Protein: SPT4H
Transcription elongation factor SPT4 (hSPT4) (DRB sensitivity-inducing factor 14 kDa subunit) (DSIF p14) (DRB sensitivity-inducing factor small subunit) (DSIF small subunit)

Gene: SPT4H, SUPT4H1
Organism: Homo sapiens
Interactions: 48
UniProt ID: P63272

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000993 - RNA polymerase II complex binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

130436

SPT5H
Transcription elongation factor SPT5

16

4

Small-scale

0.987

High

262509

MCE1
mRNA-capping enzyme

2

1

High-throughput

0.584

High

993462

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.536

High

690891

1433T
14-3-3 protein theta

1

3

High-throughput

0.536

High

923489

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

1

High-throughput

0.536

High

966183

1433G
14-3-3 protein gamma

1

3

High-throughput

0.536

High

993458

1433F
14-3-3 protein eta

1

3

High-throughput

0.536

High

993459

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.536

High

903123

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

0

High-throughput

0.518

High

993457

EWS
RNA-binding protein EWS

1

0

High-throughput

0.518

High

477989

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.513

High

480089

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

541937

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

725865

FGF9
Fibroblast growth factor 9

1

0

High-throughput

0.513

High

971393

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.513

High

973881

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

993461

FOXF2
Forkhead box protein F2

1

0

High-throughput

0.513

High

993465

PXK
PX domain-containing protein kinase-like protein

1

0

High-throughput

0.513

High

993469

RNF34
E3 ubiquitin-protein ligase RNF34

1

0

High-throughput

0.513

High

993471

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.513

High

993476

PAK5
Serine/threonine-protein kinase PAK 5

1

0

High-throughput

0.513

High

993479

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

1

High-throughput

0.489

High

993463

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.486

High

421892

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

131935

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

325781

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

Small-scale

0.479

High

946746

H2B1D
Histone H2B type 1-D

1

3

High-throughput

0.479

High

951958

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

1

High-throughput

0.479

High

993474

H2B1L
Histone H2B type 1-L

1

2

High-throughput

0.479

High

371714

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

970295

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

993460

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

993468

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

993470

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

993472

MCRS1
Microspherule protein 1

1

0

Small-scale

0.458

High

993473

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.458

High

993475

SP110
Sp110 nuclear body protein

1

0

High-throughput

0.458

High

330106

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.426

High

954672

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.426

High

993477

CPNE7
Copine-7

1

0

High-throughput

0.426

High

993466

CCD71
Coiled-coil domain-containing protein 71

1

0

High-throughput

0.279

Low

993467

DOK4
Docking protein 4

1

0

High-throughput

0.279

Low

155103

SOCS2
Suppressor of cytokine signaling 2

1

0

High-throughput

0.269

Low

123240

PDLI1
PDZ and LIM domain protein 1

1

0

High-throughput

0.265

Low

993478

NSG2
Neuronal vesicle trafficking-associated protein 2

1

0

High-throughput

0.265

Low

566624

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.249

Low

993464

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.249

Low

476131

ANXA5
Annexin A5

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025