Protein: IL2RA
Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25)

Gene: IL2RA
Organism: Homo sapiens
Interactions: 63
UniProt ID: P01589

Gene Ontology (top 5):
GO:0002437 - inflammatory response to antigenic stimulus
GO:0002664 - regulation of T cell tolerance induction
GO:0004911 - interleukin-2 receptor activity
GO:0005886 - plasma membrane
GO:0005893 - interleukin-2 receptor complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

378618

IL2
Interleukin-2

10

1

Small-scale

0.970

High

378603

IL2RB
Interleukin-2 receptor subunit beta

4

2

Small-scale

0.676

High

378600

IL2RA
Interleukin-2 receptor subunit alpha

1

0

Small-scale

0.614

High

378620

TF65
Transcription factor p65

2

1

Small-scale

0.584

High

378609

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

3

High-throughput

0.536

High

378615

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

1

1

High-throughput

0.536

High

378617

AT12A
Potassium-transporting ATPase alpha chain 2

1

1

High-throughput

0.536

High

378619

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

2

High-throughput

0.536

High

378626

AT2B3
Plasma membrane calcium-transporting ATPase 3

1

2

High-throughput

0.536

High

321734

AGRL1
Adhesion G protein-coupled receptor L1

1

0

High-throughput

0.513

High

333541

NDUC2
NADH dehydrogenase [ubiquinone] 1 subunit C2

1

0

High-throughput

0.513

High

378607

SL9A1
Sodium/hydrogen exchanger 1

1

0

High-throughput

0.513

High

378608

NF1
Neurofibromin

1

0

High-throughput

0.513

High

378612

IL6RB
Interleukin-6 receptor subunit beta

1

0

High-throughput

0.513

High

378622

NTCP7
Sodium/bile acid cotransporter 7

1

0

High-throughput

0.513

High

378627

MICA
MHC class I polypeptide-related sequence A

1

0

High-throughput

0.513

High

378629

CARL1
F-actin-uncapping protein LRRC16A

1

0

High-throughput

0.513

High

378630

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

0

High-throughput

0.513

High

378631

MBOA5
Lysophospholipid acyltransferase 5

1

0

High-throughput

0.513

High

378635

NLRX1
NLR family member X1

1

0

High-throughput

0.513

High

378641

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

0

High-throughput

0.513

High

378642

SPPL3
Signal peptide peptidase-like 3

1

0

High-throughput

0.513

High

378645

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.513

High

378647

RBM14
RNA-binding protein 14

1

0

High-throughput

0.513

High

378650

ULBP3
UL16-binding protein 3

1

0

High-throughput

0.513

High

378623

SNTA1
Alpha-1-syntrophin

1

0

Small-scale

0.505

High

378640

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.489

High

378655

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.489

High

378602

IRF1
Interferon regulatory factor 1

1

1

Small-scale

0.479

High

378610

IL2RG
Cytokine receptor common subunit gamma

1

2

Small-scale

0.479

High

378614

STA5A
Signal transducer and activator of transcription 5A

1

2

Small-scale

0.479

High

378616

STA5B
Signal transducer and activator of transcription 5B

1

2

Small-scale

0.479

High

378621

REL
Proto-oncogene c-Rel

1

1

Small-scale

0.479

High

378601

ICAM1
Intercellular adhesion molecule 1

1

0

Small-scale

0.458

High

378625

STAT4
Signal transducer and activator of transcription 4

1

2

Small-scale

0.437

High

317768

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.279

Low

322688

RHBT3
Rho-related BTB domain-containing protein 3

1

0

High-throughput

0.279

Low

328344

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

0

High-throughput

0.279

Low

378624

MTX1
Metaxin-1

1

0

High-throughput

0.279

Low

378628

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

0

High-throughput

0.279

Low

378632

TMT1B
Thiol S-methyltransferase TMT1B

1

0

High-throughput

0.279

Low

378633

INT8
Integrator complex subunit 8

1

0

High-throughput

0.279

Low

378634

DYM
Dymeclin

1

0

High-throughput

0.279

Low

378636

TM192
Transmembrane protein 192

1

0

High-throughput

0.279

Low

378637

PGAM4
Probable phosphoglycerate mutase 4

1

0

High-throughput

0.279

Low

378638

INT1
Integrator complex subunit 1

1

0

High-throughput

0.279

Low

378639

ARL10
ADP-ribosylation factor-like protein 10

1

0

High-throughput

0.279

Low

378643

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.279

Low

378644

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

378646

INT4
Integrator complex subunit 4

1

0

High-throughput

0.279

Low

378649

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

High-throughput

0.279

Low

378651

EMRE
Essential MCU regulator, mitochondrial

1

0

High-throughput

0.279

Low

378652

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.279

Low

378653

TM9S3
Transmembrane 9 superfamily member 3

1

0

High-throughput

0.279

Low

378654

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.279

Low

169379

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

Small-scale

0.249

Low

378604

ITF2
Transcription factor 4

1

0

Small-scale

0.249

Low

378605

GATA1
Erythroid transcription factor

1

0

Small-scale

0.249

Low

378606

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.249

Low

378611

ELF1
ETS-related transcription factor Elf-1

1

0

Small-scale

0.249

Low

378613

EIF1
Eukaryotic translation initiation factor 1

1

0

Small-scale

0.249

Low

378648

PASK
PAS domain-containing serine/threonine-protein kinase

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025