Protein: EAF1
ELL-associated factor 1

Gene: EAF1
Organism: Homo sapiens
Interactions: 145
UniProt ID: Q96JC9

Gene Ontology (top 5):
GO:0003711 - transcription elongation factor activity
GO:0005654 - nucleoplasm
GO:0006368 - transcription elongation by RNA polymerase II
GO:0008023 - transcription elongation factor complex
GO:0015030 - Cajal body

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

936615

ELL
RNA polymerase II elongation factor ELL

9

5

Small-scale

0.973

High

137342

ELL2
RNA polymerase II elongation factor ELL2

8

5

Small-scale

0.968

High

1394891

ELL3
RNA polymerase II elongation factor ELL3

7

5

High-throughput

0.964

High

960525

PSME3
Proteasome activator complex subunit 3

5

1

High-throughput

0.726

High

839914

AF9
Protein AF-9

5

1

Small-scale

0.718

High

908290

AFF1
AF4/FMR2 family member 1

4

2

High-throughput

0.699

High

1394900

AFF4
AF4/FMR2 family member 4

4

3

High-throughput

0.699

High

872000

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

4

4

High-throughput

0.691

High

1349212

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

4

4

High-throughput

0.691

High

1394892

E41L5
Band 4.1-like protein 5

4

2

High-throughput

0.691

High

1394907

ICE1
Little elongation complex subunit 1

5

0

High-throughput

0.686

High

1225999

ICE2
Little elongation complex subunit 2

4

0

High-throughput

0.670

High

1006163

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

3

4

High-throughput

0.667

High

1040749

ENL
Protein ENL

3

1

High-throughput

0.667

High

1394880

KLDC3
Kelch domain-containing protein 3

3

1

High-throughput

0.667

High

1394908

LC7L2
Putative RNA-binding protein Luc7-like 2

3

2

High-throughput

0.667

High

1394876

STAC3
SH3 and cysteine-rich domain-containing protein 3

3

2

High-throughput

0.654

High

1367958

TF2H4
General transcription factor IIH subunit 4

3

1

High-throughput

0.647

High

340772

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

3

0

High-throughput

0.638

High

542161

TOP1
DNA topoisomerase 1

3

0

High-throughput

0.638

High

1150309

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

3

0

High-throughput

0.638

High

1150342

TAF1A
TATA box-binding protein-associated factor RNA polymerase I subunit A

3

0

High-throughput

0.638

High

1200514

TAF1B
TATA box-binding protein-associated factor RNA polymerase I subunit B

3

0

High-throughput

0.638

High

1385962

EAF2
ELL-associated factor 2

3

0

High-throughput

0.638

High

1394889

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

3

0

High-throughput

0.638

High

1394899

IKBL1
NF-kappa-B inhibitor-like protein 1

3

0

High-throughput

0.638

High

1394910

CABIN
Calcineurin-binding protein cabin-1

3

0

High-throughput

0.638

High

897940

CDK9
Cyclin-dependent kinase 9

3

0

Small-scale

0.632

High

744682

TF2H1
General transcription factor IIH subunit 1

3

0

High-throughput

0.620

High

269804

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

3

1

High-throughput

0.609

High

1219040

RSBN1
Lysine-specific demethylase 9

3

1

High-throughput

0.609

High

1243582

RSBNL
Lysine-specific demethylase RSBN1L

3

1

High-throughput

0.609

High

1394886

E41LB
Band 4.1-like protein 4B

3

2

High-throughput

0.609

High

1394894

LUC7L
Putative RNA-binding protein Luc7-like 1

3

2

High-throughput

0.609

High

1121499

KEAP1
Kelch-like ECH-associated protein 1

2

1

High-throughput

0.606

High

1150155

TCEA2
Transcription elongation factor A protein 2

2

4

High-throughput

0.606

High

1195583

ARI4B
AT-rich interactive domain-containing protein 4B

2

1

High-throughput

0.606

High

1314038

YAF2
YY1-associated factor 2

2

1

High-throughput

0.606

High

1326032

RYBP
RING1 and YY1-binding protein

2

1

High-throughput

0.606

High

1352197

GRHL3
Grainyhead-like protein 3 homolog

2

1

High-throughput

0.606

High

1219918

USPL1
SUMO-specific isopeptidase USPL1

2

0

High-throughput

0.602

High

770412

T2FA
General transcription factor IIF subunit 1

2

0

High-throughput

0.585

High

1384678

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

2

0

High-throughput

0.585

High

1394909

RBMX2
RNA-binding motif protein, X-linked 2

2

0

High-throughput

0.585

High

1323129

CCAR2
Cell cycle and apoptosis regulator protein 2

2

1

Small-scale

0.584

High

1330675

BEND7
BEN domain-containing protein 7

2

1

High-throughput

0.584

High

269345

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

326417

ZN202
Zinc finger protein 202

2

0

High-throughput

0.580

High

335291

TFIP8
Tumor necrosis factor alpha-induced protein 8

2

0

High-throughput

0.580

High

353729

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.580

High

685308

PAX6
Paired box protein Pax-6

2

0

High-throughput

0.580

High

913893

ZN143
Zinc finger protein 143

2

0

High-throughput

0.580

High

1090855

TRAF2
TNF receptor-associated factor 2

2

0

High-throughput

0.580

High

1271201

DPPA4
Developmental pluripotency-associated protein 4

2

0

High-throughput

0.580

High

1347044

G45IP
Large ribosomal subunit protein mL64

2

0

High-throughput

0.580

High

1394885

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

2

0

High-throughput

0.580

High

1061826

TLE5
TLE family member 5

2

1

High-throughput

0.576

High

1332266

TAC2N
Tandem C2 domains nuclear protein

2

1

High-throughput

0.574

High

140405

SDCB1
Syntenin-1

1

2

High-throughput

0.573

High

1086286

TFCP2
Alpha-globin transcription factor CP2

1

1

High-throughput

0.573

High

1100243

TIF1B
Transcription intermediary factor 1-beta

1

2

Small-scale

0.561

High

65135

GG6L9
Golgin subfamily A member 6-like protein 9

2

1

High-throughput

0.553

High

1210145

VAX1
Ventral anterior homeobox 1

2

1

High-throughput

0.553

High

229354

ZBT14
Zinc finger and BTB domain-containing protein 14

1

0

High-throughput

0.549

High

336021

MED26
Mediator of RNA polymerase II transcription subunit 26

1

1

High-throughput

0.536

High

503647

TFPT
TCF3 fusion partner

1

1

Small-scale

0.515

High

422890

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

173234

XPO1
Exportin-1

1

2

High-throughput

0.479

High

330494

LC7L3
Luc7-like protein 3

1

2

High-throughput

0.479

High

1115911

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.479

High

1394890

SP110
Sp110 nuclear body protein

1

1

High-throughput

0.479

High

188341

HDAC3
Histone deacetylase 3

1

0

Small-scale

0.458

High

212307

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

0

High-throughput

0.458

High

669973

MCM3
DNA replication licensing factor MCM3

1

0

High-throughput

0.458

High

703028

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

855495

ATRX
Transcriptional regulator ATRX

1

0

High-throughput

0.458

High

935602

MFAP1
Microfibrillar-associated protein 1

1

0

High-throughput

0.458

High

1134513

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

0

High-throughput

0.458

High

1248062

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.458

High

1393394

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.458

High

1394878

RBM14
RNA-binding protein 14

1

0

High-throughput

0.458

High

1394901

DDX20
Probable ATP-dependent RNA helicase DDX20

1

0

High-throughput

0.458

High

245811

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

4

High-throughput

0.445

High

714355

PML
Protein PML

1

1

High-throughput

0.445

High

1312878

KLHL7
Kelch-like protein 7

1

1

High-throughput

0.445

High

1394904

RUVB2
RuvB-like 2

1

1

High-throughput

0.445

High

1394906

RUVB1
RuvB-like 1

1

1

High-throughput

0.445

High

889325

NUMB
Protein numb homolog

1

1

High-throughput

0.439

High

317208

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.426

High

622844

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

0

High-throughput

0.426

High

1118849

TF2H3
General transcription factor IIH subunit 3

1

0

High-throughput

0.426

High

1240798

T2H2L
General transcription factor IIH subunit 2-like protein

1

0

High-throughput

0.426

High

1394897

MRGBP
MRG/MORF4L-binding protein

1

0

High-throughput

0.426

High

1394905

HPSE
Heparanase

1

0

High-throughput

0.426

High

168887

PLD2
Phospholipase D2

1

1

High-throughput

0.407

High

1103786

PLD1
Phospholipase D1

1

1

High-throughput

0.407

High

1394877

AGAP3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

1

1

High-throughput

0.407

High

1394888

E41L1
Band 4.1-like protein 1

1

2

High-throughput

0.407

High

1394903

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

2

High-throughput

0.407

High

1394896

HOME3
Homer protein homolog 3

4

0

High-throughput

0.367

High

1325073

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

4

0

High-throughput

0.360

High

1385375

FGGY
FGGY carbohydrate kinase domain-containing protein

3

0

High-throughput

0.342

High

1335371

CAMKV
CaM kinase-like vesicle-associated protein

2

0

High-throughput

0.328

High

1088283

SFSWA
Splicing factor, suppressor of white-apricot homolog

2

0

High-throughput

0.318

High

1212083

SPOUT
28S rRNA

2

0

High-throughput

0.318

High

1394902

RL26L
Ribosomal protein uL24-like

2

0

High-throughput

0.318

High

407881

SEMG1
Semenogelin-1

2

0

High-throughput

0.316

High

619262

TNNI1
Troponin I, slow skeletal muscle

2

0

High-throughput

0.316

High

788745

SRP14
Signal recognition particle 14 kDa protein

2

0

High-throughput

0.316

High

1205800

GSAML
Germinal center-associated signaling and motility-like protein

2

0

High-throughput

0.316

High

1244636

GASP3
G protein-coupled receptor associated sorting protein 3

2

0

High-throughput

0.316

High

1253079

ZN620
Zinc finger protein 620

2

0

High-throughput

0.316

High

1287048

K1328
Protein hinderin

2

0

High-throughput

0.316

High

1292100

F228A
Protein FAM228A

2

0

High-throughput

0.316

High

1331422

MB213
Protein mab-21-like 3

2

0

High-throughput

0.316

High

1336141

CC150
Coiled-coil domain-containing protein 150

2

0

High-throughput

0.316

High

1340310

CEP70
Centrosomal protein of 70 kDa

2

0

High-throughput

0.316

High

1386667

AP2M1
AP-2 complex subunit mu

2

0

High-throughput

0.316

High

1394883

TRI62
E3 ubiquitin-protein ligase TRIM62

2

0

High-throughput

0.316

High

1394895

PICK1
PRKCA-binding protein

2

0

High-throughput

0.316

High

1394898

PIHD1
PIH1 domain-containing protein 1

2

0

High-throughput

0.316

High

1347442

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.299

High

1350345

MIPO1
Mirror-image polydactyly gene 1 protein

1

0

High-throughput

0.299

High

959384

RAP1B
Ras-related protein Rap-1b

1

0

High-throughput

0.279

Low

1325658

FGRL1
Fibroblast growth factor receptor-like 1

1

0

High-throughput

0.279

Low

1328388

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.265

Low

1280039

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

0

High-throughput

0.251

Low

65926

CC154
Coiled-coil domain-containing protein 154

1

0

High-throughput

0.249

Low

126167

AP3B1
AP-3 complex subunit beta-1

1

0

High-throughput

0.249

Low

862936

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.249

Low

1149495

SP17
Sperm surface protein Sp17

1

0

High-throughput

0.249

Low

1316858

ASPM
Abnormal spindle-like microcephaly-associated protein

1

0

High-throughput

0.249

Low

1394881

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

1

0

High-throughput

0.249

Low

1394882

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.249

Low

50831

CA226
Uncharacterized protein C1orf226

1

0

High-throughput

0.232

Low

626974

FST
Follistatin

1

0

High-throughput

0.232

Low

1030328

AMPD2
AMP deaminase 2

1

0

High-throughput

0.232

Low

1058915

ZO1
Tight junction protein 1

1

0

High-throughput

0.232

Low

1195307

TB10B
TBC1 domain family member 10B

1

0

High-throughput

0.232

Low

1257806

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.232

Low

1346614

VANG1
Vang-like protein 1

1

0

High-throughput

0.232

Low

1394879

SNX18
Sorting nexin-18

1

0

High-throughput

0.232

Low

1394884

OSBL6
Oxysterol-binding protein-related protein 6

1

0

High-throughput

0.232

Low

1394887

SMOC1
SPARC-related modular calcium-binding protein 1

1

0

High-throughput

0.232

Low

1394893

XAGE1
X antigen family member 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025