Protein: TPC2
Two pore channel protein 2 (Two pore calcium channel protein 2)

Gene: TPC2, TPCN2
Organism: Homo sapiens
Interactions: 65
UniProt ID: Q8NHX9

Gene Ontology (top 5):
GO:0005245 - voltage-gated calcium channel activity
GO:0005262 - calcium channel activity
GO:0005764 - lysosome
GO:0005765 - lysosomal membrane
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1340752

TPC1
Two pore channel protein 1

1

10

Small-scale

0.665

High

158856

AP3D1
AP-3 complex subunit delta-1

2

1

High-throughput

0.628

High

162015

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

2

2

High-throughput

0.628

High

541601

FGFR1
Fibroblast growth factor receptor 1

2

15

High-throughput

0.628

High

989363

VAMP2
Vesicle-associated membrane protein 2

2

2

High-throughput

0.628

High

1154684

VAMP3
Vesicle-associated membrane protein 3

2

2

High-throughput

0.628

High

1206335

WDR44
WD repeat-containing protein 44

2

7

High-throughput

0.628

High

1338618

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

2

3

High-throughput

0.628

High

1340735

TR19L
Tumor necrosis factor receptor superfamily member 19L

2

1

High-throughput

0.628

High

1340738

ANR27
Ankyrin repeat domain-containing protein 27

2

6

High-throughput

0.628

High

1340747

RAB6B
Ras-related protein Rab-6B

2

7

High-throughput

0.628

High

1340751

DP13A
DCC-interacting protein 13-alpha

2

2

High-throughput

0.628

High

1340732

TPC2
Two pore channel protein 2

1

10

Small-scale

0.618

High

126153

AP3B1
AP-3 complex subunit beta-1

2

0

High-throughput

0.602

High

226140

STX6
Syntaxin-6

2

0

High-throughput

0.602

High

732651

ARRB2
Beta-arrestin-2

2

0

High-throughput

0.602

High

907721

CLCN3
H(+)/Cl(-) exchange transporter 3

2

0

High-throughput

0.602

High

1034027

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

0

High-throughput

0.602

High

1219781

RRAGB
Ras-related GTP-binding protein B

2

0

High-throughput

0.602

High

1307830

TPPC5
Trafficking protein particle complex subunit 5

2

0

High-throughput

0.602

High

1310050

DEN6A
Protein DENND6A

2

0

High-throughput

0.602

High

1335558

DGLB
Diacylglycerol lipase-beta

2

0

High-throughput

0.602

High

1336702

CBPC5
Cytosolic carboxypeptidase-like protein 5

2

0

High-throughput

0.602

High

1340739

NFIP1
NEDD4 family-interacting protein 1

2

0

High-throughput

0.602

High

1340742

WDR11
WD repeat-containing protein 11

2

0

High-throughput

0.602

High

1340748

ZDH18
Palmitoyltransferase ZDHHC18

2

0

High-throughput

0.602

High

1340749

TSR3
18S rRNA aminocarboxypropyltransferase

2

0

High-throughput

0.602

High

1340750

FBX10
F-box only protein 10

2

0

High-throughput

0.602

High

1340753

TPPC8
Trafficking protein particle complex subunit 8

2

0

High-throughput

0.602

High

212081

B4GT5
Beta-1,4-galactosyltransferase 5

2

1

High-throughput

0.574

High

614711

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

2

10

High-throughput

0.574

High

787210

BMR1A
Bone morphogenetic protein receptor type-1A

2

5

High-throughput

0.574

High

1143642

NOMO1
BOS complex subunit NOMO1

2

1

High-throughput

0.574

High

1204433

ZRAB3
DNA annealing helicase and endonuclease ZRANB3

2

2

High-throughput

0.574

High

1278293

LRP10
Low-density lipoprotein receptor-related protein 10

2

5

High-throughput

0.574

High

1334382

UXS1
UDP-glucuronic acid decarboxylase 1

2

1

High-throughput

0.574

High

1340745

PCDH9
Protocadherin-9

2

20

High-throughput

0.574

High

1340746

CD320
CD320 antigen

2

7

High-throughput

0.574

High

1340754

KC1G3
Casein kinase I isoform gamma-3

2

2

High-throughput

0.574

High

770740

ADA1A
Alpha-1A adrenergic receptor

1

1

High-throughput

0.541

High

828229

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

High-throughput

0.536

High

914156

HXK3
Hexokinase-3

1

1

High-throughput

0.536

High

1340744

TTYH1
Protein tweety homolog 1

1

2

High-throughput

0.536

High

124410

HAX1
HCLS1-associated protein X-1

1

1

Small-scale

0.523

High

536274

PPAL
Lysosomal acid phosphatase

1

0

High-throughput

0.513

High

1139020

SNX17
Sorting nexin-17

1

0

High-throughput

0.513

High

1340740

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

1

0

High-throughput

0.513

High

1340741

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.513

High

658913

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

9

High-throughput

0.489

High

999542

NOMO3
BOS complex subunit NOMO3

1

1

High-throughput

0.489

High

1334471

RN149
E3 ubiquitin-protein ligase RNF149

1

3

High-throughput

0.489

High

1340734

AP3S1
AP-3 complex subunit sigma-1

1

3

High-throughput

0.489

High

1340743

EHD4
EH domain-containing protein 4

1

2

High-throughput

0.489

High

178340

NPC1
NPC intracellular cholesterol transporter 1

1

3

High-throughput

0.479

High

839323

MTOR
Serine/threonine-protein kinase mTOR

1

2

Small-scale

0.479

High

959004

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

1130709

DIP2A
Disco-interacting protein 2 homolog A

2

0

High-throughput

0.328

High

1340733

CERK1
Ceramide kinase

2

0

High-throughput

0.328

High

1340737

TLCD4
TLC domain-containing protein 4

2

0

High-throughput

0.328

High

248490

O10H2
Olfactory receptor 10H2

1

0

High-throughput

0.279

Low

1142893

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

0

High-throughput

0.279

Low

1243391

TM154
Transmembrane protein 154

1

0

High-throughput

0.279

Low

1340736

TV23C
Golgi apparatus membrane protein TVP23 homolog C

1

0

High-throughput

0.279

Low

70011

D11L8
Putative ATP-dependent DNA helicase DDX11-like protein 8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025