Protein: TPC1
Two pore channel protein 1 (Two pore calcium channel protein 1) (Voltage-dependent calcium channel protein TPC1)

Gene: TPC1, TPCN1
Organism: Homo sapiens
Interactions: 33
UniProt ID: Q9ULQ1

Gene Ontology (top 5):
GO:0005248 - voltage-gated sodium channel activity
GO:0005764 - lysosome
GO:0005765 - lysosomal membrane
GO:0005768 - endosome
GO:0010008 - endosome membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1340752

TPC2
Two pore channel protein 2

1

10

Small-scale

0.665

High

1366302

LPAR1
Lysophosphatidic acid receptor 1

2

6

High-throughput

0.628

High

1461661

TPC1
Two pore channel protein 1

1

10

Small-scale

0.618

High

622708

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

5

High-throughput

0.574

High

1449111

TNR19
Tumor necrosis factor receptor superfamily member 19

2

1

High-throughput

0.574

High

1330501

LRC52
Leucine-rich repeat-containing protein 52

2

1

High-throughput

0.549

High

938301

SEC13
Protein SEC13 homolog

1

1

High-throughput

0.536

High

1432451

TTYH1
Protein tweety homolog 1

1

2

High-throughput

0.536

High

1454023

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.513

High

124533

HAX1
HCLS1-associated protein X-1

1

1

Small-scale

0.504

High

349605

TSN15
Tetraspanin-15

1

4

High-throughput

0.489

High

640483

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

2

High-throughput

0.489

High

699250

CALX
Calnexin

1

3

High-throughput

0.489

High

833886

P2RY2
P2Y purinoceptor 2

1

4

High-throughput

0.489

High

868027

GLR
Glucagon receptor

1

8

High-throughput

0.489

High

1022503

IDD
Integral membrane protein DGCR2/IDD

1

5

High-throughput

0.489

High

1101706

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

4

High-throughput

0.489

High

1438468

LPAR2
Lysophosphatidic acid receptor 2

1

6

High-throughput

0.489

High

1449107

GP173
Probable G-protein coupled receptor 173

1

2

High-throughput

0.489

High

178438

NPC1
NPC intracellular cholesterol transporter 1

1

3

High-throughput

0.479

High

218951

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

839402

MTOR
Serine/threonine-protein kinase mTOR

1

2

Small-scale

0.479

High

1404973

S1PR3
Sphingosine 1-phosphate receptor 3

1

6

High-throughput

0.407

High

1358037

TM171
Transmembrane protein 171

4

0

High-throughput

0.360

High

829937

PMEL
Melanocyte protein PMEL

2

0

High-throughput

0.328

High

1438433

POPD2
Popeye domain-containing protein 2

2

0

High-throughput

0.318

High

914372

EFNA4
Ephrin-A4

1

0

High-throughput

0.279

Low

1203832

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

1239071

NIPA3
Magnesium transporter NIPA3

1

0

High-throughput

0.279

Low

1277748

TMC4
Voltage-gated chloride channel TMC4

1

0

High-throughput

0.279

Low

1382240

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.279

Low

1388219

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025