Protein: MARK3
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)

Gene: MARK3
Organism: Homo sapiens
Interactions: 243
UniProt ID: P27448

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

507541

PIM1
Serine/threonine-protein kinase pim-1

5

16

Small-scale

0.933

High

647834

MPIP3
M-phase inducer phosphatase 3

4

3

Small-scale

0.904

High

349893

RASK
GTPase KRas

4

13

High-throughput

0.873

High

647915

MARK2
Serine/threonine-protein kinase MARK2

3

17

High-throughput

0.867

High

647923

KSR1
Kinase suppressor of Ras 1

3

9

Small-scale

0.861

High

647828

MARK3
MAP/microtubule affinity-regulating kinase 3

3

15

Small-scale

0.840

High

348523

RASN
GTPase NRas

3

13

High-throughput

0.827

High

647922

LRC33
Transforming growth factor beta activator LRRC33

2

1

High-throughput

0.811

High

647947

MARK4
MAP/microtubule affinity-regulating kinase 4

2

16

High-throughput

0.811

High

647954

NUAK2
NUAK family SNF1-like kinase 2

2

17

High-throughput

0.811

High

648000

CERT
Ceramide transfer protein

2

3

High-throughput

0.811

High

647869

1433Z
14-3-3 protein zeta/delta

15

20

Small-scale

0.764

High

647835

1433B
14-3-3 protein beta/alpha

12

20

Small-scale

0.760

High

647860

1433G
14-3-3 protein gamma

11

20

Small-scale

0.757

High

647879

1433F
14-3-3 protein eta

11

20

Small-scale

0.757

High

646650

1433T
14-3-3 protein theta

10

20

Small-scale

0.756

High

349139

RASH
GTPase HRas

2

8

High-throughput

0.754

High

373716

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

8

High-throughput

0.754

High

647867

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

647862

1433E
14-3-3 protein epsilon

9

18

Small-scale

0.752

High

647836

1433S
14-3-3 protein sigma

4

20

High-throughput

0.697

High

161966

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

1

High-throughput

0.691

High

647851

DAPK1
Death-associated protein kinase 1

1

11

High-throughput

0.691

High

647884

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.691

High

647888

AVR2B
Activin receptor type-2B

1

4

High-throughput

0.691

High

647920

THOC4
THO complex subunit 4

1

1

High-throughput

0.691

High

647953

PDIP3
Polymerase delta-interacting protein 3

1

1

High-throughput

0.691

High

647983

G3BP2
Ras GTPase-activating protein-binding protein 2

1

3

High-throughput

0.691

High

647990

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

11

High-throughput

0.691

High

647890

RGRF1
Ras-specific guanine nucleotide-releasing factor 1

1

0

Small-scale

0.687

High

647932

ASB13
Ankyrin repeat and SOCS box protein 13

1

3

High-throughput

0.683

High

239795

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

7

High-throughput

0.646

High

647940

ARHG2
Rho guanine nucleotide exchange factor 2

2

3

Small-scale

0.646

High

254549

CLAP2
CLIP-associating protein 2

2

4

Small-scale

0.639

High

159702

CASQ2
Calsequestrin-2

3

0

High-throughput

0.638

High

301264

MTCL2
Microtubule cross-linking factor 2

2

10

High-throughput

0.628

High

647843

CAPZB
F-actin-capping protein subunit beta

2

1

High-throughput

0.628

High

647929

DLG5
Disks large homolog 5

2

2

High-throughput

0.628

High

647995

MTCL1
Microtubule cross-linking factor 1

2

10

High-throughput

0.628

High

71073

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

2

High-throughput

0.618

High

120307

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

158401

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

18

Small-scale

0.618

High

176122

PPM1G
Protein phosphatase 1G

1

3

Small-scale

0.618

High

226582

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.618

High

273369

PPM1B
Protein phosphatase 1B

1

5

Small-scale

0.618

High

318068

DIRA3
GTP-binding protein Di-Ras3

1

3

High-throughput

0.618

High

384307

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.618

High

411606

LCK
Tyrosine-protein kinase Lck

1

7

High-throughput

0.618

High

433589

LYN
Tyrosine-protein kinase Lyn

1

7

High-throughput

0.618

High

436165

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

507867

FGFR1
Fibroblast growth factor receptor 1

1

5

High-throughput

0.618

High

545213

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

564418

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

568551

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

13

High-throughput

0.618

High

592109

RAB5A
Ras-related protein Rab-5A

1

6

High-throughput

0.618

High

600512

EPHA1
Ephrin type-A receptor 1

1

3

High-throughput

0.618

High

647831

EPHB2
Ephrin type-B receptor 2

1

7

High-throughput

0.618

High

647833

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

7

Small-scale

0.618

High

647841

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.618

High

647847

GSK3A
Glycogen synthase kinase-3 alpha

1

4

High-throughput

0.618

High

647848

RAB9A
Ras-related protein Rab-9A

1

8

High-throughput

0.618

High

647849

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

647852

AFAD
Afadin

1

6

High-throughput

0.618

High

647855

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

647856

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

647857

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.618

High

647858

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

647859

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

647861

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.618

High

647864

RB11A
Ras-related protein Rab-11A

1

2

High-throughput

0.618

High

647868

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

647871

CXAR
Coxsackievirus and adenovirus receptor

1

2

High-throughput

0.618

High

647872

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

647876

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

9

High-throughput

0.618

High

647878

KPCT
Protein kinase C theta type

1

10

Small-scale

0.618

High

647883

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

16

Small-scale

0.618

High

647885

SNTB2
Beta-2-syntrophin

1

7

High-throughput

0.618

High

647889

SNTB1
Beta-1-syntrophin

1

8

High-throughput

0.618

High

647896

RAB35
Ras-related protein Rab-35

1

4

High-throughput

0.618

High

647900

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

647902

NTRK2
BDNF/NT-3 growth factors receptor

1

10

High-throughput

0.618

High

647912

STYK1
Tyrosine-protein kinase STYK1

1

5

High-throughput

0.618

High

647914

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.618

High

647916

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

647936

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

647946

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

647957

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.618

High

647958

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

647959

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.618

High

647964

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

647970

ANLN
Anillin

1

2

High-throughput

0.618

High

647981

TPX2
Targeting protein for Xklp2

1

2

High-throughput

0.618

High

647984

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

1

High-throughput

0.618

High

647985

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

6

Small-scale

0.618

High

647842

UTRN
Utrophin

2

12

High-throughput

0.611

High

647975

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

2

7

Small-scale

0.601

High

647905

MIDN
Midnolin

1

0

High-throughput

0.586

High

647952

PKP2
Plakophilin-2

1

2

Small-scale

0.586

High

496358

TAU
Microtubule-associated protein tau

2

10

Small-scale

0.585

High

506883

LAMP1
Lysosome-associated membrane glycoprotein 1

2

5

High-throughput

0.584

High

563260

ZNF14
Zinc finger protein 14

1

0

High-throughput

0.578

High

647887

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

10

High-throughput

0.575

High

253835

TMCC2
Transmembrane and coiled-coil domains protein 2

2

1

High-throughput

0.574

High

369024

ESR1
Estrogen receptor

2

5

High-throughput

0.571

High

647918

CLAP1
CLIP-associating protein 1

1

4

Small-scale

0.561

High

647931

HDAC7
Histone deacetylase 7

1

9

Small-scale

0.561

High

647973

DNJ5B
DnaJ homolog subfamily C member 5B

1

4

High-throughput

0.553

High

647980

HECD1
E3 ubiquitin-protein ligase HECTD1

1

9

High-throughput

0.553

High

647840

GDE
Glycogen debranching enzyme

1

1

High-throughput

0.536

High

647845

SPB4
Serpin B4

1

1

High-throughput

0.536

High

647850

CAZA1
F-actin-capping protein subunit alpha-1

1

2

High-throughput

0.536

High

647866

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

6

High-throughput

0.536

High

647873

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.536

High

647880

AKP13
A-kinase anchor protein 13

1

7

High-throughput

0.536

High

647895

TEBP
Prostaglandin E synthase 3

1

4

High-throughput

0.536

High

647907

CE85L
Centrosomal protein of 85 kDa-like

1

8

High-throughput

0.536

High

647913

MACC1
Metastasis-associated in colon cancer protein 1

1

1

High-throughput

0.536

High

647927

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.536

High

647939

FGF13
Fibroblast growth factor 13

1

1

High-throughput

0.536

High

647948

TMM74
Transmembrane protein 74

1

1

High-throughput

0.536

High

647971

BCLF1
Bcl-2-associated transcription factor 1

1

1

High-throughput

0.536

High

647982

PCDGG
Protocadherin gamma-B4

1

3

High-throughput

0.536

High

647991

TR150
Thyroid hormone receptor-associated protein 3

1

1

High-throughput

0.536

High

647996

GPSM3
G-protein-signaling modulator 3

1

2

High-throughput

0.536

High

647934

ANKR7
Ankyrin repeat domain-containing protein 7

1

3

High-throughput

0.528

High

647898

TCEA2
Transcription elongation factor A protein 2

1

1

High-throughput

0.518

High

363567

TTHY
Transthyretin

1

0

High-throughput

0.518

High

647829

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.518

High

647942

PLPL2
Patatin-like phospholipase domain-containing protein 2

1

0

High-throughput

0.518

High

124767

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

High-throughput

0.513

High

647865

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

0

High-throughput

0.513

High

647893

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

647904

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.513

High

647926

TEX19
Testis-expressed protein 19

1

0

High-throughput

0.513

High

647933

DDX1
ATP-dependent RNA helicase DDX1

1

0

High-throughput

0.513

High

647935

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.513

High

647989

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.513

High

647993

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.513

High

647998

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

503266

MTAP2
Microtubule-associated protein 2

1

12

Small-scale

0.501

High

647994

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

647919

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

3

High-throughput

0.500

High

264844

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.494

High

647956

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

1

High-throughput

0.494

High

647854

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.489

High

647951

RSF1
Remodeling and spacing factor 1

1

7

High-throughput

0.489

High

647961

MANS1
MANSC domain-containing protein 1

1

2

High-throughput

0.489

High

647979

PNMA2
Paraneoplastic antigen Ma2

1

5

High-throughput

0.489

High

252905

MITF
Microphthalmia-associated transcription factor

1

1

Small-scale

0.481

High

48266

ESYT2
Extended synaptotagmin-2

1

2

High-throughput

0.479

High

116775

KIF2A
Kinesin-like protein KIF2A

1

3

Small-scale

0.479

High

150862

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

10

High-throughput

0.479

High

166211

GRRE1
Granule associated Rac and RHOG effector protein 1

1

3

High-throughput

0.479

High

178402

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

212743

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

246425

DTNB
Dystrobrevin beta

1

10

High-throughput

0.479

High

257161

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

4

High-throughput

0.479

High

279442

FLOT1
Flotillin-1

1

1

High-throughput

0.479

High

345337

FOS
Protein c-Fos

1

2

High-throughput

0.479

High

375806

FUCO
Tissue alpha-L-fucosidase

1

2

High-throughput

0.479

High

451639

CLCB
Clathrin light chain B

1

2

High-throughput

0.479

High

455113

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

483289

TPC2B
Trafficking protein particle complex subunit 2B

1

4

High-throughput

0.479

High

521738

CADH1
Cadherin-1

1

7

High-throughput

0.479

High

527307

LAMP2
Lysosome-associated membrane glycoprotein 2

1

5

High-throughput

0.479

High

546938

EZRI
Ezrin

1

4

High-throughput

0.479

High

566931

CXA1
Gap junction alpha-1 protein

1

5

High-throughput

0.479

High

576986

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

2

High-throughput

0.479

High

647832

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.479

High

647837

CTNA1
Catenin alpha-1

1

2

High-throughput

0.479

High

647844

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

647846

LMAN1
Protein ERGIC-53

1

1

High-throughput

0.479

High

647853

HDAC4
Histone deacetylase 4

1

9

Small-scale

0.479

High

647863

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.479

High

647870

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

5

Small-scale

0.479

High

647874

VIGLN
Vigilin

1

2

High-throughput

0.479

High

647877

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

647881

STX4
Syntaxin-4

1

4

High-throughput

0.479

High

647882

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

4

Small-scale

0.479

High

647886

STIM1
Stromal interaction molecule 1

1

4

High-throughput

0.479

High

647891

CKAP5
Cytoskeleton-associated protein 5

1

12

Small-scale

0.479

High

647892

MAP7
Ensconsin

1

5

Small-scale

0.479

High

647894

TNIP1
TNFAIP3-interacting protein 1

1

8

High-throughput

0.479

High

647901

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

6

Small-scale

0.479

High

647903

OCLN
Occludin

1

1

High-throughput

0.479

High

647906

DDX6L
Probable ATP-dependent RNA helicase DDX60-like

1

4

High-throughput

0.479

High

647909

SPD2A
SH3 and PX domain-containing protein 2A

1

5

High-throughput

0.479

High

647911

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

647924

CXD3
Gap junction delta-3 protein

1

5

High-throughput

0.479

High

647930

PARD3
Partitioning defective 3 homolog

1

9

High-throughput

0.479

High

647941

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.479

High

647949

FMNL2
Formin-like protein 2

1

2

High-throughput

0.479

High

647950

PANX1
Pannexin-1

1

1

High-throughput

0.479

High

647955

CAD19
Cadherin-19

1

10

High-throughput

0.479

High

647962

ECT2
Protein ECT2

1

5

High-throughput

0.479

High

647963

AGO3
Protein argonaute-3

1

11

High-throughput

0.479

High

647966

AGO4
Protein argonaute-4

1

11

High-throughput

0.479

High

647967

E41LA
Band 4.1-like protein 4A

1

4

High-throughput

0.479

High

647968

BRD7
Bromodomain-containing protein 7

1

4

High-throughput

0.479

High

647974

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

647977

AGO2
Protein argonaute-2

1

11

High-throughput

0.479

High

647978

AGO1
Protein argonaute-1

1

11

High-throughput

0.479

High

647986

MARE3
Microtubule-associated protein RP/EB family member 3

1

1

Small-scale

0.479

High

647987

HDAC5
Histone deacetylase 5

1

9

Small-scale

0.479

High

647988

LAMP3
Lysosome-associated membrane glycoprotein 3

1

5

High-throughput

0.479

High

647997

DTNA
Dystrobrevin alpha

1

10

High-throughput

0.479

High

146016

CLD4
Claudin-4

1

0

Small-scale

0.458

High

232641

TBCD4
TBC1 domain family member 4

1

0

Small-scale

0.458

High

569226

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

647899

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

647910

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

0

Small-scale

0.458

High

647938

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

0

Small-scale

0.458

High

647943

AKTS1
Proline-rich AKT1 substrate 1

1

0

Small-scale

0.458

High

647965

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.458

High

647999

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

0

Small-scale

0.458

High

483233

TPC2A
Trafficking protein particle complex subunit 2

1

4

High-throughput

0.445

High

647838

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

647925

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

647928

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

1

High-throughput

0.445

High

647969

FANCF
Fanconi anemia group F protein

1

0

High-throughput

0.438

High

49090

DHR12
Dehydrogenase/reductase SDR family member 12

1

2

High-throughput

0.437

High

132419

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

1

High-throughput

0.437

High

266316

TAD2A
Transcriptional adapter 2-alpha

1

1

High-throughput

0.437

High

305362

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.437

High

379041

MYCN
N-myc proto-oncogene protein

1

8

High-throughput

0.437

High

551999

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

647830

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

647839

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

647908

RC3H1
Roquin-1

1

3

High-throughput

0.437

High

647921

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

647937

ESR2
Estrogen receptor beta

1

4

High-throughput

0.437

High

647972

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.437

High

647875

XPC
DNA repair protein complementing XP-C cells

1

0

High-throughput

0.426

High

647960

NOL11
Nucleolar protein 11

1

1

High-throughput

0.417

High

647945

Q96KY9
CDH19 protein

1

11

High-throughput

0.407

High

393771

SCG1
Secretogranin-1

1

0

High-throughput

0.282

High

647944

SAAL1
Protein SAAL1

1

0

High-throughput

0.282

High

647976

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

1

0

High-throughput

0.279

Low

647992

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.279

Low

647897

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.249

Low

647917

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

317812

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024