Protein: DNSL1
Deoxyribonuclease-1-like 1 (EC 3.1.21.-) (DNase X) (Deoxyribonuclease I-like 1) (DNase I-like 1) (Muscle-specific DNase I-like) (XIB)

Gene: DNSL1, DNASE1L1
Organism: Homo sapiens
Interactions: 134
UniProt ID: P49184

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0004530 - deoxyribonuclease I activity
GO:0004536 - DNA nuclease activity
GO:0005576 - extracellular region
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

534780

BIP
Endoplasmic reticulum chaperone BiP

2

2

High-throughput

0.621

High

880048

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

0

High-throughput

0.602

High

660250

BDNF
Neurotrophic factor BDNF precursor form

2

0

High-throughput

0.594

High

880005

OS9
Protein OS-9

2

0

High-throughput

0.576

High

880027

CD109
CD109 antigen

2

0

High-throughput

0.576

High

880063

SIL1
Nucleotide exchange factor SIL1

2

0

High-throughput

0.576

High

880069

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

2

0

High-throughput

0.576

High

395685

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

879999

SC11A
Signal peptidase complex catalytic subunit SEC11A

2

1

High-throughput

0.549

High

880075

PLXA1
Plexin-A1

2

4

High-throughput

0.549

High

133174

QSOX1
Sulfhydryl oxidase 1

1

1

High-throughput

0.536

High

183231

LAMA5
Laminin subunit alpha-5

1

2

High-throughput

0.536

High

251144

B4GT4
Beta-1,4-galactosyltransferase 4

1

1

High-throughput

0.536

High

323974

CSTN1
Calsyntenin-1

1

1

High-throughput

0.536

High

366477

UROK
Urokinase-type plasminogen activator

1

1

High-throughput

0.536

High

409308

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

3

High-throughput

0.536

High

520783

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

3

High-throughput

0.536

High

562704

BMP1
Bone morphogenetic protein 1

1

1

High-throughput

0.536

High

648458

FGFR4
Fibroblast growth factor receptor 4

1

1

High-throughput

0.536

High

650086

FGFR3
Fibroblast growth factor receptor 3

1

1

High-throughput

0.536

High

719704

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

3

High-throughput

0.536

High

879997

LAMB2
Laminin subunit beta-2

1

1

High-throughput

0.536

High

880003

SEM3B
Semaphorin-3B

1

2

High-throughput

0.536

High

880023

CSPG4
Chondroitin sulfate proteoglycan 4

1

1

High-throughput

0.536

High

880032

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

3

High-throughput

0.536

High

880045

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

2

High-throughput

0.536

High

880046

ATS14
A disintegrin and metalloproteinase with thrombospondin motifs 14

1

2

High-throughput

0.536

High

880051

HMR1
Major histocompatibility complex class I-related protein 1

1

3

High-throughput

0.536

High

880077

ATS7
A disintegrin and metalloproteinase with thrombospondin motifs 7

1

2

High-throughput

0.536

High

160814

TOR1B
Torsin-1B

1

0

High-throughput

0.513

High

282829

CRLF1
Cytokine receptor-like factor 1

1

0

High-throughput

0.513

High

284931

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

0

High-throughput

0.513

High

350693

NOE2
Noelin-2

1

0

High-throughput

0.513

High

551843

CO6A2

1

0

High-throughput

0.513

High

566590

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.513

High

573383

ENPL
Endoplasmin

1

0

High-throughput

0.513

High

582078

PGAM2
Phosphoglycerate mutase 2

1

0

High-throughput

0.513

High

880002

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.513

High

880004

MSLN
Mesothelin

1

0

High-throughput

0.513

High

880007

MESD
LRP chaperone MESD

1

0

High-throughput

0.513

High

880008

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.513

High

880015

T132A
Transmembrane protein 132A

1

0

High-throughput

0.513

High

880018

OFUT4
GDP-fucose protein O-fucosyltransferase 4

1

0

High-throughput

0.513

High

880019

AGRF1
Adhesion G-protein coupled receptor F1

1

0

High-throughput

0.513

High

880025

GLB1L
Beta-galactosidase-1-like protein

1

0

High-throughput

0.513

High

880026

CREL2
Protein disulfide isomerase CRELD2

1

0

High-throughput

0.513

High

880036

BANP
Protein BANP

1

0

High-throughput

0.513

High

880037

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.513

High

880039

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

0

High-throughput

0.513

High

880054

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.513

High

880055

SENP5
Sentrin-specific protease 5

1

0

High-throughput

0.513

High

880056

CLP1L
Lipid scramblase CLPTM1L

1

0

High-throughput

0.513

High

880057

NAR5
Ecto-ADP-ribosyltransferase 5

1

0

High-throughput

0.513

High

880059

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.513

High

880062

CNTP3
Contactin-associated protein-like 3

1

0

High-throughput

0.513

High

880072

SE1L1
Protein sel-1 homolog 1

1

0

High-throughput

0.513

High

880061

TRI54
Tripartite motif-containing protein 54

1

1

High-throughput

0.494

High

301368

WFS1
Wolframin

1

0

High-throughput

0.493

High

555952

CADH1
Cadherin-1

1

0

High-throughput

0.493

High

697804

CALR
Calreticulin

1

0

High-throughput

0.493

High

705275

GRN
Progranulin

1

0

High-throughput

0.493

High

787934

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.493

High

788868

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.493

High

879993

SERPH
Serpin H1

1

0

High-throughput

0.493

High

880011

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

High-throughput

0.493

High

880043

NEK7
Serine/threonine-protein kinase Nek7

1

0

High-throughput

0.493

High

175333

PLXB2
Plexin-B2

1

5

High-throughput

0.489

High

251077

B4GT3
Beta-1,4-galactosyltransferase 3

1

1

High-throughput

0.489

High

296346

ATRN
Attractin

1

4

High-throughput

0.489

High

320865

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

1

High-throughput

0.489

High

380620

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

3

High-throughput

0.489

High

427830

ICAM1
Intercellular adhesion molecule 1

1

1

High-throughput

0.489

High

439680

INSR
Insulin receptor

1

3

High-throughput

0.489

High

465454

IGF1R
Insulin-like growth factor 1 receptor

1

3

High-throughput

0.489

High

603760

ITA2
Integrin alpha-2

1

1

High-throughput

0.489

High

879991

MA2A2
Alpha-mannosidase 2x

1

2

High-throughput

0.489

High

879995

PLXA3
Plexin-A3

1

5

High-throughput

0.489

High

879998

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.489

High

880000

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

2

High-throughput

0.489

High

880001

IDD
Integral membrane protein DGCR2/IDD

1

1

High-throughput

0.489

High

880006

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

1

High-throughput

0.489

High

880016

MICA
MHC class I polypeptide-related sequence A

1

4

High-throughput

0.489

High

880021

METRL
Meteorin-like protein

1

2

High-throughput

0.489

High

880028

THSD4
Thrombospondin type-1 domain-containing protein 4

1

2

High-throughput

0.489

High

880047

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

2

High-throughput

0.489

High

880060

SC11C
Signal peptidase complex catalytic subunit SEC11C

1

1

High-throughput

0.489

High

880064

CHRD
Chordin

1

2

High-throughput

0.489

High

880065

SEM6B
Semaphorin-6B

1

2

High-throughput

0.489

High

880066

SEM4G
Semaphorin-4G

1

3

High-throughput

0.489

High

880074

CEIP2
Cell surface hyaluronidase CEMIP2

1

2

High-throughput

0.489

High

880076

METRN
Meteorin

1

2

High-throughput

0.489

High

880078

ICAM5
Intercellular adhesion molecule 5

1

1

High-throughput

0.489

High

880079

MA2B2
Epididymis-specific alpha-mannosidase

1

2

High-throughput

0.489

High

880080

PLXD1
Plexin-D1

1

5

High-throughput

0.489

High

880050

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

880010

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

880031

NANGN
NANOG neighbor homeobox

1

0

High-throughput

0.458

High

880070

NTRI
Neurotrimin

1

1

High-throughput

0.445

High

880029

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

880044

LRC15
Leucine-rich repeat-containing protein 15

1

1

High-throughput

0.437

High

774748

TIMP3
Metalloproteinase inhibitor 3

1

0

High-throughput

0.426

High

880058

CGRE1
Cell growth regulator with EF hand domain protein 1

1

0

High-throughput

0.426

High

880014

MA2A1
Alpha-mannosidase 2

1

2

High-throughput

0.407

High

880009

SPCS2
Signal peptidase complex subunit 2

4

0

High-throughput

0.360

High

880082

SPCS1
Signal peptidase complex subunit 1

3

0

High-throughput

0.339

High

570377

GFAP
Glial fibrillary acidic protein

2

0

High-throughput

0.318

High

880053

TTC17
Tetratricopeptide repeat protein 17

2

0

High-throughput

0.313

High

771654

IDUA
Alpha-L-iduronidase

1

0

High-throughput

0.279

Low

879992

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.279

Low

879994

GPC3
Glypican-3

1

0

High-throughput

0.279

Low

879996

KS6A3
Ribosomal protein S6 kinase alpha-3

1

0

High-throughput

0.279

Low

880012

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

0

High-throughput

0.279

Low

880017

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

0

High-throughput

0.279

Low

880020

GP107
Protein GPR107

1

0

High-throughput

0.279

Low

880022

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

1

0

High-throughput

0.279

Low

880024

PLGT2
Protein O-glucosyltransferase 2

1

0

High-throughput

0.279

Low

880030

NDUF7
Protein arginine methyltransferase NDUFAF7, mitochondrial

1

0

High-throughput

0.279

Low

880033

ANR46
Ankyrin repeat domain-containing protein 46

1

0

High-throughput

0.279

Low

880034

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.279

Low

880035

ABD12
Lysophosphatidylserine lipase ABHD12

1

0

High-throughput

0.279

Low

880038

TTC13
Tetratricopeptide repeat protein 13

1

0

High-throughput

0.279

Low

880040

CHSTE
Carbohydrate sulfotransferase 14

1

0

High-throughput

0.279

Low

880041

NLGN2
Neuroligin-2

1

0

High-throughput

0.279

Low

880042

RS4Y2
Small ribosomal subunit protein eS4, Y isoform 2

1

0

High-throughput

0.279

Low

880049

TM131
Transmembrane protein 131

1

0

High-throughput

0.279

Low

880067

CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2

1

0

High-throughput

0.279

Low

880068

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

880071

CHPF2
Chondroitin sulfate glucuronyltransferase

1

0

High-throughput

0.279

Low

880073

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

880081

ST14
Suppressor of tumorigenicity 14 protein

1

0

High-throughput

0.279

Low

593736

PECA1
Platelet endothelial cell adhesion molecule

1

0

High-throughput

0.268

Low

217959

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

880013

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

0

High-throughput

0.232

Low

880052

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025