Protein: ITIH4
Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4]

Gene: ITIH4
Organism: Homo sapiens
Interactions: 34
UniProt ID: Q14624

Gene Ontology (top 5):
GO:0004866 - endopeptidase inhibitor activity
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0006953 - acute-phase response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

133025

MATN2
Matrilin-2

1

4

High-throughput

0.691

High

210751

KLK10
Kallikrein-10

1

4

High-throughput

0.691

High

188886

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.665

High

449604

KLK1
Kallikrein-1

1

5

Small-scale

0.647

High

369868

CO3
Complement C3

1

1

High-throughput

0.618

High

683723

PTX3
Pentraxin-related protein PTX3

1

1

Small-scale

0.536

High

194468

P2RX6
P2X purinoceptor 6

1

1

High-throughput

0.536

High

733351

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.536

High

1128888

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

2

High-throughput

0.536

High

1128880

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

2

High-throughput

0.489

High

1128883

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.489

High

1128884

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

2

High-throughput

0.489

High

1128887

PHF11
PHD finger protein 11

1

2

High-throughput

0.489

High

987645

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.486

High

125456

LEG9
Galectin-9

1

2

Small-scale

0.479

High

223041

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

345817

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

389363

FINC
Fibronectin

1

6

Small-scale

0.479

High

425222

IC1
Plasma protease C1 inhibitor

1

2

High-throughput

0.479

High

590905

TIMP2
Metalloproteinase inhibitor 2

1

2

High-throughput

0.479

High

609677

LEG3
Galectin-3

1

2

Small-scale

0.479

High

1113111

CUL3
Cullin-3

1

3

High-throughput

0.479

High

529800

TAU
Microtubule-associated protein tau

1

4

Small-scale

0.445

High

127331

LEG8
Galectin-8

1

2

Small-scale

0.437

High

330966

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.437

High

872324

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.437

High

1128879

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

1128882

BRWD3
Bromodomain and WD repeat-containing protein 3

1

2

High-throughput

0.437

High

1128886

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

1128881

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.407

High

1128885

P63
Tumor protein 63

1

0

High-throughput

0.251

Low

157375

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

879087

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

1026380

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025