Protein: DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial (EC 1.1.1.-) (Dicarbonyl reductase HEP27) (Protein D) (Short chain dehydrogenase/reductase family 25C member 1) (Protein SDR25C1)

Gene: DHRS2
Organism: Homo sapiens
Interactions: 92
UniProt ID: Q13268

Gene Ontology (top 5):
GO:0004090 - carbonyl reductase (NADPH) activity
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

591293

CD44
CD44 antigen

2

1

High-throughput

0.628

High

616751

SDC1
Syndecan-1

3

4

High-throughput

0.604

High

1100652

GMEB1
Glucocorticoid modulatory element-binding protein 1

2

0

High-throughput

0.602

High

829375

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

2

3

High-throughput

0.601

High

760436

SDC2
Syndecan-2

2

4

High-throughput

0.574

High

396038

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

563715

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.571

High

999346

HBB
Hemoglobin subunit beta

2

1

High-throughput

0.549

High

1100627

APBP2
Amyloid protein-binding protein 2

1

0

High-throughput

0.549

High

704468

MZF1
Myeloid zinc finger 1

1

1

High-throughput

0.536

High

725602

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

2

High-throughput

0.536

High

856257

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.536

High

1100608

PPCEL
Prolyl endopeptidase-like

1

1

High-throughput

0.536

High

1100637

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

1

High-throughput

0.536

High

1100642

SYTM
Threonine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

1100603

TCEA2
Transcription elongation factor A protein 2

1

0

High-throughput

0.518

High

1100646

EXOS5
Exosome complex component RRP46

1

0

High-throughput

0.518

High

1100654

ZHX2
Zinc fingers and homeoboxes protein 2

1

0

High-throughput

0.518

High

1100638

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.515

High

162827

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

0

High-throughput

0.513

High

882473

ARRB1
Beta-arrestin-1

1

0

High-throughput

0.513

High

926656

HIRA
Protein HIRA

1

0

High-throughput

0.513

High

1100609

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.513

High

1100633

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

0

High-throughput

0.513

High

1100634

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.513

High

1100636

PASK
PAS domain-containing serine/threonine-protein kinase

1

0

High-throughput

0.513

High

1100648

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.513

High

163758

TCRG1
Transcription elongation regulator 1

1

0

High-throughput

0.493

High

457861

INVO
Involucrin

1

0

High-throughput

0.493

High

519502

MYBB
Myb-related protein B

1

0

High-throughput

0.493

High

942027

PER3
Period circadian protein homolog 3

1

0

High-throughput

0.493

High

1100602

SAFB2
Scaffold attachment factor B2

1

0

High-throughput

0.493

High

1100606

CCD14
Coiled-coil domain-containing protein 14

1

0

High-throughput

0.493

High

1100611

AMERL
AMMECR1-like protein

1

0

High-throughput

0.493

High

1100614

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.493

High

1100615

CC141
Coiled-coil domain-containing protein 141

1

0

High-throughput

0.493

High

1100630

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

1

0

High-throughput

0.493

High

1100631

STMN2
Stathmin-2

1

0

High-throughput

0.493

High

1100640

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.493

High

718392

CD6
T-cell differentiation antigen CD6

1

1

High-throughput

0.489

High

726659

SDC4
Syndecan-4

1

4

High-throughput

0.489

High

1100650

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

276122

NIPS2
Protein NipSnap homolog 2

1

1

Small-scale

0.479

High

363221

EGFR
Epidermal growth factor receptor

1

1

Small-scale

0.479

High

371935

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

400770

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

623318

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

948523

APC15
Anaphase-promoting complex subunit 15

1

1

High-throughput

0.479

High

1100604

RBBP7
Histone-binding protein RBBP7

1

2

High-throughput

0.479

High

1100605

SMU1
WD40 repeat-containing protein SMU1

1

1

High-throughput

0.479

High

1100619

HDGR2
Hepatoma-derived growth factor-related protein 2

1

1

High-throughput

0.479

High

1100622

COP1
E3 ubiquitin-protein ligase COP1

1

2

High-throughput

0.479

High

1100628

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1100645

WDR76
WD repeat-containing protein 76

1

3

High-throughput

0.479

High

1100649

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1100651

PPME1
Protein phosphatase methylesterase 1

1

1

Small-scale

0.479

High

1100653

TACC3
Transforming acidic coiled-coil-containing protein 3

1

2

High-throughput

0.479

High

1100639

MA7D2
MAP7 domain-containing protein 2

1

1

High-throughput

0.470

High

71009

ZN724
Zinc finger protein 724

1

0

High-throughput

0.458

High

132008

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

159637

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

241579

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

345757

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

504890

H2AB2
Histone H2A-Bbd type 2/3

1

0

High-throughput

0.458

High

888027

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

898228

R144A
E3 ubiquitin-protein ligase RNF144A

1

0

Small-scale

0.458

High

984098

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.458

High

1028179

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

1100612

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.458

High

1100613

CDC73
Parafibromin

1

0

High-throughput

0.458

High

1100617

DET1
DET1 homolog

1

0

High-throughput

0.458

High

1100624

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1100629

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.458

High

1100632

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1100641

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1100643

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

999633

HBA
Hemoglobin subunit alpha

1

1

High-throughput

0.437

High

1100610

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

1100620

TEFF1
Tomoregulin-1

3

0

High-throughput

0.347

High

1100626

AP3S1
AP-3 complex subunit sigma-1

2

0

High-throughput

0.328

High

1100618

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

159108

ENPP3
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

1

0

High-throughput

0.269

Low

572396

SUIS
Sucrase-isomaltase, intestinal [Cleaved into: Sucrase

1

0

High-throughput

0.269

Low

1100621

PHTF2
Protein PHTF2

1

0

High-throughput

0.269

Low

1100623

DYH3
Dynein axonemal heavy chain 3

1

0

High-throughput

0.269

Low

1100635

FXL18
F-box/LRR-repeat protein 18

1

0

High-throughput

0.269

Low

1100644

ELOV4
Very long chain fatty acid elongase 4

1

0

High-throughput

0.269

Low

1100647

TRM13
tRNA:m(4)X modification enzyme TRM13 homolog

1

0

High-throughput

0.269

Low

378859

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.249

Low

1100607

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

0

Small-scale

0.249

Low

1100616

ASB18
Ankyrin repeat and SOCS box protein 18

1

0

High-throughput

0.249

Low

1100625

ASB15
Ankyrin repeat and SOCS box protein 15

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025