Protein: PAXX
Protein PAXX (Paralog of XRCC4 and XLF) (XRCC4-like small protein)

Gene: PAXX
Organism: Homo sapiens
Interactions: 40
UniProt ID: Q9BUH6

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0006303 - double-strand break repair via nonhomologous end joining
GO:0006974 - DNA damage response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

558376

XRCC6
X-ray repair cross-complementing protein 6

4

1

Small-scale

0.895

High

559481

XRCC5
X-ray repair cross-complementing protein 5

3

1

Small-scale

0.848

High

1414252

PAXX
Protein PAXX

1

0

Small-scale

0.679

High

290979

PPM1B
Protein phosphatase 1B

3

0

High-throughput

0.634

High

1122954

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

2

0

High-throughput

0.576

High

1104931

XRCC4
DNA repair protein XRCC4

2

0

Small-scale

0.559

High

1008319

PRKDC
DNA-dependent protein kinase catalytic subunit

2

0

Small-scale

0.547

High

451634

GPX1
Glutathione peroxidase 1

1

1

High-throughput

0.536

High

939905

DLX6
Homeobox protein DLX-6

1

1

High-throughput

0.536

High

334316

TACC2
Transforming acidic coiled-coil-containing protein 2

1

0

High-throughput

0.513

High

801501

HSPA9
Stress-70 protein, mitochondrial

1

0

High-throughput

0.513

High

1045715

TF65
Transcription factor p65

1

0

High-throughput

0.513

High

1048228

EMX2
Homeobox protein EMX2

1

0

High-throughput

0.513

High

1253983

RBPS2
RNA-binding protein with multiple splicing 2

1

0

High-throughput

0.513

High

1272904

VASH1
Tubulinyl-Tyr carboxypeptidase 1

1

0

High-throughput

0.513

High

1407755

FOXB1
Forkhead box protein B1

1

0

High-throughput

0.513

High

1414255

ROP1A
Ropporin-1A

1

0

High-throughput

0.513

High

1414256

MA2C1
Alpha-mannosidase 2C1

1

0

High-throughput

0.513

High

1386555

OPTN
Optineurin

1

0

High-throughput

0.493

High

1402860

GPX7
Glutathione peroxidase 7

1

1

High-throughput

0.489

High

423039

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

955536

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

1141285

BRD3
Bromodomain-containing protein 3

1

0

High-throughput

0.458

High

1255324

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1338344

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1414253

CYREN
Cell cycle regulator of non-homologous end joining

1

0

Small-scale

0.458

High

892725

DNLI4
DNA ligase 4

1

0

Small-scale

0.426

High

1199892

AKIR2
Akirin-2

1

0

High-throughput

0.426

High

602904

INAR1
Interferon alpha/beta receptor 1

1

0

High-throughput

0.279

Low

658553

GCSH
Glycine cleavage system H protein, mitochondrial

1

0

High-throughput

0.279

Low

706287

S10A2
Protein S100-A2

1

0

High-throughput

0.279

Low

1329546

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.279

Low

1348950

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

136971

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.249

Low

1041695

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

Small-scale

0.249

Low

517309

GAGE1
G antigen 1

1

0

High-throughput

0.232

Low

948925

CD81
CD81 antigen

1

0

Small-scale

0.232

Low

1275825

RM21
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.232

Low

1414254

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025