Protein: AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) (Apoptosis-resistant HECT-type E3 ubiquitin transferase 1)

Gene: AREL1
Organism: Homo sapiens
Interactions: 34
UniProt ID: O15033

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0006915 - apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

175466

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

20

Small-scale

0.919

High

175469

UB2L3
Ubiquitin-conjugating enzyme E2 L3

4

20

Small-scale

0.888

High

175461

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

20

Small-scale

0.845

High

175454

AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1

2

15

Small-scale

0.778

High

175467

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.647

High

175468

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

Small-scale

0.647

High

175475

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

6

High-throughput

0.628

High

175463

CRKL
Crk-like protein

2

6

High-throughput

0.594

High

175472

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

2

3

High-throughput

0.574

High

175482

PCDGG
Protocadherin gamma-B4

2

3

High-throughput

0.574

High

175486

PCDG5
Protocadherin gamma-A5

2

3

High-throughput

0.574

High

175456

SOCS1
Suppressor of cytokine signaling 1

1

7

Small-scale

0.561

High

175457

SEPT4
Septin-4

1

3

Small-scale

0.561

High

175458

HTRA2
Serine protease HTRA2, mitochondrial

1

1

Small-scale

0.561

High

175473

PIAS4
E3 SUMO-protein ligase PIAS4

1

4

Small-scale

0.561

High

175479

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

Small-scale

0.537

High

175462

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

2

High-throughput

0.489

High

175476

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

2

High-throughput

0.489

High

175484

PCDGL
Protocadherin gamma-C4

1

3

High-throughput

0.489

High

175485

PCDGE
Protocadherin gamma-B2

1

3

High-throughput

0.489

High

175459

HS90A
Heat shock protein HSP 90-alpha

1

15

High-throughput

0.479

High

175460

HS90B
Heat shock protein HSP 90-beta

1

15

High-throughput

0.479

High

175465

GSK3B
Glycogen synthase kinase-3 beta

1

4

Small-scale

0.479

High

175480

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.479

High

175478

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

175455

MOT4
Monocarboxylate transporter 4

1

4

High-throughput

0.407

High

175464

SL9A3
Sodium/hydrogen exchanger 3

1

3

High-throughput

0.407

High

175470

SL9A5
Sodium/hydrogen exchanger 5

1

3

High-throughput

0.407

High

175477

B3A4
Anion exchange protein 4

1

4

High-throughput

0.407

High

175483

S27A6
Long-chain fatty acid transport protein 6

1

1

High-throughput

0.407

High

175471

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

175474

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

175481

EVA1B
Protein eva-1 homolog B

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025