Protein: MK
Midkine (MK) (Amphiregulin-associated protein) (ARAP) (Midgestation and kidney protein) (Neurite outgrowth-promoting factor 2) (Neurite outgrowth-promoting protein)

Gene: MK, MDK
Organism: Homo sapiens
Interactions: 83
UniProt ID: P21741

Gene Ontology (top 5):
GO:0001662 - behavioral fear response
GO:0002232 - leukocyte chemotaxis involved in inflammatory response
GO:0002286 - T cell activation involved in immune response
GO:0002690 - positive regulation of leukocyte chemotaxis
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

640574

AF9
Protein AF-9

2

1

High-throughput

0.628

High

640576

PTN9
Tyrosine-protein phosphatase non-receptor type 9

2

4

High-throughput

0.628

High

640584

H11
Histone H1.1

2

0

High-throughput

0.602

High

640626

CXXC1
CXXC-type zinc finger protein 1

2

0

High-throughput

0.602

High

400277

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

2

High-throughput

0.584

High

473367

HCK
Tyrosine-protein kinase HCK

2

0

High-throughput

0.580

High

640595

CHD9
Chromodomain-helicase-DNA-binding protein 9

2

1

High-throughput

0.574

High

640629

UBQL2
Ubiquilin-2

2

6

High-throughput

0.553

High

640632

UBQL1
Ubiquilin-1

2

6

High-throughput

0.553

High

640583

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.550

High

446644

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

598251

CL3L1
C-C motif chemokine 3-like 1

1

0

High-throughput

0.513

High

640586

NOTC2
Neurogenic locus notch homolog protein 2

1

0

High-throughput

0.513

High

640602

CAMKV
CaM kinase-like vesicle-associated protein

1

0

High-throughput

0.513

High

640625

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

0

High-throughput

0.513

High

287524

LRP6
Low-density lipoprotein receptor-related protein 6

1

5

Small-scale

0.501

High

640570

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

1

4

Small-scale

0.501

High

640592

LRP8
Low-density lipoprotein receptor-related protein 8

1

5

Small-scale

0.501

High

640630

ALK
ALK tyrosine kinase receptor

1

1

Small-scale

0.501

High

640624

UBQL4
Ubiquilin-4

1

6

High-throughput

0.494

High

640572

PSB10
Proteasome subunit beta type-10

1

1

High-throughput

0.489

High

640607

SORL
Sortilin-related receptor

1

4

High-throughput

0.489

High

640594

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.486

High

640580

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

371157

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

405786

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

572679

NID1
Nidogen-1

1

4

Small-scale

0.479

High

640591

NID2
Nidogen-2

1

4

Small-scale

0.479

High

640610

Q96AL5
PBX3 protein

1

1

High-throughput

0.470

High

271893

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

464808

SP1
Transcription factor Sp1

1

0

Small-scale

0.458

High

564797

NCAM1
Neural cell adhesion molecule 1

1

0

Small-scale

0.458

High

640578

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

640579

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

640582

ACTG
Actin, cytoplasmic 2

1

0

Small-scale

0.458

High

640597

TBA1A
Tubulin alpha-1A chain

1

0

Small-scale

0.458

High

640608

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

640616

TBB2B
Tubulin beta-2B chain

1

0

Small-scale

0.458

High

640627

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

640620

RN167
E3 ubiquitin-protein ligase RNF167

1

1

Small-scale

0.457

High

640573

PBX3
Pre-B-cell leukemia transcription factor 3

1

1

High-throughput

0.439

High

640587

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

5

Small-scale

0.437

High

640589

LG3BP
Galectin-3-binding protein

1

0

High-throughput

0.426

High

640598

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.426

High

175836

SET1A
Histone-lysine N-methyltransferase SETD1A

2

0

High-throughput

0.328

High

190118

TNC18
Trinucleotide repeat-containing gene 18 protein

2

0

High-throughput

0.328

High

269740

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

2

0

High-throughput

0.328

High

604595

UBF1
Nucleolar transcription factor 1

2

0

High-throughput

0.328

High

640571

BRD2
Bromodomain-containing protein 2

2

0

High-throughput

0.328

High

640577

CLK2
Dual specificity protein kinase CLK2

2

0

High-throughput

0.328

High

640581

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

0

High-throughput

0.328

High

640590

PPIG
Peptidyl-prolyl cis-trans isomerase G

2

0

High-throughput

0.328

High

640603

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

2

0

High-throughput

0.328

High

640605

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

0

High-throughput

0.328

High

640612

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

2

0

High-throughput

0.328

High

640615

RPP25
Ribonuclease P protein subunit p25

2

0

High-throughput

0.328

High

640619

PININ
Pinin

2

0

High-throughput

0.328

High

640621

CWC22
Pre-mRNA-splicing factor CWC22 homolog

2

0

High-throughput

0.328

High

640622

E41L5
Band 4.1-like protein 5

2

0

High-throughput

0.328

High

640628

AFF4
AF4/FMR2 family member 4

2

0

High-throughput

0.328

High

640633

SRRM2
Serine/arginine repetitive matrix protein 2

2

0

High-throughput

0.328

High

640609

RL36L
Ribosomal protein eL42-like

2

0

High-throughput

0.318

High

640618

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

0

High-throughput

0.318

High

640593

TCEA2
Transcription elongation factor A protein 2

2

0

High-throughput

0.316

High

640596

TMED8
Protein TMED8

2

0

High-throughput

0.316

High

640600

RBFA
Putative ribosome-binding factor A, mitochondrial

2

0

High-throughput

0.316

High

640604

JOS2
Josephin-2

2

0

High-throughput

0.316

High

640611

MID49
Mitochondrial dynamics protein MID49

2

0

High-throughput

0.316

High

640617

AP1M1
AP-1 complex subunit mu-1

2

0

High-throughput

0.316

High

640631

NFU1
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

2

0

High-throughput

0.316

High

180479

PLS1
Phospholipid scramblase 1

1

0

Small-scale

0.292

High

640585

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.282

High

640575

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.279

Low

640601

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.279

Low

640614

SIN3A
Paired amphipathic helix protein Sin3a

1

0

High-throughput

0.279

Low

640623

ZCC17
Zinc finger CCHC domain-containing protein 17

1

0

High-throughput

0.279

Low

620130

NUCL
Nucleolin

1

0

Small-scale

0.261

Low

640634

FBX7
F-box only protein 7

1

0

High-throughput

0.261

Low

275869

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

0

Small-scale

0.249

Low

640599

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.249

Low

640606

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.249

Low

640588

S20A2
Sodium-dependent phosphate transporter 2

1

0

High-throughput

0.232

Low

640613

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025