Protein: CMTD1
Catechol O-methyltransferase domain-containing protein 1 (EC 2.1.1.-)

Gene: CMTD1, COMTD1
Organism: Homo sapiens
Interactions: 216
UniProt ID: Q86VU5

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0008171 - O-methyltransferase activity
GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity
GO:0016020 - membrane
GO:0032259 - methylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

334826

IPO7
Importin-7

3

8

High-throughput

0.667

High

926497

SYRC
Arginine--tRNA ligase, cytoplasmic

3

1

High-throughput

0.667

High

1241641

ANM9
Protein arginine N-methyltransferase 9

3

1

High-throughput

0.667

High

1291662

IPO9
Importin-9

3

8

High-throughput

0.667

High

828391

PEX19
Peroxisomal biogenesis factor 19

4

0

High-throughput

0.661

High

1291624

S39AB
Zinc transporter ZIP11

3

8

High-throughput

0.643

High

271719

HIP1R
Huntingtin-interacting protein 1-related protein

3

0

High-throughput

0.638

High

834486

SYIC
Isoleucine--tRNA ligase, cytoplasmic

3

0

High-throughput

0.638

High

1291627

STAG2
Cohesin subunit SA-2

3

0

High-throughput

0.638

High

1291630

MIGA1
Mitoguardin 1

3

0

High-throughput

0.638

High

1291638

GEMI5
Gem-associated protein 5

3

0

High-throughput

0.638

High

1291674

MSTO1
Protein misato homolog 1

3

0

High-throughput

0.638

High

1291714

COG5
Conserved oligomeric Golgi complex subunit 5

3

0

High-throughput

0.638

High

1291623

S11IP
Serine/threonine-protein kinase 11-interacting protein

4

1

High-throughput

0.630

High

1291677

XPO4
Exportin-4

4

4

High-throughput

0.630

High

1134266

IMB1
Importin subunit beta-1

2

5

High-throughput

0.628

High

460586

SYEP
Bifunctional glutamate/proline--tRNA ligase

2

2

High-throughput

0.611

High

576798

SYDC
Aspartate--tRNA ligase, cytoplasmic

2

1

High-throughput

0.611

High

890526

RBP2
E3 SUMO-protein ligase RanBP2

2

1

High-throughput

0.611

High

216100

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

3

2

High-throughput

0.609

High

585805

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

3

2

High-throughput

0.609

High

1198184

PDCD4
Programmed cell death protein 4

3

1

High-throughput

0.609

High

1208187

P4R3B
Serine/threonine-protein phosphatase 4 regulatory subunit 3B

3

1

High-throughput

0.609

High

1291539

HOOK3
Protein Hook homolog 3

3

1

High-throughput

0.609

High

1291637

CIP2A
Protein CIP2A

3

1

High-throughput

0.609

High

1291667

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

3

1

High-throughput

0.609

High

1291706

IPO11
Importin-11

3

8

High-throughput

0.609

High

1291721

TNPO3
Transportin-3

3

9

High-throughput

0.609

High

1139483

S39AE
Metal cation symporter ZIP14

2

8

High-throughput

0.601

High

164597

TNPO2
Transportin-2

3

8

High-throughput

0.599

High

1089323

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

2

0

High-throughput

0.585

High

1291703

DDX20
Probable ATP-dependent RNA helicase DDX20

2

0

High-throughput

0.585

High

1291659

CK5P3
CDK5 regulatory subunit-associated protein 3

2

0

High-throughput

0.576

High

915993

NUP98
Nuclear pore complex protein Nup98-Nup96

2

1

High-throughput

0.558

High

1095900

EI2BE
Translation initiation factor eIF2B subunit epsilon

2

3

High-throughput

0.558

High

1291633

NUP37
Nucleoporin Nup37

2

1

High-throughput

0.558

High

1120027

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

2

1

High-throughput

0.549

High

1242843

S39A4
Zinc transporter ZIP4

2

8

High-throughput

0.549

High

1291629

CCYL1
Cyclin-Y-like protein 1

2

1

High-throughput

0.549

High

1291631

CCNY
Cyclin-Y

2

1

High-throughput

0.549

High

1291689

EI2BG
Translation initiation factor eIF2B subunit gamma

2

1

High-throughput

0.549

High

396439

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

60510

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

1

1

High-throughput

0.536

High

173018

XPO1
Exportin-1

1

9

High-throughput

0.536

High

251232

RNBP6
Ran-binding protein 6

1

5

High-throughput

0.536

High

344416

TBCD8
TBC1 domain family member 8

1

1

High-throughput

0.536

High

839308

MTOR
Serine/threonine-protein kinase mTOR

1

1

High-throughput

0.536

High

841207

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.536

High

898109

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

2

High-throughput

0.536

High

934108

XPO2
Exportin-2

1

9

High-throughput

0.536

High

940271

SYMC
Methionine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.536

High

1119843

CKAP5
Cytoskeleton-associated protein 5

1

1

High-throughput

0.536

High

1124202

EI2BA
Translation initiation factor eIF2B subunit alpha

1

2

High-throughput

0.536

High

1137235

CND1
Condensin complex subunit 1

1

1

High-throughput

0.536

High

1139641

SYK
Lysine--tRNA ligase

1

1

High-throughput

0.536

High

1226403

TBC9B
TBC1 domain family member 9B

1

2

High-throughput

0.536

High

1245963

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

1

High-throughput

0.536

High

1287363

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

High-throughput

0.536

High

1291038

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

7

High-throughput

0.536

High

1291639

IPO4
Importin-4

1

6

High-throughput

0.536

High

1291644

GCN1
Stalled ribosome sensor GCN1

1

5

High-throughput

0.536

High

1291645

NU205
Nuclear pore complex protein Nup205

1

1

High-throughput

0.536

High

1291660

EXOC2
Exocyst complex component 2

1

1

High-throughput

0.536

High

1291711

UBQL1
Ubiquilin-1

1

1

High-throughput

0.523

High

299558

TRIO
Triple functional domain protein

1

1

High-throughput

0.514

High

143656

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

0

High-throughput

0.513

High

181356

PGRC2
Membrane-associated progesterone receptor component 2

1

0

High-throughput

0.513

High

211810

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.513

High

226435

SNG2
Synaptogyrin-2

1

0

High-throughput

0.513

High

248903

GSDME
Gasdermin-E

1

0

High-throughput

0.513

High

255831

USO1
General vesicular transport factor p115

1

0

High-throughput

0.513

High

319881

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.513

High

360279

COX1
Cytochrome c oxidase subunit 1

1

0

High-throughput

0.513

High

844211

ECE1
Endothelin-converting enzyme 1

1

0

High-throughput

0.513

High

944511

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.513

High

945268

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.513

High

1210348

NU188
Nucleoporin NUP188

1

0

High-throughput

0.513

High

1233751

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.513

High

1245201

BRAT1
Integrator complex assembly factor BRAT1

1

0

High-throughput

0.513

High

1273950

DYM
Dymeclin

1

0

High-throughput

0.513

High

1289002

NLRX1
NLR family member X1

1

0

High-throughput

0.513

High

1291618

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.513

High

1291622

K2013
Uncharacterized protein KIAA2013

1

0

High-throughput

0.513

High

1291625

INT1
Integrator complex subunit 1

1

0

High-throughput

0.513

High

1291641

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.513

High

1291643

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.513

High

1291648

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.513

High

1291649

EXOC4
Exocyst complex component 4

1

0

High-throughput

0.513

High

1291654

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

0

High-throughput

0.513

High

1291661

COG8
Conserved oligomeric Golgi complex subunit 8

1

0

High-throughput

0.513

High

1291665

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.513

High

1291666

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.513

High

1291673

LRRC1
Leucine-rich repeat-containing protein 1

1

0

High-throughput

0.513

High

1291675

NUP85
Nuclear pore complex protein Nup85

1

0

High-throughput

0.513

High

1291680

INT2
Integrator complex subunit 2

1

0

High-throughput

0.513

High

1291682

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.513

High

1291696

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

0

High-throughput

0.513

High

1291698

ATX10
Ataxin-10

1

0

High-throughput

0.513

High

1291699

NCDN
Neurochondrin

1

0

High-throughput

0.513

High

1291716

EXOC7
Exocyst complex component 7

1

0

High-throughput

0.513

High

189209

IPO8
Importin-8

1

8

High-throughput

0.489

High

220939

XPOT
Exportin-T

1

7

High-throughput

0.489

High

302880

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

2

High-throughput

0.489

High

316619

ST17B
Serine/threonine-protein kinase 17B

1

3

High-throughput

0.489

High

333079

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.489

High

334047

SMC2
Structural maintenance of chromosomes protein 2

1

1

High-throughput

0.489

High

762140

CNR2
Cannabinoid receptor 2

1

3

Small-scale

0.489

High

868205

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.489

High

890136

EI2BB
Translation initiation factor eIF2B subunit beta

1

2

High-throughput

0.489

High

1065965

VAC14
Protein VAC14 homolog

1

7

High-throughput

0.489

High

1234599

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

1

High-throughput

0.489

High

1259313

TBA1A
Tubulin alpha-1A chain

1

1

High-throughput

0.489

High

1291617

LIPB1
Liprin-beta-1

1

1

High-throughput

0.489

High

1291636

TBC15
TBC1 domain family member 15

1

3

High-throughput

0.489

High

1291647

TNPO1
Transportin-1

1

8

High-throughput

0.489

High

1291652

HOOK2
Protein Hook homolog 2

1

1

High-throughput

0.489

High

1291670

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.489

High

1291687

XPO5
Exportin-5

1

6

High-throughput

0.489

High

1291694

SMC4
Structural maintenance of chromosomes protein 4

1

1

High-throughput

0.489

High

1291705

EI2BD
Translation initiation factor eIF2B subunit delta

1

2

High-throughput

0.489

High

1291708

XPO7
Exportin-7

1

6

High-throughput

0.489

High

1291710

S39AA
Zinc transporter ZIP10

1

8

High-throughput

0.489

High

1291715

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

1

High-throughput

0.489

High

275054

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.479

High

1271291

5MP2
eIF5-mimic protein 2

1

2

High-throughput

0.479

High

1291646

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

653416

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

1085336

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

1

High-throughput

0.445

High

1291634

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

1

High-throughput

0.445

High

1291655

S39AD
Zinc transporter ZIP13

1

8

High-throughput

0.445

High

293953

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

1105212

S39A6
Zinc transporter ZIP6

1

8

High-throughput

0.437

High

1291681

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1291702

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

1127624

SCN5A
Sodium channel protein type 5 subunit alpha

1

0

High-throughput

0.426

High

1132290

GOGB1
Golgin subfamily B member 1

1

0

High-throughput

0.426

High

1291657

SUCB2
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.426

High

1291688

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.426

High

1291712

PCDGK
Protocadherin gamma-C3

1

0

High-throughput

0.426

High

1095555

LIPA1
Liprin-alpha-1

1

1

High-throughput

0.407

High

1195630

Q4LE60
TNPO2 variant protein

1

8

High-throughput

0.407

High

1291620

KCC1D
Calcium/calmodulin-dependent protein kinase type 1D

1

1

High-throughput

0.407

High

1291635

S7A14
Solute carrier family 7 member 14

1

2

High-throughput

0.407

High

1291671

CSTN3
Calsyntenin-3

1

1

High-throughput

0.407

High

1291679

S39A8
Metal cation symporter ZIP8

1

8

High-throughput

0.407

High

1291717

S22AE
Solute carrier family 22 member 14

1

1

High-throughput

0.407

High

1229169

INT3
Integrator complex subunit 3

4

0

High-throughput

0.360

High

1278603

HEAT3
HEAT repeat-containing protein 3

4

0

High-throughput

0.360

High

1291664

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

4

0

High-throughput

0.360

High

1291691

SOSSC
SOSS complex subunit C

4

0

High-throughput

0.360

High

136217

IFRD1
Interferon-related developmental regulator 1

3

0

High-throughput

0.347

High

167099

GEMI2
Gem-associated protein 2

3

0

High-throughput

0.347

High

251614

CCNT1
Cyclin-T1

3

0

High-throughput

0.347

High

854471

KPB1
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform

3

0

High-throughput

0.347

High

1275931

SETX
Probable helicase senataxin

3

0

High-throughput

0.347

High

1279189

WAPL
Wings apart-like protein homolog

3

0

High-throughput

0.347

High

1291621

SUGP1
SURP and G-patch domain-containing protein 1

3

0

High-throughput

0.347

High

1291650

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

3

0

High-throughput

0.347

High

1291668

HAUS7
HAUS augmin-like complex subunit 7

3

0

High-throughput

0.347

High

1291690

PNO1
RNA-binding protein PNO1

3

0

High-throughput

0.347

High

1291693

DIAP3
Protein diaphanous homolog 3

3

0

High-throughput

0.347

High

1291700

TFP11
Tuftelin-interacting protein 11

3

0

High-throughput

0.347

High

1291653

SAAL1
Protein SAAL1

3

0

High-throughput

0.339

High

243966

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

2

0

High-throughput

0.328

High

720776

PUR8
Adenylosuccinate lyase

2

0

High-throughput

0.318

High

1131878

COG2
Conserved oligomeric Golgi complex subunit 2

2

0

High-throughput

0.318

High

1291619

DAAF5
Dynein axonemal assembly factor 5

2

0

High-throughput

0.318

High

906901

GPM6A
Neuronal membrane glycoprotein M6-a

2

0

High-throughput

0.313

High

139258

UPK2
Uroplakin-2

1

0

High-throughput

0.279

Low

173719

BTAF1
TATA-binding protein-associated factor 172

1

0

High-throughput

0.279

Low

177253

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

0

High-throughput

0.279

Low

178555

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

0

High-throughput

0.279

Low

208062

TTI1
TELO2-interacting protein 1 homolog

1

0

High-throughput

0.279

Low

251782

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

0

High-throughput

0.279

Low

320880

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

0

High-throughput

0.279

Low

335625

AGM1
Phosphoacetylglucosamine mutase

1

0

High-throughput

0.279

Low

897586

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.279

Low

1013518

COG7
Conserved oligomeric Golgi complex subunit 7

1

0

High-throughput

0.279

Low

1085245

NU160
Nuclear pore complex protein Nup160

1

0

High-throughput

0.279

Low

1159728

OCLN
Occludin

1

0

High-throughput

0.279

Low

1160505

SMN
Survival motor neuron protein

1

0

High-throughput

0.279

Low

1177590

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.279

Low

1187001

TKFC
Triokinase/FMN cyclase

1

0

High-throughput

0.279

Low

1251530

THADA
tRNA

1

0

High-throughput

0.279

Low

1291626

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

High-throughput

0.279

Low

1291628

FXL16
F-box/LRR-repeat protein 16

1

0

High-throughput

0.279

Low

1291632

DIK2A
Divergent protein kinase domain 2A

1

0

High-throughput

0.279

Low

1291640

COG1
Conserved oligomeric Golgi complex subunit 1

1

0

High-throughput

0.279

Low

1291642

GEMI6
Gem-associated protein 6

1

0

High-throughput

0.279

Low

1291651

INT12
Integrator complex subunit 12

1

0

High-throughput

0.279

Low

1291656

INT4
Integrator complex subunit 4

1

0

High-throughput

0.279

Low

1291658

COG3
Conserved oligomeric Golgi complex subunit 3

1

0

High-throughput

0.279

Low

1291663

XPO6
Exportin-6

1

0

High-throughput

0.279

Low

1291669

SOSB1
SOSS complex subunit B1

1

0

High-throughput

0.279

Low

1291672

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.279

Low

1291676

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.279

Low

1291678

TTYH3
Protein tweety homolog 3

1

0

High-throughput

0.279

Low

1291683

PHAX
Phosphorylated adapter RNA export protein

1

0

High-throughput

0.279

Low

1291684

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.279

Low

1291692

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

0

High-throughput

0.279

Low

1291695

GEMI8
Gem-associated protein 8

1

0

High-throughput

0.279

Low

1291701

FA8A1
Protein FAM8A1

1

0

High-throughput

0.279

Low

1291704

GPN3
GPN-loop GTPase 3

1

0

High-throughput

0.279

Low

1291707

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.279

Low

1291709

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.279

Low

1291718

COG6
Conserved oligomeric Golgi complex subunit 6

1

0

High-throughput

0.279

Low

1291719

CAB39
Calcium-binding protein 39

1

0

High-throughput

0.279

Low

1291720

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.279

Low

1257067

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.251

Low

1291686

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.251

Low

188924

TMPS2
Transmembrane protease serine 2

1

0

High-throughput

0.249

Low

377635

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1291697

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

0

High-throughput

0.249

Low

727570

SC6A4
Sodium-dependent serotonin transporter

1

0

High-throughput

0.232

Low

1291685

S28A3
Solute carrier family 28 member 3

1

0

High-throughput

0.232

Low

1291713

SNX7
Sorting nexin-7

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025