Protein: RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4 (RNA polymerases I, II, and III subunit ABC4) (ABC10-alpha) (DNA-directed RNA polymerase II subunit K) (RNA polymerase II 7.0 kDa subunit) (RPB7.0) (RPB10alpha)

Gene: RPAB4, POLR2K
Organism: Homo sapiens
Interactions: 146
UniProt ID: P53803

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005665 - RNA polymerase II, core complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

339962

RPA1
DNA-directed RNA polymerase I subunit RPA1

4

9

Small-scale

0.895

High

667230

RPB1
DNA-directed RNA polymerase II subunit RPB1

4

9

Small-scale

0.890

High

923554

RPC2
DNA-directed RNA polymerase III subunit RPC2

4

6

Small-scale

0.881

High

621604

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

4

Small-scale

0.853

High

722920

RPB2
DNA-directed RNA polymerase II subunit RPB2

3

6

Small-scale

0.853

High

165026

RPC1
DNA-directed RNA polymerase III subunit RPC1

2

9

High-throughput

0.789

High

180259

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

4

High-throughput

0.789

High

923542

RPA2
DNA-directed RNA polymerase I subunit RPA2

2

6

High-throughput

0.789

High

912165

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

4

3

Small-scale

0.696

High

923493

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.691

High

923518

TF3B
Transcription factor IIIB 90 kDa subunit

1

3

High-throughput

0.691

High

621842

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

1

Small-scale

0.670

High

923553

RPC5
DNA-directed RNA polymerase III subunit RPC5

3

1

High-throughput

0.667

High

912037

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

3

1

Small-scale

0.660

High

923484

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

3

2

Small-scale

0.660

High

923486

RPB7
DNA-directed RNA polymerase II subunit RPB7

3

4

Small-scale

0.660

High

477962

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.656

High

615504

NELFE
Negative elongation factor E

1

0

High-throughput

0.656

High

774943

FUS
RNA-binding protein FUS

1

0

High-throughput

0.656

High

923497

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.656

High

192800

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

1

High-throughput

0.628

High

923525

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

2

4

High-throughput

0.628

High

48931

MED19
Mediator of RNA polymerase II transcription subunit 19

3

0

High-throughput

0.628

High

239558

MED14
Mediator of RNA polymerase II transcription subunit 14

2

3

High-throughput

0.611

High

287447

RPC9
DNA-directed RNA polymerase III subunit RPC9

2

1

High-throughput

0.611

High

430618

RPC4
DNA-directed RNA polymerase III subunit RPC4

2

1

High-throughput

0.611

High

787735

RPB9
DNA-directed RNA polymerase II subunit RPB9

2

5

High-throughput

0.611

High

923488

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

1

High-throughput

0.611

High

923512

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

1

High-throughput

0.611

High

923532

RPA49
DNA-directed RNA polymerase I subunit RPA49

2

1

High-throughput

0.611

High

923545

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

2

4

High-throughput

0.611

High

923569

RPC10
DNA-directed RNA polymerase III subunit RPC10

2

5

High-throughput

0.611

High

923572

RPC8
DNA-directed RNA polymerase III subunit RPC8

2

4

High-throughput

0.611

High

326314

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.586

High

190860

RPA34
DNA-directed RNA polymerase I subunit RPA34

2

0

High-throughput

0.585

High

316370

RMP
Unconventional prefoldin RPB5 interactor 1

2

0

High-throughput

0.585

High

923495

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

High-throughput

0.585

High

923509

SPT6H
Transcription elongation factor SPT6

2

0

High-throughput

0.585

High

923528

MED10
Mediator of RNA polymerase II transcription subunit 10

2

0

High-throughput

0.585

High

923538

RPAP3
RNA polymerase II-associated protein 3

2

0

High-throughput

0.585

High

923544

MED4
Mediator of RNA polymerase II transcription subunit 4

2

0

High-throughput

0.585

High

923561

UXT
Protein UXT

2

0

High-throughput

0.585

High

923519

SH3K1
SH3 domain-containing kinase-binding protein 1

2

0

High-throughput

0.580

High

64427

BDP1
Transcription factor TFIIIB component B'' homolog

1

1

High-throughput

0.536

High

130412

SPT5H
Transcription elongation factor SPT5

1

2

High-throughput

0.536

High

138660

IMA4
Importin subunit alpha-4

1

1

High-throughput

0.536

High

186367

RPC7
DNA-directed RNA polymerase III subunit RPC7

1

1

High-throughput

0.536

High

569079

T2FB
General transcription factor IIF subunit 2

1

2

High-throughput

0.536

High

625263

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.536

High

628734

TBP
TATA-box-binding protein

1

1

High-throughput

0.536

High

717734

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

1

High-throughput

0.536

High

718090

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

1

High-throughput

0.536

High

770361

T2FA
General transcription factor IIF subunit 1

1

1

High-throughput

0.536

High

910822

IMA1
Importin subunit alpha-1

1

1

High-throughput

0.536

High

923489

SPT4H
Transcription elongation factor SPT4

1

1

High-throughput

0.536

High

923491

CSK21
Casein kinase II subunit alpha

1

2

High-throughput

0.536

High

923498

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

1

High-throughput

0.536

High

923500

INT11
Integrator complex subunit 11

1

1

High-throughput

0.536

High

923506

BRWD3
Bromodomain and WD repeat-containing protein 3

1

1

High-throughput

0.536

High

923527

RPC7L
DNA-directed RNA polymerase III subunit RPC7-like

1

1

High-throughput

0.536

High

923529

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.536

High

923535

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

1

High-throughput

0.536

High

923543

GPN1
GPN-loop GTPase 1

1

5

High-throughput

0.536

High

923548

INT9
Integrator complex subunit 9

1

1

High-throughput

0.536

High

923565

INT6
Integrator complex subunit 6

1

1

High-throughput

0.536

High

923567

RUVB2
RuvB-like 2

1

1

High-throughput

0.536

High

923568

RUVB1
RuvB-like 1

1

1

High-throughput

0.536

High

923573

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.536

High

135905

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

0

High-throughput

0.513

High

335974

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

High-throughput

0.513

High

480065

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

541907

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

574185

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

908727

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.513

High

923485

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

923490

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

High-throughput

0.513

High

923494

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

923496

IMB1
Importin subunit beta-1

1

0

High-throughput

0.513

High

923502

INT3
Integrator complex subunit 3

1

0

High-throughput

0.513

High

923505

INT5
Integrator complex subunit 5

1

0

High-throughput

0.513

High

923508

INT8
Integrator complex subunit 8

1

0

High-throughput

0.513

High

923510

TRM1L
tRNA

1

0

High-throughput

0.513

High

923511

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.513

High

923513

INT1
Integrator complex subunit 1

1

0

High-throughput

0.513

High

923514

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

923515

ZN655
Zinc finger protein 655

1

0

High-throughput

0.513

High

923516

NELFB
Negative elongation factor B

1

0

High-throughput

0.513

High

923520

INT12
Integrator complex subunit 12

1

0

High-throughput

0.513

High

923522

INT4
Integrator complex subunit 4

1

0

High-throughput

0.513

High

923526

INT14
Integrator complex subunit 14

1

0

High-throughput

0.513

High

923530

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.513

High

923533

MAF1
Repressor of RNA polymerase III transcription MAF1 homolog

1

0

High-throughput

0.513

High

923534

INT2
Integrator complex subunit 2

1

0

High-throughput

0.513

High

923537

NELFA
Negative elongation factor A

1

0

High-throughput

0.513

High

923546

SOSSC
SOSS complex subunit C

1

0

High-throughput

0.513

High

923550

INT7
Integrator complex subunit 7

1

0

High-throughput

0.513

High

923551

INT13
Integrator complex subunit 13

1

0

High-throughput

0.513

High

923552

INT10
Integrator complex subunit 10

1

0

High-throughput

0.513

High

923555

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.513

High

923558

MED29
Mediator of RNA polymerase II transcription subunit 29

1

0

High-throughput

0.513

High

923563

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.513

High

923566

TTF2
Transcription termination factor 2

1

0

High-throughput

0.513

High

923570

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.513

High

923499

INT6L
Integrator complex subunit 6-like

1

1

High-throughput

0.489

High

923541

GPN2
GPN-loop GTPase 2

1

5

High-throughput

0.489

High

923564

GPN3
GPN-loop GTPase 3

1

5

High-throughput

0.489

High

421776

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

923482

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

Small-scale

0.480

High

923571

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

172609

XPO1
Exportin-1

1

1

High-throughput

0.479

High

371551

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

405935

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

923487

H4
Histone H4

1

1

High-throughput

0.479

High

923501

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

2

High-throughput

0.479

High

923559

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

5

High-throughput

0.479

High

259674

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

316272

RECQ5
ATP-dependent DNA helicase Q5

1

0

High-throughput

0.458

High

400531

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

505947

MYZAP
Myocardial zonula adherens protein

1

0

High-throughput

0.458

High

567316

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

878828

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

923504

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

High-throughput

0.458

High

923517

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

923521

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.458

High

923536

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.458

High

923539

SFR19
Splicing factor, arginine/serine-rich 19

1

0

High-throughput

0.458

High

923540

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.458

High

923549

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.458

High

923557

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

923562

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

516829

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

3

High-throughput

0.445

High

293416

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

506004

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.426

High

923483

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.426

High

923524

DAA10
Dynein axonemal assembly factor 10

2

0

High-throughput

0.318

High

923547

PDRG1
p53 and DNA damage-regulated protein 1

2

0

High-throughput

0.318

High

923503

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

2

0

High-throughput

0.305

High

182094

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.279

Low

923492

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

0

High-throughput

0.279

Low

923531

TNG6
Transport and Golgi organization protein 6 homolog

1

0

High-throughput

0.279

Low

923560

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.279

Low

923507

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.249

Low

923556

ASND1
Asparagine synthetase domain-containing protein 1

1

0

High-throughput

0.249

Low

117728

ASURF
ASNSD1 upstream open reading frame protein

1

0

High-throughput

0.232

Low

923523

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025