Protein: MLS1
Malate synthase 1 (EC 2.3.3.9)

Gene: MLS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 72
UniProt ID: P30952

Gene Ontology (top 5):
GO:0004474 - malate synthase activity
GO:0005737 - cytoplasm
GO:0005777 - peroxisome
GO:0005782 - peroxisomal matrix
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

723593

MLS1
Malate synthase 1

1

1

Small-scale

0.621

High

723631

PEX9
Peroxisomal targeting signal receptor 9

2

1

Small-scale

0.584

High

704573

SBA1
Co-chaperone protein SBA1

1

0

Small-scale

0.504

High

437891

KAPC
cAMP-dependent protein kinase type 3

1

0

High-throughput

0.480

High

574652

KSS1
Mitogen-activated protein kinase KSS1

1

0

High-throughput

0.480

High

651907

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

0

High-throughput

0.480

High

666154

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

0

High-throughput

0.480

High

723610

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.480

High

723616

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.480

High

723617

IKS1
Probable serine/threonine-protein kinase IKS1

1

0

High-throughput

0.480

High

723620

ENT3
Epsin-3

1

0

Small-scale

0.480

High

723622

VID30
GID complex subunit 1

1

0

High-throughput

0.480

High

723635

PSK2
Serine/threonine-protein kinase PSK2

1

0

High-throughput

0.480

High

392374

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

460316

SYV
Valine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

481863

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

578998

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

723603

TPS3
Trehalose synthase complex regulatory subunit TPS3

1

1

High-throughput

0.479

High

723604

TSL1
Trehalose synthase complex regulatory subunit TSL1

1

1

High-throughput

0.479

High

723630

PROA
Gamma-glutamyl phosphate reductase

1

2

High-throughput

0.479

High

366645

ARGI
Arginase

1

0

High-throughput

0.458

High

510956

IPB2
Protease B inhibitor 2

1

0

High-throughput

0.458

High

523295

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.458

High

576048

AROF
Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited

1

0

High-throughput

0.458

High

585475

KCY
Uridylate kinase

1

0

High-throughput

0.458

High

627781

PYRC
Dihydroorotase

1

0

High-throughput

0.458

High

645322

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

663770

PEX1
Peroxisomal ATPase PEX1

1

0

High-throughput

0.458

High

672002

MSH3
DNA mismatch repair protein MSH3

1

0

High-throughput

0.458

High

704858

KIP1
Kinesin-like protein KIP1

1

0

High-throughput

0.458

High

721758

XPO1
Exportin-1

1

0

High-throughput

0.458

High

723594

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

723596

CYPD
Peptidyl-prolyl cis-trans isomerase D

1

0

High-throughput

0.458

High

723599

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

0

High-throughput

0.458

High

723600

FAT2
Oxalate--CoA ligase

1

0

High-throughput

0.458

High

723601

ECM21
Protein ECM21

1

0

High-throughput

0.458

High

723602

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.458

High

723606

SDO1L
Restriction of telomere capping protein 3

1

0

High-throughput

0.458

High

723607

MPT5
Suppressor protein MPT5

1

0

High-throughput

0.458

High

723608

PIK1
Phosphatidylinositol 4-kinase PIK1

1

0

High-throughput

0.458

High

723611

IMB4
Importin subunit beta-4

1

0

High-throughput

0.458

High

723613

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

High-throughput

0.458

High

723618

TIM54
Mitochondrial import inner membrane translocase subunit TIM54

1

0

High-throughput

0.458

High

723621

BCA2
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.458

High

723625

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

723627

CA120
CCR4-NOT transcriptional complex subunit CAF120

1

0

High-throughput

0.458

High

723628

RIA1
Ribosome assembly protein 1

1

0

High-throughput

0.458

High

723632

RGC1
Regulator of the glycerol channel 1

1

0

High-throughput

0.458

High

723634

CND3
Condensin complex subunit 3

1

0

High-throughput

0.458

High

723637

AB140
tRNA(Thr)

1

0

High-throughput

0.458

High

723641

PEX11
Peroxisomal membrane protein PMP27

1

0

Small-scale

0.458

High

723624

FMP48
Probable serine/threonine-protein kinase FMP48

1

1

High-throughput

0.457

High

723638

SOG2
Leucine-rich repeat-containing protein SOG2

1

0

High-throughput

0.438

High

723595

PRP40
Pre-mRNA-processing protein PRP40

1

0

High-throughput

0.261

Low

723605

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.261

Low

723612

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

High-throughput

0.261

Low

723623

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.261

Low

723633

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.261

Low

723636

AUS1
ATP-dependent permease AUS1

1

0

High-throughput

0.261

Low

360955

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

High-throughput

0.249

Low

590182

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

0

High-throughput

0.249

Low

723597

APE3
Aminopeptidase Y

1

0

High-throughput

0.249

Low

723598

PDX3
Pyridoxamine 5'-phosphate oxidase

1

0

High-throughput

0.249

Low

723609

IFH1
Protein IFH1

1

0

High-throughput

0.249

Low

723614

HOS4
Protein HOS4

1

0

High-throughput

0.249

Low

723615

EGT2
Protein EGT2

1

0

High-throughput

0.249

Low

723619

MTR4
ATP-dependent RNA helicase DOB1

1

0

High-throughput

0.249

Low

723626

ENG1
Glucan endo-1,3-beta-D-glucosidase 1

1

0

High-throughput

0.249

Low

723629

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

723639

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

723640

RDL1
Thiosulfate:glutathione sulfurtransferase

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025