Protein: FXL18
F-box/LRR-repeat protein 18 (F-box and leucine-rich repeat protein 18)

Gene: FXL18, FBXL18
Organism: Homo sapiens
Interactions: 55
UniProt ID: Q96ME1

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992306

SKP1
S-phase kinase-associated protein 1

3

0

Small-scale

0.816

High

1101878

SKP2
S-phase kinase-associated protein 2

2

2

High-throughput

0.811

High

1112662

CUL1
Cullin-1

3

0

Small-scale

0.811

High

1398049

FBXL7
F-box/LRR-repeat protein 7

1

1

Small-scale

0.747

High

242622

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.716

High

132241

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

2

High-throughput

0.653

High

1325786

FXL16
F-box/LRR-repeat protein 16

2

2

High-throughput

0.628

High

335701

MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

2

0

High-throughput

0.602

High

983940

RBX1
E3 ubiquitin-protein ligase RBX1

2

0

Small-scale

0.585

High

1095760

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

2

0

High-throughput

0.559

High

1372038

RBPMS
RNA-binding protein with multiple splicing

2

0

High-throughput

0.559

High

334226

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

High-throughput

0.536

High

1398041

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

0

Small-scale

0.517

High

1272525

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.513

High

1370307

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

1398046

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

949968

KR103
Keratin-associated protein 10-3

1

1

High-throughput

0.481

High

1093927

TRAF1
TNF receptor-associated factor 1

1

1

High-throughput

0.481

High

1398043

KR412
Keratin-associated protein 4-12

1

1

High-throughput

0.481

High

1398045

TRAF4
TNF receptor-associated factor 4

1

1

High-throughput

0.481

High

1398047

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

2

High-throughput

0.481

High

461823

HS90A
Heat shock protein HSP 90-alpha

1

1

High-throughput

0.479

High

468697

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

861730

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

2

Small-scale

0.479

High

180574

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.460

High

220796

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

0

High-throughput

0.460

High

681485

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.460

High

1086289

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.460

High

1230207

K1C40
Keratin, type I cytoskeletal 40

1

0

High-throughput

0.460

High

807537

IF4A3
Eukaryotic initiation factor 4A-III

1

0

High-throughput

0.458

High

986643

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1398050

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

1

High-throughput

0.439

High

1255115

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

848166

MAGA1
Melanoma-associated antigen 1

3

0

High-throughput

0.347

High

1239409

IIGP5
Interferon-inducible GTPase 5

2

0

High-throughput

0.328

High

1248573

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.328

High

1398044

TBL1Y
F-box-like/WD repeat-containing protein TBL1Y

2

0

High-throughput

0.328

High

1336447

PNMA1
Paraneoplastic antigen Ma1

2

0

High-throughput

0.304

High

1398042

MDFI
MyoD family inhibitor

2

0

High-throughput

0.304

High

1328111

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.279

Low

1100635

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.269

Low

1155672

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.269

Low

965830

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

0

High-throughput

0.251

Low

1063537

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.251

Low

1116564

FHL3
Four and a half LIM domains protein 3

1

0

High-throughput

0.251

Low

1205940

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

0

High-throughput

0.251

Low

1277360

NT2NA
Notch homolog 2 N-terminal-like protein A

1

0

High-throughput

0.251

Low

260318

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

372868

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

412451

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

521867

H14
Histone H1.4

1

0

High-throughput

0.249

Low

696248

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

716046

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

0

High-throughput

0.249

Low

1194757

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

1

0

Small-scale

0.249

Low

1398048

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025