Protein: DNLI4
DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4)

Gene: DNLI4, LIG4
Organism: Homo sapiens
Interactions: 141
UniProt ID: P49917

Gene Ontology (top 5):
GO:0000012 - single strand break repair
GO:0000287 - magnesium ion binding
GO:0000781 - chromosome, telomeric region
GO:0000793 - condensed chromosome
GO:0001701 - in utero embryonic development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

892676

XRCC4
DNA repair protein XRCC4

23

1

Small-scale

0.992

High

557952

XRCC6
X-ray repair cross-complementing protein 6

4

6

Small-scale

0.886

High

559268

XRCC5
X-ray repair cross-complementing protein 5

3

6

Small-scale

0.827

High

892694

APLF
Aprataxin and PNK-like factor

6

1

Small-scale

0.730

High

892667

PRKDC
DNA-dependent protein kinase catalytic subunit

3

3

Small-scale

0.655

High

892716

DCR1C
Protein artemis

2

0

Small-scale

0.635

High

876776

KC1A
Casein kinase I isoform alpha

2

1

High-throughput

0.628

High

892727

NHEJ1
Non-homologous end-joining factor 1

3

0

Small-scale

0.622

High

892718

PNKP
Bifunctional polynucleotide phosphatase/kinase

2

3

Small-scale

0.601

High

460911

LDHC
L-lactate dehydrogenase C chain

1

2

High-throughput

0.552

High

484998

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.552

High

621450

HXK1
Hexokinase-1

1

1

High-throughput

0.552

High

705807

AMPL
Cytosol aminopeptidase

1

1

High-throughput

0.552

High

783534

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

1

High-throughput

0.552

High

892662

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.552

High

892665

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.552

High

892670

TLE4
Transducin-like enhancer protein 4

1

1

High-throughput

0.552

High

892672

TP53B
TP53-binding protein 1

1

2

High-throughput

0.552

High

892704

ALMS1
Centrosome-associated protein ALMS1

1

1

High-throughput

0.552

High

892739

RUVB2
RuvB-like 2

1

2

High-throughput

0.552

High

333971

SMC2
Structural maintenance of chromosomes protein 2

1

0

Small-scale

0.549

High

892705

PHF10
PHD finger protein 10

1

4

High-throughput

0.541

High

877063

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.536

High

892690

APTX
Aprataxin

1

3

High-throughput

0.536

High

892721

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.536

High

64706

PGP
Glycerol-3-phosphate phosphatase

1

0

High-throughput

0.529

High

445784

ENOA
Alpha-enolase

1

0

High-throughput

0.529

High

657892

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

0

High-throughput

0.529

High

892658

BTG1
Protein BTG1

1

0

High-throughput

0.529

High

892679

THOC5
THO complex subunit 5

1

0

High-throughput

0.529

High

892686

AFTIN
Aftiphilin

1

0

High-throughput

0.529

High

892698

OXR1
Oxidation resistance protein 1

1

0

High-throughput

0.529

High

892706

PALLD
Palladin

1

0

High-throughput

0.529

High

892708

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.529

High

892719

NEUR1
Sialidase-1

1

0

High-throughput

0.529

High

892729

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.529

High

892682

SWAHC
Ankyrin repeat domain-containing protein SOWAHC

1

0

High-throughput

0.519

High

892714

AGAP4
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4

1

0

High-throughput

0.519

High

851848

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.518

High

892702

ZSC18
Zinc finger and SCAN domain-containing protein 18

1

0

High-throughput

0.518

High

892674

ATM
Serine-protein kinase ATM

1

3

Small-scale

0.516

High

892150

GRAK
Granzyme K

1

1

High-throughput

0.494

High

397674

NU4M
NADH-ubiquinone oxidoreductase chain 4

1

1

High-throughput

0.481

High

507119

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

1

High-throughput

0.481

High

567306

TCTP
Translationally-controlled tumor protein

1

1

High-throughput

0.481

High

650646

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

1

High-throughput

0.481

High

755669

MCM4
DNA replication licensing factor MCM4

1

1

High-throughput

0.481

High

892654

IF4A1
Eukaryotic initiation factor 4A-I

1

1

High-throughput

0.481

High

892680

DGUOK
Deoxyguanosine kinase, mitochondrial

1

1

High-throughput

0.481

High

892703

WDR20
WD repeat-containing protein 20

1

1

High-throughput

0.481

High

892707

CBP
CREB-binding protein

1

2

High-throughput

0.481

High

892720

CPNE1
Copine-1

1

1

High-throughput

0.481

High

892730

DD19A
ATP-dependent RNA helicase DDX19A

1

1

High-throughput

0.481

High

358643

LDHA
L-lactate dehydrogenase A chain

1

2

High-throughput

0.479

High

851725

NKX21
Homeobox protein Nkx-2.1

1

3

High-throughput

0.479

High

892673

STRN3
Striatin-3

1

1

High-throughput

0.479

High

892717

CRBN
Protein cereblon

1

1

Small-scale

0.479

High

892724

MTA3
Metastasis-associated protein MTA3

1

1

High-throughput

0.479

High

329909

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.460

High

408742

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.460

High

424371

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.460

High

533624

CLUS
Clusterin

1

0

High-throughput

0.460

High

846127

CATK
Cathepsin K

1

0

High-throughput

0.460

High

892652

RBM5
RNA-binding protein 5

1

0

High-throughput

0.460

High

892655

PSA6
Proteasome subunit alpha type-6

1

0

High-throughput

0.460

High

892660

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.460

High

892663

ACTG
Actin, cytoplasmic 2

1

0

High-throughput

0.460

High

892664

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

0

High-throughput

0.460

High

892668

SRSF2
Serine/arginine-rich splicing factor 2

1

0

High-throughput

0.460

High

892681

ATOSA
Atos homolog protein A

1

0

High-throughput

0.460

High

892684

RHBD2
Rhomboid domain-containing protein 2

1

0

High-throughput

0.460

High

892687

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.460

High

892693

AROS
Active regulator of SIRT1

1

0

High-throughput

0.460

High

892695

ASPM
Abnormal spindle-like microcephaly-associated protein

1

0

High-throughput

0.460

High

892696

SYCP3
Synaptonemal complex protein 3

1

0

High-throughput

0.460

High

892697

OGFD1
Prolyl 3-hydroxylase OGFOD1

1

0

High-throughput

0.460

High

892699

COMD1
COMM domain-containing protein 1

1

0

High-throughput

0.460

High

892700

ZFN2A
AN1-type zinc finger protein 2A

1

0

High-throughput

0.460

High

892712

MCRS1
Microspherule protein 1

1

0

High-throughput

0.460

High

892723

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

1

0

High-throughput

0.460

High

892733

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

High-throughput

0.460

High

892736

APC10
Anaphase-promoting complex subunit 10

1

0

High-throughput

0.460

High

892737

B9D1
B9 domain-containing protein 1

1

0

High-throughput

0.460

High

892738

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.460

High

892741

KIF3A
Kinesin-like protein KIF3A

1

0

High-throughput

0.460

High

402558

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.458

High

459504

PROF1
Profilin-1

1

0

High-throughput

0.458

High

479783

GSTP1
Glutathione S-transferase P

1

0

High-throughput

0.458

High

637405

FLNA
Filamin-A

1

0

High-throughput

0.458

High

892653

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

892661

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.458

High

892689

MICA3
[F-actin]-monooxygenase MICAL3

1

0

High-throughput

0.458

High

892691

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

892709

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

892711

COA7
Cytochrome c oxidase assembly factor 7

1

0

High-throughput

0.458

High

892713

HIC2
Hypermethylated in cancer 2 protein

1

0

High-throughput

0.458

High

892715

TRNT1
CCA tRNA nucleotidyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

892735

AGO2
Protein argonaute-2

1

0

High-throughput

0.458

High

397730

NU5M
NADH-ubiquinone oxidoreductase chain 5

1

1

High-throughput

0.439

High

892675

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

1

High-throughput

0.439

High

302785

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

1

High-throughput

0.437

High

450957

LDHB
L-lactate dehydrogenase B chain

1

2

High-throughput

0.437

High

618665

ML12A
Myosin regulatory light chain 12A

1

1

High-throughput

0.437

High

892685

PPR18
Phostensin

1

1

High-throughput

0.437

High

892688

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

892726

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

892725

PAXX
Protein PAXX

1

0

Small-scale

0.426

High

541893

TOP1
DNA topoisomerase 1

1

1

Small-scale

0.408

High

892678

ATR
Serine/threonine-protein kinase ATR

1

3

Small-scale

0.408

High

221725

TPPC3
Trafficking protein particle complex subunit 3

1

0

High-throughput

0.288

High

664957

ERD21
ER lumen protein-retaining receptor 1

1

0

High-throughput

0.288

High

892701

BBOF1
Basal body-orientation factor 1

1

0

High-throughput

0.288

High

216064

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

0

High-throughput

0.251

Low

249587

SNX3
Sorting nexin-3

1

0

High-throughput

0.251

Low

253553

PEX10
Peroxisome biogenesis factor 10

1

0

High-throughput

0.251

Low

350438

GPAN1
G patch domain and ankyrin repeat-containing protein 1

1

0

High-throughput

0.251

Low

353928

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

High-throughput

0.251

Low

360263

COX1
Cytochrome c oxidase subunit 1

1

0

High-throughput

0.251

Low

360396

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.251

Low

360716

COX3
Cytochrome c oxidase subunit 3

1

0

High-throughput

0.251

Low

397591

NU1M
NADH-ubiquinone oxidoreductase chain 1

1

0

High-throughput

0.251

Low

465950

CO1A2
Collagen alpha-2(I) chain

1

0

High-throughput

0.251

Low

892656

VA0D1
V-type proton ATPase subunit d 1

1

0

High-throughput

0.251

Low

892657

NPC2
NPC intracellular cholesterol transporter 2

1

0

High-throughput

0.251

Low

892659

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.251

Low

892666

NOMO3
BOS complex subunit NOMO3

1

0

High-throughput

0.251

Low

892669

CAP1
Adenylyl cyclase-associated protein 1

1

0

High-throughput

0.251

Low

892677

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.251

Low

892692

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.251

Low

892710

ZN428
Zinc finger protein 428

1

0

High-throughput

0.251

Low

892722

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

High-throughput

0.251

Low

892728

SEM4G
Semaphorin-4G

1

0

High-throughput

0.251

Low

892731

WBP1L
WW domain binding protein 1-like

1

0

High-throughput

0.251

Low

892732

DPP3
Dipeptidyl peptidase 3

1

0

High-throughput

0.251

Low

892734

GRHPR
Glyoxylate reductase/hydroxypyruvate reductase

1

0

High-throughput

0.251

Low

892740

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.251

Low

892742

IPP
Actin-binding protein IPP

1

0

High-throughput

0.251

Low

456207

CATD
Cathepsin D

1

0

High-throughput

0.249

Low

790876

TAGL2
Transgelin-2

1

0

High-throughput

0.249

Low

892671

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

High-throughput

0.249

Low

892683

IL23R
Interleukin-23 receptor

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025