Protein: SEM1
26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) (Deleted in split hand/split foot protein 1) (Split hand/foot deleted protein 1) (Split hand/foot malformation type 1 protein)

Gene: SEM1
Organism: Homo sapiens
Interactions: 173
UniProt ID: P60896

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0000724 - double-strand break repair via homologous recombination
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006406 - mRNA export from nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

210907

PSMD3
26S proteasome non-ATPase regulatory subunit 3

7

2

Small-scale

0.964

High

904269

BRCA2
Breast cancer type 2 susceptibility protein

11

0

Small-scale

0.929

High

127915

PSD11
26S proteasome non-ATPase regulatory subunit 11

6

2

Small-scale

0.928

High

954692

PSMD6
26S proteasome non-ATPase regulatory subunit 6

4

1

Small-scale

0.887

High

954697

PCID2
PCI domain-containing protein 2

7

4

Small-scale

0.862

High

954762

PSD13
26S proteasome non-ATPase regulatory subunit 13

4

0

Small-scale

0.823

High

128191

PSD12
26S proteasome non-ATPase regulatory subunit 12

3

1

Small-scale

0.817

High

245684

GANP
Germinal-center associated nuclear protein

2

2

Small-scale

0.754

High

954730

LENG8
Leukocyte receptor cluster member 8

2

3

Small-scale

0.737

High

778645

PRS7
26S proteasome regulatory subunit 7

4

3

Small-scale

0.683

High

138043

PSDE
26S proteasome non-ATPase regulatory subunit 14

4

1

Small-scale

0.676

High

954668

PRS4
26S proteasome regulatory subunit 4

4

3

Small-scale

0.672

High

954682

PSMD2
26S proteasome non-ATPase regulatory subunit 2

4

2

Small-scale

0.672

High

507749

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

1

Small-scale

0.660

High

931636

RD23B
UV excision repair protein RAD23 homolog B

3

5

Small-scale

0.650

High

954693

UBE3C
Ubiquitin-protein ligase E3C

3

3

Small-scale

0.650

High

933597

PSMD4
26S proteasome non-ATPase regulatory subunit 4

4

0

Small-scale

0.643

High

929864

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

3

0

Small-scale

0.642

High

954732

PSMD1
26S proteasome non-ATPase regulatory subunit 1

3

2

Small-scale

0.640

High

954669

PRS8
26S proteasome regulatory subunit 8

3

4

Small-scale

0.633

High

954771

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

3

0

Small-scale

0.622

High

107441

F8WC89
SAC3 domain containing 1

1

2

Small-scale

0.618

High

931482

RD23A
UV excision repair protein RAD23 homolog A

2

6

Small-scale

0.611

High

954702

ECM29
Proteasome adapter and scaffold protein ECM29

2

1

Small-scale

0.611

High

954680

PSME1
Proteasome activator complex subunit 1

2

2

Small-scale

0.601

High

954755

UBQL2
Ubiquilin-2

2

5

Small-scale

0.601

High

295479

PSD10
26S proteasome non-ATPase regulatory subunit 10

3

0

Small-scale

0.597

High

954689

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

0

Small-scale

0.586

High

954733

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

Small-scale

0.586

High

954695

ADRM1
Proteasomal ubiquitin receptor ADRM1

2

0

Small-scale

0.585

High

610282

PRS6A
26S proteasome regulatory subunit 6A

2

7

Small-scale

0.584

High

906490

PSMD7
26S proteasome non-ATPase regulatory subunit 7

2

1

Small-scale

0.584

High

954670

PRS10
26S proteasome regulatory subunit 10B

2

4

Small-scale

0.584

High

954681

RAD51
DNA repair protein RAD51 homolog 1

2

0

Small-scale

0.577

High

954691

PSME4
Proteasome activator complex subunit 4

2

0

Small-scale

0.576

High

954736

PAAF1
Proteasomal ATPase-associated factor 1

2

0

Small-scale

0.576

High

954767

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

0

Small-scale

0.576

High

165302

PSA7
Proteasome subunit alpha type-7

2

3

Small-scale

0.571

High

633647

PSB1
Proteasome subunit beta type-1

2

3

Small-scale

0.571

High

681138

PSA2
Proteasome subunit alpha type-2

2

3

Small-scale

0.571

High

851279

PRS6B
26S proteasome regulatory subunit 6B

2

3

Small-scale

0.571

High

954700

INT11
Integrator complex subunit 11

2

1

Small-scale

0.571

High

954748

INT9
Integrator complex subunit 9

2

1

Small-scale

0.571

High

798915

BRCA1
Breast cancer type 1 susceptibility protein

2

0

Small-scale

0.561

High

874136

PSMD8
26S proteasome non-ATPase regulatory subunit 8

2

0

Small-scale

0.559

High

722927

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

Small-scale

0.547

High

954707

INT8
Integrator complex subunit 8

2

0

Small-scale

0.547

High

954729

INT4
Integrator complex subunit 4

2

0

Small-scale

0.547

High

954741

INT2
Integrator complex subunit 2

2

0

Small-scale

0.547

High

954749

INT7
Integrator complex subunit 7

2

0

Small-scale

0.547

High

954751

INT10
Integrator complex subunit 10

2

0

Small-scale

0.547

High

954757

INT6
Integrator complex subunit 6

2

0

Small-scale

0.547

High

325764

UBR5
E3 ubiquitin-protein ligase UBR5

1

3

Small-scale

0.536

High

543122

UBL4A
Ubiquitin-like protein 4A

1

2

Small-scale

0.536

High

856619

BAG6
Large proline-rich protein BAG6

1

4

Small-scale

0.536

High

875606

PRC2A
Protein PRRC2A

1

1

Small-scale

0.536

High

934361

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.536

High

954666

PSME3
Proteasome activator complex subunit 3

1

2

Small-scale

0.536

High

954678

UBE3A
Ubiquitin-protein ligase E3A

1

2

Small-scale

0.536

High

954684

CUL1
Cullin-1

1

2

Small-scale

0.536

High

954685

CUL2
Cullin-2

1

2

Small-scale

0.536

High

954686

CUL4B
Cullin-4B

1

2

Small-scale

0.536

High

954694

NEDD8
Ubiquitin-like protein NEDD8

1

1

Small-scale

0.536

High

954699

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

Small-scale

0.536

High

954717

UBP38
Ubiquitin carboxyl-terminal hydrolase 38

1

1

Small-scale

0.536

High

954720

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

1

Small-scale

0.536

High

954738

RN126
E3 ubiquitin-protein ligase RNF126

1

1

Small-scale

0.536

High

954745

UBQL4
Ubiquilin-4

1

6

Small-scale

0.536

High

954758

PSME2
Proteasome activator complex subunit 2

1

2

Small-scale

0.536

High

954760

UBQL1
Ubiquilin-1

1

5

Small-scale

0.536

High

954769

PRC2C
Protein PRRC2C

1

1

Small-scale

0.536

High

695081

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

Small-scale

0.527

High

128404

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

Small-scale

0.513

High

215283

TXNL1
Thioredoxin-like protein 1

1

0

Small-scale

0.513

High

246285

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

0

Small-scale

0.513

High

317820

LTN1
E3 ubiquitin-protein ligase listerin

1

0

Small-scale

0.513

High

337461

PSMG1
Proteasome assembly chaperone 1

1

0

Small-scale

0.513

High

346938

BAG2
BAG family molecular chaperone regulator 2

1

0

Small-scale

0.513

High

833589

UBA7
Ubiquitin-like modifier-activating enzyme 7

1

0

Small-scale

0.513

High

952427

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

0

Small-scale

0.513

High

954667

SUMO2
Small ubiquitin-related modifier 2

1

0

Small-scale

0.513

High

954673

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.513

High

954687

DX39B
Spliceosome RNA helicase DDX39B

1

0

Small-scale

0.513

High

954710

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

Small-scale

0.513

High

954713

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

Small-scale

0.513

High

954716

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

Small-scale

0.513

High

954719

ZFN2B
AN1-type zinc finger protein 2B

1

0

Small-scale

0.513

High

954723

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

Small-scale

0.513

High

954724

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.513

High

954725

PSMG2
Proteasome assembly chaperone 2

1

0

Small-scale

0.513

High

954735

BAG1
BAG family molecular chaperone regulator 1

1

0

Small-scale

0.513

High

954737

PSMG3
Proteasome assembly chaperone 3

1

0

Small-scale

0.513

High

954761

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

Small-scale

0.513

High

954763

NSF1C
NSFL1 cofactor p47

1

0

Small-scale

0.513

High

954765

POMP
Proteasome maturation protein

1

0

Small-scale

0.513

High

954766

FBX7
F-box only protein 7

1

0

Small-scale

0.513

High

954770

NUB1
NEDD8 ultimate buster 1

1

0

Small-scale

0.513

High

361189

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.493

High

767150

MERL
Merlin

1

0

High-throughput

0.493

High

774957

FUS
RNA-binding protein FUS

1

0

High-throughput

0.493

High

954675

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.493

High

954677

NC2B
Protein Dr1

1

0

High-throughput

0.493

High

954698

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.493

High

954772

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.493

High

954709

UBE3B
Ubiquitin-protein ligase E3B

1

2

Small-scale

0.489

High

954753

RN181
E3 ubiquitin-protein ligase RNF181

1

1

Small-scale

0.489

High

954759

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

Small-scale

0.489

High

228221

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.486

High

954740

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.486

High

847978

RAD52
DNA repair protein RAD52 homolog

1

0

Small-scale

0.480

High

700860

PSB4
Proteasome subunit beta type-4

1

5

Small-scale

0.479

High

954665

PSA6
Proteasome subunit alpha type-6

1

3

Small-scale

0.479

High

954674

EF1A1
Elongation factor 1-alpha 1

1

1

Small-scale

0.479

High

954676

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

Small-scale

0.479

High

954701

DDI2
Protein DDI1 homolog 2

1

5

Small-scale

0.479

High

954747

MDN1
Midasin

1

1

Small-scale

0.479

High

297536

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

Small-scale

0.458

High

347611

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

429620

JUN
Transcription factor Jun

1

0

High-throughput

0.458

High

536862

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

541917

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

565848

EF2
Elongation factor 2

1

0

Small-scale

0.458

High

675441

TYY1
Transcriptional repressor protein YY1

1

0

Small-scale

0.458

High

687945

EF1G
Elongation factor 1-gamma

1

0

Small-scale

0.458

High

814500

FEN1
Flap endonuclease 1

1

0

Small-scale

0.458

High

954683

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

0

Small-scale

0.458

High

954688

CKAP5
Cytoskeleton-associated protein 5

1

0

Small-scale

0.458

High

954696

TRXR1
Thioredoxin reductase 1, cytoplasmic

1

0

Small-scale

0.458

High

954705

TAF2
Transcription initiation factor TFIID subunit 2

1

0

Small-scale

0.458

High

954706

INT5
Integrator complex subunit 5

1

0

Small-scale

0.458

High

954708

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

Small-scale

0.458

High

954711

DDX42
ATP-dependent RNA helicase DDX42

1

0

Small-scale

0.458

High

954718

RB15B
Putative RNA-binding protein 15B

1

0

Small-scale

0.458

High

954722

PSMF1
Proteasome inhibitor PI31 subunit

1

0

Small-scale

0.458

High

954731

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.458

High

954734

ATX2
Ataxin-2

1

0

Small-scale

0.458

High

954743

RPF2
Ribosome production factor 2 homolog

1

0

Small-scale

0.458

High

954754

CCD39
Coiled-coil domain-containing protein 39

1

0

Small-scale

0.458

High

954756

NARF
Nuclear prelamin A recognition factor

1

0

Small-scale

0.458

High

954764

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

Small-scale

0.458

High

91850

C9JUP7
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.445

High

114594

H0YKT8
Proteasome subunit beta

1

3

High-throughput

0.445

High

700595

PSA5
Proteasome subunit alpha type-5

1

3

High-throughput

0.445

High

954679

EF1A2
Elongation factor 1-alpha 2

1

1

Small-scale

0.437

High

954768

TLN2
Talin-2

1

1

Small-scale

0.437

High

130419

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.426

High

192803

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.426

High

621609

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.426

High

667243

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.426

High

923483

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.426

High

954671

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.426

High

954672

SPT4H
Transcription elongation factor SPT4

1

0

High-throughput

0.426

High

954690

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.426

High

954714

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.426

High

954715

INT1
Integrator complex subunit 1

1

0

High-throughput

0.426

High

954726

INT12
Integrator complex subunit 12

1

0

High-throughput

0.426

High

954742

NELFA
Negative elongation factor A

1

0

High-throughput

0.426

High

954744

ENY2
Transcription and mRNA export factor ENY2

1

0

High-throughput

0.426

High

954746

SOSSC
SOSS complex subunit C

1

0

High-throughput

0.426

High

954750

INT13
Integrator complex subunit 13

1

0

High-throughput

0.426

High

954752

ARHGC
Rho guanine nucleotide exchange factor 12

1

0

High-throughput

0.426

High

697

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

2

High-throughput

0.407

High

97072

E9PMD8
Proteasome 26S subunit, ATPase 3

1

6

High-throughput

0.407

High

156530

UBFD1
Ubiquitin domain-containing protein UBFD1

1

0

Small-scale

0.279

Low

954703

OBI1
ORC ubiquitin ligase 1

1

0

Small-scale

0.279

Low

705296

GRN
Progranulin

1

0

High-throughput

0.268

Low

954704

Q6NUL7
Serine palmitoyltransferase 1

1

0

High-throughput

0.268

Low

954721

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

954712

DNAI3
Dynein axonemal intermediate chain 3

1

0

Small-scale

0.249

Low

954727

RBM33
RNA-binding protein 33

1

0

Small-scale

0.249

Low

954739

DYH6
Dynein axonemal heavy chain 6

1

0

Small-scale

0.249

Low

954728

Q96H21
HCG2012301

1

0

High-throughput

0.238

Low

67233

AN36A
Ankyrin repeat domain-containing protein 36A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025