-throughput

0.513

High

332662

TMC4
Voltage-gated chloride channel TMC4

1

0

High-throughput

0.513

High

332698

CIB1
Calcium and integrin-binding protein 1

1

0

High-throughput

0.513

High

332703

T126A
Transmembrane protein 126A

1

0

High-throughput

0.513

High

165500

SCAM3
Secretory carrier-associated membrane protein 3

1

1

High-throughput

0.489

High

332627

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

1

High-throughput

0.489

High

332673

TEX14
Inactive serine/threonine-protein kinase TEX14

1

3

High-throughput

0.489

High

332719

PHTF1
Protein PHTF1

1

1

High-throughput

0.489

High

332637

CKAP5
Cytoskeleton-associated protein 5

1

2

High-throughput

0.479

High

332660

QSOX2
Sulfhydryl oxidase 2

1

1

High-throughput

0.479

High

332676

AT11C
Phospholipid-transporting ATPase IG

1

0

High-throughput

0.458

High

332681

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

0

High-throughput

0.458

High

332700

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.458

High

332679

AGR3
Anterior gradient protein 3

1

1

Small-scale

0.439

High

173637

BTAF1
TATA-binding protein-associated factor 172

1

1

High-throughput

0.437

High

330534

KI20A
Kinesin-like protein KIF20A

1

4

High-throughput

0.437

High

332610

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

1

High-throughput

0.437

High

332628

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.437

High

332642

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

332661

5MP2
eIF5-mimic protein 2

1

1

High-throughput

0.437

High

332687

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

332724

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

1

High-throughput

0.437

High

332623

S26A2
Sulfate transporter

1

0

High-throughput

0.426

High

332692

RSPRY
RING finger and SPRY domain-containing protein 1

1

0

High-throughput

0.426

High

95688

E3W994
Cytoplasmic linker associated protein 2

1

2

High-throughput

0.407

High

332648

Q4LE60
TNPO2 variant protein

1

1

High-throughput

0.407

High

332653

ASPH2
Aspartate beta-hydroxylase domain-containing protein 2

4

0

High-throughput

0.360

High

332654

MYORG
Myogenesis-regulating glycosidase

4

0

High-throughput

0.360

High

332655

TM214
Transmembrane protein 214

4

0

High-throughput

0.360

High

332704

TM245
Transmembrane protein 245

4

0

High-throughput

0.360

High

332705

GHITM
Growth hormone-inducible transmembrane protein

4

0

High-throughput

0.360

High

183114

GNPAT
Dihydroxyacetone phosphate acyltransferase

3

0

High-throughput

0.347

High

212526

GPAA1
GPI-anchor transamidase component GPAA1

3

0

High-throughput

0.347

High

228532

STRN
Striatin

3

0

High-throughput

0.347

High

230861

ORC5
Origin recognition complex subunit 5

3

0

High-throughput

0.347

High

332630

TMM94
Transmembrane protein 94

3

0

High-throughput

0.347

High

332632

TARB1
tRNA

3

0

High-throughput

0.347

High

332635

MTX1
Metaxin-1

3

0

High-throughput

0.347

High

332646

D19L1
Protein C-mannosyl-transferase DPY19L1

3

0

High-throughput

0.347

High

332649

MKS3
Meckelin

3

0

High-throughput

0.347

High

332664

UB2Q1
Ubiquitin-conjugating enzyme E2 Q1

3

0

High-throughput

0.347

High

332684

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

3

0

High-throughput

0.347

High

332691

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

3

0

High-throughput

0.347

High

332695

BOD1
Biorientation of chromosomes in cell division protein 1

3

0

High-throughput

0.347

High

332712

HELLS
Lymphoid-specific helicase

3

0

High-throughput

0.347

High

332714

CLDN1
Claudin domain-containing protein 1

3

0

High-throughput

0.347

High

332720

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

3

0

High-throughput

0.347

High

332723

PLAP
Phospholipase A-2-activating protein

3

0

High-throughput

0.347

High

332727

SPCS1
Signal peptidase complex subunit 1

3

0

High-throughput

0.347

High

332708

REEP1
Receptor expression-enhancing protein 1

2

0

High-throughput

0.328

High

155539

NEMP1
Nuclear envelope integral membrane protein 1

2

0

High-throughput

0.318

High

332656

TTI2
TELO2-interacting protein 2

2

0

High-throughput

0.318

High

332663

HEAT3
HEAT repeat-containing protein 3

2

0

High-throughput

0.318

High

332671

TPPC5
Trafficking protein particle complex subunit 5

2

0

High-throughput

0.318

High

332677

ZNT7
Zinc transporter 7

2

0

High-throughput

0.318

High

332686

GPI8
GPI-anchor transamidase

2

0

High-throughput

0.318

High

332697

PIGS
GPI-anchor transamidase component PIGS

2

0

High-throughput

0.318

High

332699

DCNL5
DCN1-like protein 5

2

0

High-throughput

0.318

High

332701

LNP
Endoplasmic reticulum junction formation protein lunapark

2

0

High-throughput

0.318

High

332702

ELOV4
Very long chain fatty acid elongase 4

2

0

High-throughput

0.318

High

332728

MTCH2
Mitochondrial carrier homolog 2

2

0

High-throughput

0.318

High

169868

AURKA
Aurora kinase A

1

0

High-throughput

0.282

High

186179

PPM1D
Protein phosphatase 1D

1

0

High-throughput

0.282

High

332612

CHK2
Serine/threonine-protein kinase Chk2

1

0

High-throughput

0.282

High

332634

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.282

High

332638

CASP8
Caspase-8

1

0

High-throughput

0.282

High

332644

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.282

High

332669

PALB2
Partner and localizer of BRCA2

1

0

High-throughput

0.282

High

332680

RBCC1
RB1-inducible coiled-coil protein 1

1

0

High-throughput

0.282

High

332709

BRMS1
Breast cancer metastasis-suppressor 1

1

0

High-throughput

0.282

High

332611

PX11B
Peroxisomal membrane protein 11B

1

0

High-throughput

0.279

Low

332613

MOS
Proto-oncogene serine/threonine-protein kinase mos

1

0

High-throughput

0.279

Low

332643

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

0

High-throughput

0.279

Low

332652

SE1L3
Protein sel-1 homolog 3

1

0

High-throughput

0.279

Low

332665

PCGF5
Polycomb group RING finger protein 5

1

0

High-throughput

0.279

Low

332675

DJC22
DnaJ homolog subfamily C member 22

1

0

High-throughput

0.279

Low

332689

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.279

Low

332694

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.279

Low

221704

TPPC3
Trafficking protein particle complex subunit 3

1

0

High-throughput

0.249

Low

240364

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.249

Low

301283

WFS1
Wolframin

1

0

High-throughput

0.249

Low

332621

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

1

0

High-throughput

0.249

Low

332640

CND1
Condensin complex subunit 1

1

0

High-throughput

0.249

Low

332650

RBM26
RNA-binding protein 26

1

0

High-throughput

0.249

Low

332658

BRAT1
Integrator complex assembly factor BRAT1

1

0

High-throughput

0.249

Low

332659

THADA
tRNA

1

0

High-throughput

0.249

Low

332668

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.249

Low

332678

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

0

High-throughput

0.249

Low

332693

RUSF1
RUS family member 1

1

0

High-throughput

0.249

Low

332707

ECT2
Protein ECT2

1

0

High-throughput

0.249

Low

332710

ANLN
Anillin

1

0

High-throughput

0.249

Low

332711

AAAS
Aladin

1

0

High-throughput

0.249

Low

332717

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.249

Low

332641

SNX17
Sorting nexin-17

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025