Protein: LYPD4
Ly6/PLAUR domain-containing protein 4

Gene: LYPD4
Organism: Homo sapiens
Interactions: 122
UniProt ID: Q6UWN0

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0044853 - plasma membrane raft
GO:0098552 - side of membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

222375

TSN6
Tetraspanin-6

2

2

High-throughput

0.628

High

337267

ATS2
A disintegrin and metalloproteinase with thrombospondin motifs 2

2

1

High-throughput

0.628

High

772319

FBN2
Fibrillin-2 [Cleaved into: Placensin]

2

1

High-throughput

0.628

High

868976

NPTX2
Neuronal pentraxin-2

2

2

High-throughput

0.628

High

996993

TBA4A
Tubulin alpha-4A chain

2

1

High-throughput

0.628

High

756558

GALNS
N-acetylgalactosamine-6-sulfatase

2

0

High-throughput

0.602

High

1177225

MICA
MHC class I polypeptide-related sequence A

2

0

High-throughput

0.602

High

1248568

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

0

High-throughput

0.602

High

1248576

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

2

0

High-throughput

0.602

High

155858

DPYL4
Dihydropyrimidinase-related protein 4

2

1

High-throughput

0.574

High

1154238

NPTX1
Neuronal pentraxin-1

2

2

High-throughput

0.574

High

1248562

PGLT1
Protein O-glucosyltransferase 1

2

1

High-throughput

0.574

High

1248565

KI18A
Kinesin-like protein KIF18A

2

1

High-throughput

0.574

High

1248577

TCAB1
Telomerase Cajal body protein 1

2

4

High-throughput

0.574

High

375640

RASK
GTPase KRas

1

10

High-throughput

0.541

High

144054

MA2B1
Lysosomal alpha-mannosidase

1

1

High-throughput

0.536

High

161727

APAF
Apoptotic protease-activating factor 1

1

3

High-throughput

0.536

High

211926

SPIT1
Kunitz-type protease inhibitor 1

1

2

High-throughput

0.536

High

422378

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.536

High

464453

TSP1
Thrombospondin-1

1

3

High-throughput

0.536

High

472186

TRFM
Melanotransferrin

1

1

High-throughput

0.536

High

535206

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

551867

CO6A2

1

2

High-throughput

0.536

High

562733

BMP1
Bone morphogenetic protein 1

1

1

High-throughput

0.536

High

648561

FGFR4
Fibroblast growth factor receptor 4

1

1

High-throughput

0.536

High

650242

FGFR3
Fibroblast growth factor receptor 3

1

1

High-throughput

0.536

High

907914

PLXA3
Plexin-A3

1

1

High-throughput

0.536

High

937405

LAMB2
Laminin subunit beta-2

1

1

High-throughput

0.536

High

1055325

APLP2
Amyloid beta precursor like protein 2

1

2

High-throughput

0.536

High

1105809

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

2

High-throughput

0.536

High

1116997

LAMB3
Laminin subunit beta-3

1

1

High-throughput

0.536

High

1217412

OBSCN
Obscurin

1

1

High-throughput

0.536

High

1248559

VWDE
von Willebrand factor D and EGF domain-containing protein

1

1

High-throughput

0.536

High

1248563

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

1

High-throughput

0.536

High

1248584

SEM6B
Semaphorin-6B

1

1

High-throughput

0.536

High

1248594

ATS7
A disintegrin and metalloproteinase with thrombospondin motifs 7

1

1

High-throughput

0.536

High

1248598

JAG2
Protein jagged-2

1

1

High-throughput

0.536

High

1248601

ST14
Suppressor of tumorigenicity 14 protein

1

1

High-throughput

0.536

High

135952

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

0

High-throughput

0.513

High

896400

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.513

High

1060453

DPOE1
DNA polymerase epsilon catalytic subunit A

1

0

High-throughput

0.513

High

1089108

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.513

High

1104550

MSLN
Mesothelin

1

0

High-throughput

0.513

High

1127570

FAT1
Protocadherin Fat 1

1

0

High-throughput

0.513

High

1248569

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.513

High

1248570

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.513

High

1248574

LGMN
Legumain

1

0

High-throughput

0.513

High

1248575

HAUS7
HAUS augmin-like complex subunit 7

1

0

High-throughput

0.513

High

1248593

GAK1A
Golgi-associated kinase 1A

1

0

High-throughput

0.513

High

1248596

PPT2
Lysosomal thioesterase PPT2

1

0

High-throughput

0.513

High

62968

POTEF
POTE ankyrin domain family member F

1

3

High-throughput

0.489

High

566717

PDIA4
Protein disulfide-isomerase A4

1

1

High-throughput

0.489

High

698785

CALX
Calnexin

1

1

High-throughput

0.489

High

914092

HXK2
Hexokinase-2

1

1

High-throughput

0.489

High

1022407

IDD
Integral membrane protein DGCR2/IDD

1

2

High-throughput

0.489

High

1248326

PLGT2
Protein O-glucosyltransferase 2

1

1

High-throughput

0.489

High

1248549

CREL2
Protein disulfide isomerase CRELD2

1

1

High-throughput

0.489

High

1248550

ACD11
Acyl-CoA dehydrogenase family member 11

1

3

High-throughput

0.489

High

1248595

DD19B
ATP-dependent RNA helicase DDX19B

1

1

High-throughput

0.489

High

1248597

CE164
Centrosomal protein of 164 kDa

1

3

High-throughput

0.489

High

1248599

MA2B2
Epididymis-specific alpha-mannosidase

1

1

High-throughput

0.489

High

1248587

SEM4B
Semaphorin-4B

1

1

High-throughput

0.445

High

212879

AP5Z1
AP-5 complex subunit zeta-1

2

0

High-throughput

0.328

High

335391

GDF11
Growth/differentiation factor 11

2

0

High-throughput

0.328

High

339169

TYDP2
Tyrosyl-DNA phosphodiesterase 2

2

0

High-throughput

0.328

High

922541

AP3M2
AP-3 complex subunit mu-2

2

0

High-throughput

0.328

High

1081182

ELP6
Elongator complex protein 6

2

0

High-throughput

0.328

High

1085080

KIF1A
Kinesin-like protein KIF1A

2

0

High-throughput

0.328

High

1086505

TROAP
Tastin

2

0

High-throughput

0.328

High

1091885

NPRL3
GATOR1 complex protein NPRL3

2

0

High-throughput

0.328

High

1129552

ESPL1
Separin

2

0

High-throughput

0.328

High

1149309

STIL
SCL-interrupting locus protein

2

0

High-throughput

0.328

High

1193196

OFUT4
GDP-fucose protein O-fucosyltransferase 4

2

0

High-throughput

0.328

High

1206980

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

2

0

High-throughput

0.328

High

1214091

DIK1A
Divergent protein kinase domain 1A

2

0

High-throughput

0.328

High

1233981

ASPH2
Aspartate beta-hydroxylase domain-containing protein 2

2

0

High-throughput

0.328

High

1244401

BORA
Protein aurora borealis

2

0

High-throughput

0.328

High

1248551

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

2

0

High-throughput

0.328

High

1248553

VP13B
Intermembrane lipid transfer protein VPS13B

2

0

High-throughput

0.328

High

1248555

OAF
Out at first protein homolog

2

0

High-throughput

0.328

High

1248557

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

2

0

High-throughput

0.328

High

1248558

TRM44
Probable tRNA

2

0

High-throughput

0.328

High

1248564

SMG8
Nonsense-mediated mRNA decay factor SMG8

2

0

High-throughput

0.328

High

1248567

N42L2
NEDD4-binding protein 2-like 2

2

0

High-throughput

0.328

High

1248571

LMLN
Leishmanolysin-like peptidase

2

0

High-throughput

0.328

High

1248572

ANM6
Protein arginine N-methyltransferase 6

2

0

High-throughput

0.328

High

1248573

FXL18
F-box/LRR-repeat protein 18

2

0

High-throughput

0.328

High

1248578

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

2

0

High-throughput

0.328

High

1248580

FANCJ
Fanconi anemia group J protein

2

0

High-throughput

0.328

High

1248581

GRB1L
GREB1-like protein

2

0

High-throughput

0.328

High

1248582

XYLT2
Xylosyltransferase 2

2

0

High-throughput

0.328

High

1248583

VPS16
Vacuolar protein sorting-associated protein 16 homolog

2

0

High-throughput

0.328

High

1248585

TOR3A
Torsin-3A

2

0

High-throughput

0.328

High

1248586

JMJD4
2-oxoglutarate and iron-dependent oxygenase JMJD4

2

0

High-throughput

0.328

High

1248589

PANK4
4'-phosphopantetheine phosphatase

2

0

High-throughput

0.328

High

1248591

VPS18
Vacuolar protein sorting-associated protein 18 homolog

2

0

High-throughput

0.328

High

1248592

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

2

0

High-throughput

0.328

High

159001

ZN195
Zinc finger protein 195

1

0

High-throughput

0.279

Low

183154

GNPAT
Dihydroxyacetone phosphate acyltransferase

1

0

High-throughput

0.279

Low

282599

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

High-throughput

0.279

Low

329292

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.279

Low

351123

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.279

Low

600616

NAGAB
Alpha-N-acetylgalactosaminidase

1

0

High-throughput

0.279

Low

870649

MAOX
NADP-dependent malic enzyme

1

0

High-throughput

0.279

Low

873402

LSS
Lanosterol synthase

1

0

High-throughput

0.279

Low

932374

ANAG
Alpha-N-acetylglucosaminidase

1

0

High-throughput

0.279

Low

1067019

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

1

0

High-throughput

0.279

Low

1128753

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.279

Low

1243810

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

High-throughput

0.279

Low

1245034

TRI65
E3 ubiquitin-protein ligase TRIM65

1

0

High-throughput

0.279

Low

1248552

MYCPP
C-myc promoter-binding protein

1

0

High-throughput

0.279

Low

1248554

ADCK1
AarF domain-containing protein kinase 1

1

0

High-throughput

0.279

Low

1248556

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.279

Low

1248560

BANP
Protein BANP

1

0

High-throughput

0.279

Low

1248561

SUMF1
Formylglycine-generating enzyme

1

0

High-throughput

0.279

Low

1248566

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

0

High-throughput

0.279

Low

1248579

PRR14
Proline-rich protein 14

1

0

High-throughput

0.279

Low

1248588

TF7L2
Transcription factor 7-like 2

1

0

High-throughput

0.279

Low

1248590

UCKL1
Uridine-cytidine kinase-like 1

1

0

High-throughput

0.279

Low

1248600

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.279

Low

1248602

S23IP
SEC23-interacting protein

1

0

High-throughput

0.279

Low

157524

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025