Protein: ASM
Sphingomyelin phosphodiesterase (EC 3.1.4.12) (EC 3.1.4.3) (Acid sphingomyelinase) (aSMase) [Cleaved into: Sphingomyelin phosphodiesterase, processed form]

Gene: ASM, SMPD1
Organism: Homo sapiens
Interactions: 30
UniProt ID: P17405

Gene Ontology (top 5):
GO:0001778 - plasma membrane repair
GO:0004767 - sphingomyelin phosphodiesterase activity
GO:0005615 - extracellular space
GO:0005764 - lysosome
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

604394

CALX
Calnexin

2

1

High-throughput

0.628

High

171397

S27A2
Long-chain fatty acid transport protein 2

2

0

High-throughput

0.585

High

604399

OS9
Protein OS-9

2

1

High-throughput

0.558

High

170653

CLGN
Calmegin

2

1

High-throughput

0.549

High

548409

MPRI
Cation-independent mannose-6-phosphate receptor

1

2

High-throughput

0.536

High

604397

CASP7
Caspase-7

1

1

Small-scale

0.536

High

244440

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

0

High-throughput

0.513

High

296341

ATRN
Attractin

1

0

High-throughput

0.513

High

593268

PGFRA
Platelet-derived growth factor receptor alpha

1

0

High-throughput

0.513

High

604398

SG2A2
Mammaglobin-A

1

0

High-throughput

0.513

High

604405

VTI1A
Vesicle transport through interaction with t-SNAREs homolog 1A

1

0

High-throughput

0.513

High

604410

T126A
Transmembrane protein 126A

1

0

High-throughput

0.513

High

483433

ANXA4
Annexin A4

1

1

High-throughput

0.508

High

604393

ANXA7
Annexin A7

1

1

High-throughput

0.508

High

604406

ERLEC
Endoplasmic reticulum lectin 1

1

1

High-throughput

0.489

High

604396

NR1H2
Oxysterols receptor LXR-beta

1

0

High-throughput

0.486

High

217803

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

604392

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

604402

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

604400

CASP8
Caspase-8

1

1

Small-scale

0.445

High

604411

SE1L1
Protein sel-1 homolog 1

2

0

High-throughput

0.328

High

604412

INSL5
Insulin-like peptide INSL5

2

0

High-throughput

0.328

High

604401

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

2

0

High-throughput

0.318

High

604403

FBX27
F-box only protein 27

1

0

High-throughput

0.279

Low

604404

GDAP1
Ganglioside-induced differentiation-associated protein 1

1

0

High-throughput

0.279

Low

604407

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.279

Low

604409

DUS23
Dual specificity protein phosphatase 23

1

0

High-throughput

0.265

Low

105282

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

604395

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.249

Low

604408

CNT3B
Contactin-associated protein-like 3B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025