Protein: PYRC
Dihydroorotase (DHOase) (EC 3.5.2.3)

Gene: PYRC, URA4
Organism: Saccharomyces cerevisiae S288C
Interactions: 41
UniProt ID: P20051

Gene Ontology (top 5):
GO:0004151 - dihydroorotase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 - pyrimidine nucleotide biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

627803

JSN1
Protein JSN1

2

0

High-throughput

0.588

High

626557

PNPP
4-nitrophenylphosphatase

2

0

High-throughput

0.587

High

448921

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.518

High

439557

LEU1
2-isopropylmalate synthase

1

2

High-throughput

0.479

High

460309

SYV
Valine--tRNA ligase, mitochondrial

1

3

High-throughput

0.479

High

585468

KCY
Uridylate kinase

1

1

High-throughput

0.479

High

627782

CYPD
Peptidyl-prolyl cis-trans isomerase D

1

1

High-throughput

0.479

High

627790

RT107
Regulator of Ty1 transposition protein 107

1

1

High-throughput

0.479

High

627791

PIK1
Phosphatidylinositol 4-kinase PIK1

1

1

High-throughput

0.479

High

627798

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

High-throughput

0.479

High

627805

MMS2
Ubiquitin-conjugating enzyme variant MMS2

1

3

High-throughput

0.479

High

627809

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

1

High-throughput

0.479

High

627779

SAN1
Protein SAN1

1

0

Small-scale

0.460

High

360946

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

High-throughput

0.458

High

510954

IPB2
Protease B inhibitor 2

1

0

High-throughput

0.458

High

627780

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

627781

MLS1
Malate synthase 1

1

0

High-throughput

0.458

High

627785

FAT2
Oxalate--CoA ligase

1

0

High-throughput

0.458

High

627786

ECM21
Protein ECM21

1

0

High-throughput

0.458

High

627788

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.458

High

627789

SDO1L
Restriction of telomere capping protein 3

1

0

High-throughput

0.458

High

627792

IFH1
Protein IFH1

1

0

High-throughput

0.458

High

627794

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

0

High-throughput

0.458

High

627795

IMB4
Importin subunit beta-4

1

0

High-throughput

0.458

High

627799

SA185
SIT4-associating protein SAP185

1

0

High-throughput

0.458

High

627800

SUM1
Suppressor of mar1-1 protein

1

0

High-throughput

0.458

High

627801

TIM54
Mitochondrial import inner membrane translocase subunit TIM54

1

0

High-throughput

0.458

High

627802

MTR4
ATP-dependent RNA helicase DOB1

1

0

High-throughput

0.458

High

627804

BCA2
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.458

High

627807

YM54
Uncharacterized protein YMR196W

1

0

High-throughput

0.458

High

627808

RGC1
Regulator of the glycerol channel 1

1

0

High-throughput

0.458

High

627796

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

481853

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.437

High

627810

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

627783

PDX3
Pyridoxamine 5'-phosphate oxidase

1

0

High-throughput

0.249

Low

627784

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

0

High-throughput

0.249

Low

627787

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

627793

GDI1
Rab GDP-dissociation inhibitor

1

0

High-throughput

0.249

Low

627797

RIC1
Guanine nucleotide exchange factor subunit RIC1

1

0

High-throughput

0.249

Low

627806

ENG1
Glucan endo-1,3-beta-D-glucosidase 1

1

0

High-throughput

0.249

Low

627811

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025