Protein: M3K8
Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2)

Gene: M3K8, MAP3K8
Organism: Homo sapiens
Interactions: 41
UniProt ID: P41279

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

587460

NFKB1
Nuclear factor NF-kappa-B p105 subunit

10

13

Small-scale

0.982

High

783311

M3K8
Mitogen-activated protein kinase kinase kinase 8

3

17

Small-scale

0.840

High

783317

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

3

18

Small-scale

0.840

High

783315

NFKB2
Nuclear factor NF-kappa-B p100 subunit

2

12

High-throughput

0.802

High

437961

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.776

High

431620

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.754

High

167492

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.747

High

783326

TNIP2
TNFAIP3-interacting protein 2

5

1

Small-scale

0.727

High

681711

AKT1
RAC-alpha serine/threonine-protein kinase

1

16

Small-scale

0.724

High

783318

TF65
Transcription factor p65

4

9

Small-scale

0.702

High

783325

KSR2
Kinase suppressor of Ras 2

1

20

Small-scale

0.665

High

783328

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

17

Small-scale

0.665

High

783312

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

17

Small-scale

0.647

High

783324

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

17

Small-scale

0.618

High

783323

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.594

High

331457

ACL6A
Actin-like protein 6A

1

6

High-throughput

0.553

High

575316

EGR1
Early growth response protein 1

1

5

High-throughput

0.553

High

684478

STIP1
Stress-induced-phosphoprotein 1

1

9

High-throughput

0.541

High

783327

ACY3
N-acyl-aromatic-L-amino acid amidohydrolase

1

0

High-throughput

0.518

High

783319

REL
Proto-oncogene c-Rel

1

10

High-throughput

0.515

High

162469

XPO1
Exportin-1

1

6

High-throughput

0.479

High

381141

TBB4A
Tubulin beta-4A chain

1

16

High-throughput

0.479

High

428068

TBB5
Tubulin beta chain

1

17

High-throughput

0.479

High

501788

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

503599

HSP7C
Heat shock cognate 71 kDa protein

1

16

High-throughput

0.479

High

571686

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

3

High-throughput

0.479

High

713919

HS71L
Heat shock 70 kDa protein 1-like

1

16

High-throughput

0.479

High

751517

GRP75
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

783314

CLH1
Clathrin heavy chain 1

1

3

High-throughput

0.479

High

783316

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

3

High-throughput

0.479

High

783322

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

783329

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

1

Small-scale

0.479

High

783330

Q9UQC1
Heat shock protein 72

1

20

High-throughput

0.479

High

783331

RUVB1
RuvB-like 1

1

3

High-throughput

0.479

High

783332

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

551631

DESP
Desmoplakin

1

20

High-throughput

0.437

High

639557

TNR5
Tumor necrosis factor receptor superfamily member 5

1

6

Small-scale

0.437

High

783313

EPIPL
Epiplakin

1

10

High-throughput

0.437

High

783320

EF1A2
Elongation factor 1-alpha 2

1

5

High-throughput

0.437

High

783321

LG3BP
Galectin-3-binding protein

1

5

High-throughput

0.437

High


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024