Protein: DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3 (D-2HG--pyruvate transhydrogenase DLD3) (EC 1.1.99.40) ((R)-2-hydroxyglutarate--pyruvate transhydrogenase) (D-lactate dehydrogenase [cytochrome] 3) (EC 1.1.2.4) (D-lactate ferricytochrome C oxidoreductase) (D-LCR)

Gene: DLD3
Organism: Saccharomyces cerevisiae S288C
Interactions: 69
UniProt ID: P39976

Gene Ontology (top 5):
GO:0004458 - D-lactate dehydrogenase (cytochrome) activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0019249 - lactate biosynthetic process
GO:0030447 - filamentous growth

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

727051

HS104
Heat shock protein 104

3

3

Small-scale

0.633

High

816082

DLD2
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2

1

6

High-throughput

0.618

High

816081

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.584

High

816104

HRT3
F-box protein HRT3

1

0

Small-scale

0.549

High

816102

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

1

High-throughput

0.541

High

524043

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.536

High

544979

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.536

High

816090

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

576971

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.513

High

816106

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.479

High

448540

RHO1
GTP-binding protein RHO1

1

1

High-throughput

0.479

High

579447

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.479

High

739377

ZUO1
Zuotin

1

1

Small-scale

0.479

High

747874

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

750949

PRS7
26S proteasome regulatory subunit 7 homolog

1

4

High-throughput

0.479

High

803552

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

815124

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

816088

HST2
NAD-dependent protein deacetylase HST2

1

3

High-throughput

0.479

High

816097

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

1

Small-scale

0.479

High

816100

ATG9
Autophagy-related protein 9

1

2

High-throughput

0.479

High

149783

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

435117

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

464598

PBS2
MAP kinase kinase PBS2

1

0

High-throughput

0.458

High

627794

PYRC
Dihydroorotase

1

0

High-throughput

0.458

High

672889

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

674645

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

736788

AROG
Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited

1

0

High-throughput

0.458

High

737867

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.458

High

750671

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

778347

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

802194

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

816080

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

816083

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

816085

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

816087

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

0

Small-scale

0.458

High

816089

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

0

High-throughput

0.458

High

816091

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

816093

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

Small-scale

0.458

High

816094

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

526772

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

652881

TRX2
Thioredoxin-2

1

1

Small-scale

0.445

High

741637

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

742857

HSP79
Heat shock protein homolog SSE2

1

6

High-throughput

0.445

High

804186

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.445

High

816079

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

816103

HSP42
Heat shock protein 42

1

1

High-throughput

0.445

High

670746

SIS1
Protein SIS1

1

2

High-throughput

0.437

High

707180

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

795000

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

816086

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

816092

PRS8
26S proteasome regulatory subunit 8 homolog

1

1

High-throughput

0.437

High

816095

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.437

High

816099

AP3D
AP-3 complex subunit delta

1

3

High-throughput

0.437

High

597735

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

816084

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.426

High

383718

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

410153

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433660

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

441926

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

455081

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

503062

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504230

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

689477

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

747384

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

807808

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

816096

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

816098

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

816101

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

816105

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025