Protein: RM21
Large ribosomal subunit protein bL21m (39S ribosomal protein L21, mitochondrial) (L21mt) (MRP-L21)

Gene: RM21, MRPL21
Organism: Homo sapiens
Interactions: 175
UniProt ID: Q7Z2W9

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003735 - structural constituent of ribosome
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005762 - mitochondrial large ribosomal subunit

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1275828

RM20
Large ribosomal subunit protein bL20m

2

1

High-throughput

0.811

High

1275874

RM42
Large ribosomal subunit protein mL42

3

0

High-throughput

0.811

High

1275791

RM52
Large ribosomal subunit protein mL52

2

0

High-throughput

0.736

High

1275831

RM04
Large ribosomal subunit protein uL4m

4

1

High-throughput

0.694

High

856301

IF2M
Translation initiation factor IF-2, mitochondrial

4

2

High-throughput

0.691

High

1275798

RM50
Large ribosomal subunit protein mL50

4

0

High-throughput

0.670

High

1275846

RM47
Large ribosomal subunit protein uL29m

3

1

High-throughput

0.667

High

1275847

RT30
Large ribosomal subunit protein mL65

4

0

High-throughput

0.661

High

1117767

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

3

1

High-throughput

0.656

High

1275829

RM13
Large ribosomal subunit protein uL13m

3

2

High-throughput

0.650

High

1275862

RM27
Large ribosomal subunit protein bL27m

3

1

High-throughput

0.650

High

1087437

GRSF1
G-rich sequence factor 1

3

1

Small-scale

0.640

High

1275790

RM10
Large ribosomal subunit protein uL10m

3

0

High-throughput

0.634

High

649893

ADRO
NADPH:adrenodoxin oxidoreductase, mitochondrial

2

1

High-throughput

0.628

High

994623

YBOX1
Y-box-binding protein 1

2

4

High-throughput

0.628

High

1106432

TOP3A
DNA topoisomerase 3-alpha

2

1

High-throughput

0.628

High

1138852

SYLM
Leucine--tRNA ligase, mitochondrial

2

1

High-throughput

0.628

High

1275795

GTPB8
GTP-binding protein 8

2

3

High-throughput

0.628

High

1275860

RM39
Large ribosomal subunit protein mL39

3

0

High-throughput

0.628

High

1275836

RM18
Large ribosomal subunit protein uL18m

3

0

High-throughput

0.622

High

1275819

EFGM
Elongation factor G, mitochondrial

2

1

High-throughput

0.611

High

1275844

RM44
Large ribosomal subunit protein mL44

2

1

High-throughput

0.611

High

884660

SYHM
Histidine--tRNA ligase, mitochondrial

2

0

High-throughput

0.602

High

1216261

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

2

0

High-throughput

0.602

High

1272305

NDUF7
Protein arginine methyltransferase NDUFAF7, mitochondrial

2

0

High-throughput

0.602

High

1275821

RNZ2
Zinc phosphodiesterase ELAC protein 2

2

0

High-throughput

0.602

High

1275851

SYIM
Isoleucine--tRNA ligase, mitochondrial

2

0

High-throughput

0.602

High

914650

RM12
Large ribosomal subunit protein bL12m

2

1

High-throughput

0.601

High

1213275

RM02
Large ribosomal subunit protein uL2m

2

1

High-throughput

0.601

High

1275869

YBOX2
Y-box-binding protein 2

2

4

High-throughput

0.601

High

979029

RS6
Small ribosomal subunit protein eS6

3

0

High-throughput

0.597

High

969283

RS8
Small ribosomal subunit protein eS8

2

0

High-throughput

0.585

High

1275802

RM30
Large ribosomal subunit protein uL30m

2

0

High-throughput

0.585

High

1162394

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

1196116

RM51
Large ribosomal subunit protein mL51

2

0

High-throughput

0.576

High

1275793

RM41
Large ribosomal subunit protein mL41

2

0

High-throughput

0.576

High

279814

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

1058106

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

2

0

Small-scale

0.559

High

1275863

MRES1
Mitochondrial transcription rescue factor 1

2

0

High-throughput

0.559

High

1123332

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.547

High

229146

GTPB6
Putative GTP-binding protein 6

1

4

High-throughput

0.536

High

824209

RL13A
Large ribosomal subunit protein uL13

1

2

High-throughput

0.536

High

1275799

RM43
Large ribosomal subunit protein mL43

1

1

High-throughput

0.536

High

1275804

GTPB3
5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial

1

3

High-throughput

0.536

High

1275808

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

1

High-throughput

0.536

High

1275832

RM01
Large ribosomal subunit protein uL1m

1

1

High-throughput

0.536

High

1275845

LN28A
Protein lin-28 homolog A

1

4

High-throughput

0.536

High

447160

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

725623

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

0

High-throughput

0.513

High

860254

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.513

High

964124

RL37
Large ribosomal subunit protein eL37

1

0

High-throughput

0.513

High

1016076

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

1016492

SRSF3
Serine/arginine-rich splicing factor 3

1

0

High-throughput

0.513

High

1027552

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.513

High

1148710

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

0

High-throughput

0.513

High

1158232

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.513

High

1194829

PPCEL
Prolyl endopeptidase-like

1

0

High-throughput

0.513

High

1244549

SYDM
Aspartate--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1275796

PTGR3
Prostaglandin reductase 3

1

0

High-throughput

0.513

High

1275801

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.513

High

1275814

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1275815

RM53
Large ribosomal subunit protein mL53

1

0

High-throughput

0.513

High

1275830

RM09
Large ribosomal subunit protein bL9m

1

0

High-throughput

0.513

High

1275834

RM37
Large ribosomal subunit protein mL37

1

0

High-throughput

0.513

High

1275867

ZN346
Zinc finger protein 346

1

0

High-throughput

0.513

High

1275873

PUS1
Pseudouridylate synthase 1 homolog

1

0

High-throughput

0.513

High

508196

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

281992

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

287320

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

350913

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

786152

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

988146

TRA2B
Transformer-2 protein homolog beta

1

1

High-throughput

0.479

High

1083654

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

1094047

RM28
Large ribosomal subunit protein bL28m

1

1

High-throughput

0.479

High

1111801

TRA2A
Transformer-2 protein homolog alpha

1

1

High-throughput

0.479

High

1135899

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

3

High-throughput

0.479

High

1234432

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

1272924

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

3

High-throughput

0.479

High

1275803

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

1

High-throughput

0.479

High

1275805

FAKD4
FAST kinase domain-containing protein 4

1

3

High-throughput

0.479

High

1275807

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

1275809

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

1275811

RM38
Large ribosomal subunit protein mL38

1

1

High-throughput

0.479

High

1275839

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

1275850

RM17
Large ribosomal subunit protein bL17m

1

2

High-throughput

0.479

High

1275852

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.479

High

1275858

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

1

High-throughput

0.479

High

1275861

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.479

High

1275864

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

1275870

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.479

High

1275872

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.479

High

61538

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

66225

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

75988

B4DEF8
Large ribosomal subunit protein mL45

1

0

High-throughput

0.458

High

183673

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

275982

DUS11
RNA/RNP complex-1-interacting phosphatase

1

0

High-throughput

0.458

High

472851

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

485230

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

532712

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

559999

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

828829

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

841811

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

851936

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

882332

RM19
Large ribosomal subunit protein bL19m

1

0

High-throughput

0.458

High

882750

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

1024087

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1048576

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1092167

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

1104001

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.458

High

1142585

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1149588

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

1194182

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

1241308

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

1270572

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

1271434

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.458

High

1275527

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

0

High-throughput

0.458

High

1275792

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.458

High

1275806

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1275810

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

0

High-throughput

0.458

High

1275812

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1275813

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1275816

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.458

High

1275818

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

1275820

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

1275822

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1275823

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

1275824

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

1275826

TR61B
tRNA

1

0

High-throughput

0.458

High

1275827

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1275833

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1275835

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1275837

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1275838

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

1275840

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

1275842

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1275843

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1275848

NGRN
Neugrin

1

0

High-throughput

0.458

High

1275853

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1275855

RT18A
Large ribosomal subunit protein mL66

1

0

High-throughput

0.458

High

1275856

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

1275857

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1275859

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

High-throughput

0.458

High

1275871

FBX7
F-box only protein 7

1

0

High-throughput

0.458

High

1214717

ATD3B
ATPase family AAA domain-containing protein 3B

1

1

High-throughput

0.445

High

1275854

ATD3A
ATPase family AAA domain-containing protein 3A

1

2

High-throughput

0.445

High

372409

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

406324

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

653404

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

810185

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.426

High

1209320

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

76597

B4DYI6
cDNA FLJ60196, highly similar to Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.407

High

1275800

NBEA
Neurobeachin

2

0

High-throughput

0.328

High

169255

CASQ2
Calsequestrin-2

2

0

High-throughput

0.318

High

1260361

H1FNT
Testis-specific H1 histone

2

0

High-throughput

0.313

High

890849

TSC2
Tuberin

1

0

High-throughput

0.282

High

800425

LICH
Lysosomal acid lipase/cholesteryl ester hydrolase

1

0

High-throughput

0.279

Low

945712

FOXL2
Forkhead box protein L2

1

0

High-throughput

0.279

Low

1113524

CUL3
Cullin-3

1

0

High-throughput

0.279

Low

1275817

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.279

Low

1042887

ERCC6
DNA excision repair protein ERCC-6

1

0

High-throughput

0.261

Low

1275866

KLF15
Krueppel-like factor 15

1

0

High-throughput

0.261

Low

315731

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

589020

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

830974

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

1015552

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.249

Low

1095684

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.249

Low

1254400

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1275789

FBX33
F-box only protein 33

1

0

High-throughput

0.249

Low

1275794

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.249

Low

1275797

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1275841

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1275849

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

1275865

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1275868

FBW1A
F-box/WD repeat-containing protein 1A

1

0

High-throughput

0.249

Low

1275825

PAXX
Protein PAXX

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025