Protein: LEU1
2-isopropylmalate synthase (EC 2.3.3.13) (Alpha-IPM synthase) (Alpha-isopropylmalate synthase)

Gene: LEU1, LEU4
Organism: Saccharomyces cerevisiae S288C
Interactions: 57
UniProt ID: P06208

Gene Ontology (top 5):
GO:0003852 - 2-isopropylmalate synthase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0009098 - L-leucine biosynthetic process
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

439600

LEU9
2-isopropylmalate synthase 2, mitochondrial

8

14

Small-scale

0.964

High

439548

LEU1
2-isopropylmalate synthase

2

14

High-throughput

0.762

High

391989

HSP82
ATP-dependent molecular chaperone HSP82

3

8

High-throughput

0.640

High

439549

HSP77
Import motor subunit, mitochondrial

2

5

High-throughput

0.584

High

439564

HS104
Heat shock protein 104

2

6

High-throughput

0.584

High

439585

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

5

High-throughput

0.584

High

439555

PHO85
Cyclin-dependent protein kinase PHO85

1

4

High-throughput

0.501

High

439592

RSA3
Ribosome assembly protein 3

1

1

High-throughput

0.489

High

439571

LOT5
Protein LOT5

1

0

High-throughput

0.486

High

439558

MCK1
Protein kinase MCK1

1

0

High-throughput

0.480

High

439559

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

0

High-throughput

0.480

High

439576

AKL1
Serine/threonine-protein kinase AKL1

1

0

High-throughput

0.480

High

439552

HSC82
ATP-dependent molecular chaperone HSC82

1

8

High-throughput

0.479

High

439553

KCY
Uridylate kinase

1

1

High-throughput

0.479

High

439556

MDHM
Malate dehydrogenase, mitochondrial

1

2

Small-scale

0.479

High

439557

PYRC
Dihydroorotase

1

2

High-throughput

0.479

High

439562

KIP1
Kinesin-like protein KIP1

1

1

High-throughput

0.479

High

439565

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

439566

HOG1
Mitogen-activated protein kinase HOG1

1

2

High-throughput

0.479

High

439570

HSP78
Heat shock protein 78, mitochondrial

1

6

High-throughput

0.479

High

439575

LONM
Lon protease homolog, mitochondrial

1

3

High-throughput

0.479

High

439581

IMB4
Importin subunit beta-4

1

1

High-throughput

0.479

High

439588

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

439591

ESP1
Separin

1

1

High-throughput

0.479

High

439561

IMG2
Large ribosomal subunit protein mL49

1

0

High-throughput

0.458

High

439568

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

439572

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

439573

RM10
Large ribosomal subunit protein uL15m

1

0

High-throughput

0.458

High

439574

RM17
Large ribosomal subunit protein mL46

1

0

High-throughput

0.458

High

439577

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

439578

SDO1L
Restriction of telomere capping protein 3

1

0

High-throughput

0.458

High

439579

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

Small-scale

0.458

High

439582

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

439586

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

439587

TIM54
Mitochondrial import inner membrane translocase subunit TIM54

1

0

High-throughput

0.458

High

439589

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

439590

ATP19
ATP synthase subunit K, mitochondrial

1

0

High-throughput

0.458

High

439595

MHR1
Large ribosomal subunit protein mL67

1

0

High-throughput

0.458

High

439598

YP022
Zinc finger protein YPR022C

1

0

High-throughput

0.458

High

439550

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.445

High

439551

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.445

High

439583

SSB2
Ribosome-associated molecular chaperone SSB2

1

10

High-throughput

0.445

High

439596

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.445

High

439560

SIS1
Protein SIS1

1

6

High-throughput

0.437

High

439563

TF2B
Transcription initiation factor IIB

1

6

High-throughput

0.437

High

439569

SC61A
Protein transport protein SEC61

1

2

High-throughput

0.437

High

439594

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

439599

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.437

High

439601

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.437

High

439584

PXA1
Peroxisomal long-chain fatty acid import protein 2

1

0

High-throughput

0.282

High

439593

ISR1
Serine/threonine-protein kinase ISR1

1

0

High-throughput

0.261

Low

439554

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

0

High-throughput

0.249

Low

439567

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

439580

GDI1
Rab GDP-dissociation inhibitor

1

0

High-throughput

0.249

Low

439597

YL053
Putative uncharacterized protein YLR053C

1

0

Small-scale

0.249

Low

439602

TFB5
General transcription and DNA repair factor IIH subunit TFB5

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025