Protein: PMEL
Melanocyte protein PMEL (ME20-M) (ME20M) (Melanocyte protein Pmel 17) (Melanocytes lineage-specific antigen GP100) (Melanoma-associated ME20 antigen) (P1) (P100) (Premelanosome protein) (Silver locus protein homolog) [Cleaved into: M-alpha (95 kDa melanocyte-specific secreted glycoprotein) (P26) (Secreted melanoma-associated ME20 antigen) (ME20-S) (ME20S); M-beta]

Gene: PMEL
Organism: Homo sapiens
Interactions: 66
UniProt ID: P40967

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane
GO:0032438 - melanosome organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

829928

ANTR1
Anthrax toxin receptor 1

3

0

High-throughput

0.634

High

829911

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

2

5

High-throughput

0.628

High

829888

PMEL
Melanocyte protein PMEL

2

0

Small-scale

0.615

High

249237

MA1A2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

2

0

High-throughput

0.602

High

467821

BGLR
Beta-glucuronidase

2

0

High-throughput

0.602

High

658859

PTPRD
Receptor-type tyrosine-protein phosphatase delta

2

0

High-throughput

0.602

High

714584

TYK2
Non-receptor tyrosine-protein kinase TYK2

2

0

High-throughput

0.602

High

732800

GLPK
Glycerol kinase

2

0

High-throughput

0.602

High

829898

TMTC4
Protein O-mannosyl-transferase TMTC4

2

0

High-throughput

0.602

High

829899

RETST
All-trans-retinol 13,14-reductase

2

0

High-throughput

0.602

High

829900

MFS12
Major facilitator superfamily domain-containing protein 12

2

0

High-throughput

0.602

High

829906

DGLB
Diacylglycerol lipase-beta

2

0

High-throughput

0.602

High

829908

RDH11
Retinol dehydrogenase 11

2

0

High-throughput

0.602

High

829913

RB39B
Ras-related protein Rab-39B

2

0

High-throughput

0.602

High

829919

CGRF1
Cell growth regulator with RING finger domain protein 1

2

0

High-throughput

0.602

High

829921

PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

2

0

High-throughput

0.602

High

829923

CQ080
Mitochondrial nucleoid-associated protein 1

2

0

High-throughput

0.602

High

829932

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

2

0

High-throughput

0.602

High

829938

S27A6
Long-chain fatty acid transport protein 6

2

0

High-throughput

0.602

High

332204

UCP5
Brain mitochondrial carrier protein 1

1

1

High-throughput

0.536

High

565569

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

5

High-throughput

0.536

High

829889

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.536

High

829891

S26A2
Sulfate transporter

1

1

High-throughput

0.536

High

829905

S39AB
Zinc transporter ZIP11

1

1

High-throughput

0.536

High

829922

S39A3
Zinc transporter ZIP3

1

1

High-throughput

0.536

High

829925

S26A6
Solute carrier family 26 member 6

1

1

High-throughput

0.536

High

829901

ZNT6
Zinc transporter 6

1

0

High-throughput

0.513

High

829907

GLT11
Polypeptide N-acetylgalactosaminyltransferase 11

1

0

High-throughput

0.513

High

829909

ELYS
Protein ELYS

1

0

High-throughput

0.513

High

829910

AP3S1
AP-3 complex subunit sigma-1

1

0

High-throughput

0.513

High

829912

S67A1
Solute carrier family 67 member A1

1

0

High-throughput

0.513

High

829920

ABCA3
Phospholipid-transporting ATPase ABCA3

1

0

High-throughput

0.513

High

829927

TM39B
Transmembrane protein 39B

1

0

High-throughput

0.513

High

829931

ARL8B
ADP-ribosylation factor-like protein 8B

1

0

High-throughput

0.513

High

829934

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.513

High

552152

ADT3
ADP/ATP translocase 3

1

1

High-throughput

0.489

High

342778

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

397583

NU1M
NADH-ubiquinone oxidoreductase chain 1

2

0

High-throughput

0.328

High

450172

GDN
Glia-derived nexin

2

0

High-throughput

0.328

High

829892

CLCN7
H(+)/Cl(-) exchange transporter 7

2

0

High-throughput

0.328

High

829894

STAR3
StAR-related lipid transfer protein 3

2

0

High-throughput

0.328

High

829895

OZF
Zinc finger protein OZF

2

0

High-throughput

0.328

High

829903

DEN6A
Protein DENND6A

2

0

High-throughput

0.328

High

829914

RSPRY
RING finger and SPRY domain-containing protein 1

2

0

High-throughput

0.328

High

829915

SPDLY
Protein Spindly

2

0

High-throughput

0.328

High

829916

INT4
Integrator complex subunit 4

2

0

High-throughput

0.328

High

829917

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

2

0

High-throughput

0.328

High

829918

RBM15
RNA-binding protein 15

2

0

High-throughput

0.328

High

829924

GTPB2
GTP-binding protein 2

2

0

High-throughput

0.328

High

829930

INT7
Integrator complex subunit 7

2

0

High-throughput

0.328

High

829936

NOCT
Nocturnin

2

0

High-throughput

0.328

High

829937

TPC1
Two pore channel protein 1

2

0

High-throughput

0.328

High

829935

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

2

0

High-throughput

0.313

High

133849

FOXN3
Forkhead box protein N3

1

0

High-throughput

0.279

Low

829890

SYHM
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

829893

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.279

Low

829904

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.279

Low

829926

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

0

High-throughput

0.279

Low

829929

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

0

High-throughput

0.279

Low

829933

GSKIP
GSK3B-interacting protein

1

0

High-throughput

0.279

Low

829939

SNX14
Sorting nexin-14

1

0

High-throughput

0.279

Low

325712

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.249

Low

829896

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

829897

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.232

Low

829902

LRRN1
Leucine-rich repeat neuronal protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025