Protein: TEM1
Protein TEM1

Gene: TEM1
Organism: Saccharomyces cerevisiae S288C
Interactions: 190
UniProt ID: P38987

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005816 - spindle pole body
GO:0023056 - positive regulation of signaling
GO:0031536 - positive regulation of exit from mitosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

686890

BUB2
Mitotic check point protein BUB2

9

20

Small-scale

0.974

High

694135

CDC15
Cell division control protein 15

8

13

Small-scale

0.971

High

734602

NUD1
Protein NUD1

2

11

Small-scale

0.757

High

808522

BFA1
Mitotic check point protein BFA1

17

0

Small-scale

0.732

High

808569

IQG1
Ras GTPase-activating-like protein IQG1

2

20

Small-scale

0.700

High

797366

AMN1
Antagonist of mitotic exit network protein 1

4

1

Small-scale

0.697

High

808502

TEM1
Protein TEM1

1

18

Small-scale

0.692

High

721935

XPO1
Exportin-1

1

2

High-throughput

0.691

High

575946

CYPH
Peptidyl-prolyl cis-trans isomerase

1

3

High-throughput

0.618

High

680582

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

1

3

High-throughput

0.618

High

364530

CDK1
Cyclin-dependent kinase 1

1

4

High-throughput

0.618

High

645924

DBF2
Cell cycle protein kinase DBF2

1

11

High-throughput

0.618

High

739963

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

9

Small-scale

0.618

High

808532

RHO5
GTP-binding protein RHO5

1

20

High-throughput

0.618

High

460970

LTE1
Guanine nucleotide exchange factor LTE1

1

0

Small-scale

0.586

High

666184

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

3

High-throughput

0.579

High

671635

SCJ1
DnaJ-related protein SCJ1

1

3

High-throughput

0.578

High

675998

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.578

High

779182

NDK
Nucleoside diphosphate kinase

2

1

High-throughput

0.578

High

808535

CDC14
Tyrosine-protein phosphatase CDC14

1

9

Small-scale

0.573

High

807046

CH10
10 kDa heat shock protein, mitochondrial

2

1

High-throughput

0.566

High

808555

NMA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

2

1

High-throughput

0.566

High

808556

ATG17
Autophagy-related protein 17

2

1

High-throughput

0.566

High

590623

HSP26
Heat shock protein 26

2

1

High-throughput

0.565

High

679676

CDC48
Cell division control protein 48

2

9

High-throughput

0.558

High

745273

ELM1
Serine/threonine-protein kinase ELM1

1

9

High-throughput

0.555

High

656462

KC11
Casein kinase I homolog 1

1

10

High-throughput

0.553

High

737859

HOG1
Mitogen-activated protein kinase HOG1

1

3

High-throughput

0.553

High

751665

SEC3
Exocyst complex component SEC3

1

14

High-throughput

0.553

High

808537

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

3

High-throughput

0.553

High

808568

GIN4
Serine/threonine-protein kinase GIN4

1

19

High-throughput

0.553

High

808517

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

2

3

High-throughput

0.543

High

675289

DMC1
Meiotic recombination protein DMC1

2

2

High-throughput

0.539

High

771739

DHSO1
Sorbitol dehydrogenase 1

2

2

High-throughput

0.539

High

633548

SAR1
Small COPII coat GTPase SAR1

1

20

High-throughput

0.536

High

737723

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

3

High-throughput

0.536

High

646038

KIN3
Serine/threonine-protein kinase KIN3

1

16

High-throughput

0.528

High

609057

SKI3
Superkiller protein 3

1

0

High-throughput

0.517

High

664288

SSD1
Protein SSD1

1

0

High-throughput

0.513

High

808547

NUP53
Nucleoporin NUP53

1

0

High-throughput

0.513

High

386706

TBB
Tubulin beta chain

1

6

High-throughput

0.500

High

394557

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.500

High

486173

TBA1
Tubulin alpha-1 chain

1

6

High-throughput

0.500

High

486459

TBA3
Tubulin alpha-3 chain

1

6

High-throughput

0.500

High

709751

BMH1
Protein BMH1

1

2

High-throughput

0.500

High

734097

EF2
Elongation factor 2

1

2

High-throughput

0.500

High

808548

ATG16
Autophagy protein 16

1

0

High-throughput

0.494

High

366656

ARGI
Arginase

1

1

High-throughput

0.494

High

576966

AMPL
Vacuolar aminopeptidase 1

1

3

High-throughput

0.494

High

805373

DNPEP
Aspartyl aminopeptidase 4

1

3

High-throughput

0.494

High

808529

PRA1
Prenylated Rab acceptor 1

1

16

High-throughput

0.494

High

453150

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

4

High-throughput

0.489

High

518292

IF4A
ATP-dependent RNA helicase eIF4A

1

1

High-throughput

0.489

High

598863

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

1

High-throughput

0.489

High

635960

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

6

High-throughput

0.489

High

737371

EF1B
Elongation factor 1-beta

1

1

High-throughput

0.489

High

750188

UFD4
Ubiquitin fusion degradation protein 4

1

7

High-throughput

0.489

High

779055

EF1G2
Elongation factor 1-gamma 2

1

1

High-throughput

0.489

High

794304

DUG2
Probable di- and tripeptidase DUG2

1

2

High-throughput

0.489

High

798051

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

5

High-throughput

0.489

High

801805

YHJ3
Uncharacterized protein YHR033W

1

2

High-throughput

0.489

High

808505

FHP
Flavohemoprotein

1

1

High-throughput

0.489

High

808524

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

5

High-throughput

0.489

High

808543

COFI
Cofilin

1

2

High-throughput

0.489

High

808545

HAS1
ATP-dependent RNA helicase HAS1

1

3

High-throughput

0.489

High

808546

CLU
Clustered mitochondria protein 1

1

1

High-throughput

0.489

High

808549

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.489

High

808553

YM71
NADP-dependent 3-hydroxy acid dehydrogenase

1

7

High-throughput

0.489

High

808565

YTM1
Ribosome biogenesis protein YTM1

1

6

High-throughput

0.489

High

808562

PRM3
Pheromone-regulated membrane protein 3

1

0

High-throughput

0.486

High

808564

CDC53
Cell division control protein 53

1

6

Small-scale

0.479

High

757873

UBX1
UBX domain-containing protein 1

1

1

High-throughput

0.470

High

703816

LAC1
Ceramide synthase LAC1

1

1

High-throughput

0.464

High

747678

MNS1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

1

High-throughput

0.464

High

808510

WRIP1
DNA-dependent ATPase MGS1

1

6

High-throughput

0.464

High

808550

HMO1
High mobility group protein 1

1

6

High-throughput

0.464

High

808554

ECI1
3,2-trans-enoyl-CoA isomerase

1

2

High-throughput

0.464

High

808558

DHSO2
Sorbitol dehydrogenase 2

1

2

High-throughput

0.464

High

808513

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

367382

CISY1
Citrate synthase, mitochondrial

1

1

High-throughput

0.457

High

368666

PMG1
Phosphoglycerate mutase 1

1

2

High-throughput

0.457

High

405089

LEU3
3-isopropylmalate dehydrogenase

1

3

High-throughput

0.457

High

408323

GAL1
Galactokinase

1

1

High-throughput

0.457

High

408575

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

4

High-throughput

0.457

High

416431

HXKA
Hexokinase-1

1

4

High-throughput

0.457

High

439335

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.457

High

452904

ATPA
ATP synthase subunit alpha, mitochondrial

1

9

High-throughput

0.457

High

484760

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

3

High-throughput

0.457

High

531327

METK1
S-adenosylmethionine synthase 1

1

2

High-throughput

0.457

High

554924

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

8

High-throughput

0.457

High

579387

HSC82
ATP-dependent molecular chaperone HSC82

1

9

High-throughput

0.457

High

592248

VATB
V-type proton ATPase subunit B

1

9

High-throughput

0.457

High

594945

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

5

High-throughput

0.457

High

597137

BIP
Endoplasmic reticulum chaperone BiP

1

10

High-throughput

0.457

High

599020

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

1

High-throughput

0.457

High

607759

HXKG
Glucokinase-1

1

4

High-throughput

0.457

High

621368

METK2
S-adenosylmethionine synthase 2

1

2

High-throughput

0.457

High

644777

CLH
Clathrin heavy chain

1

4

High-throughput

0.457

High

661626

MPCP
Mitochondrial phosphate carrier protein

1

2

High-throughput

0.457

High

760255

BMH2
Protein BMH2

1

2

High-throughput

0.457

High

808503

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.457

High

808521

TCPQ
T-complex protein 1 subunit theta

1

4

High-throughput

0.457

High

808541

PRS8
26S proteasome regulatory subunit 8 homolog

1

1

High-throughput

0.457

High

808561

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

2

High-throughput

0.457

High

808563

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

2

High-throughput

0.457

High

808572

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.457

High

367023

ATPB
ATP synthase subunit beta, mitochondrial

1

9

High-throughput

0.437

High

438691

SC160
Protein SCP160

1

4

High-throughput

0.437

High

636577

PSA7
Probable proteasome subunit alpha type-7

1

2

High-throughput

0.437

High

734424

BTAF1
TATA-binding protein-associated factor MOT1

1

5

High-throughput

0.437

High

734772

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

4

High-throughput

0.437

High

735718

VA0D
V-type proton ATPase subunit d

1

2

High-throughput

0.437

High

745158

CACP
Carnitine O-acetyltransferase, mitochondrial

1

1

High-throughput

0.437

High

763828

SKI2
Antiviral helicase SKI2

1

1

High-throughput

0.437

High

782520

NU133
Nucleoporin NUP133

1

1

High-throughput

0.437

High

801996

MSC7
Putative aldehyde dehydrogenase-like protein YHR039C

1

4

High-throughput

0.437

High

806022

KEL1
Kelch repeat-containing protein 1

1

1

Small-scale

0.437

High

808504

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.437

High

808506

BDH1
(R,R)-butanediol dehydrogenase

1

2

High-throughput

0.437

High

808511

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

2

High-throughput

0.437

High

808512

TM108
Protein TMA108

1

6

High-throughput

0.437

High

808516

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

7

High-throughput

0.437

High

808520

MTR4
ATP-dependent RNA helicase DOB1

1

1

High-throughput

0.437

High

808525

KEL2
Kelch repeat-containing protein 2

1

1

Small-scale

0.437

High

808531

IPI3
Pre-rRNA-processing protein IPI3

1

4

High-throughput

0.437

High

808533

NOP13
Nucleolar protein 13

1

5

High-throughput

0.437

High

808540

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

1

High-throughput

0.437

High

510487

HSP77
Import motor subunit, mitochondrial

1

11

High-throughput

0.407

High

544869

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.407

High

741579

HSP7F
Heat shock protein homolog SSE1

1

9

High-throughput

0.407

High

808509

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.407

High

808566

HUA2
Protein HUA2

2

0

High-throughput

0.323

High

808526

NIF3
NGG1-interacting factor 3

2

0

High-throughput

0.317

High

808544

DIG1
Down-regulator of invasive growth 1

2

0

High-throughput

0.314

High

808508

EDC3
Enhancer of mRNA-decapping protein 3

2

0

High-throughput

0.307

High

808523

YJ26
Uncharacterized protein YJR056C

2

0

High-throughput

0.307

High

427985

HEM2
Delta-aminolevulinic acid dehydratase

1

0

High-throughput

0.282

High

479683

F16P
Fructose-1,6-bisphosphatase

1

0

High-throughput

0.282

High

604431

KHSE
Homoserine kinase

1

0

High-throughput

0.282

High

746273

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.282

High

793841

PANB
3-methyl-2-oxobutanoate hydroxymethyltransferase

1

0

High-throughput

0.282

High

797261

YBY7
UPF0303 protein YBR137W

1

0

High-throughput

0.282

High

808507

HPA3
D-amino-acid N-acetyltransferase HPA3

1

0

High-throughput

0.282

High

808514

YJV8
Putative acetyltransferase YJL218W

1

0

High-throughput

0.282

High

450721

KAD2
Adenylate kinase

1

0

High-throughput

0.279

Low

453947

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.279

Low

455499

PMM
Phosphomannomutase

1

0

High-throughput

0.279

Low

488609

RIR2
Ribonucleoside-diphosphate reductase small chain 1

1

0

High-throughput

0.279

Low

638719

RIR1
Ribonucleoside-diphosphate reductase large chain 1

1

0

High-throughput

0.279

Low

726566

VATC
V-type proton ATPase subunit C

1

0

High-throughput

0.279

Low

740659

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.279

Low

751356

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.279

Low

806125

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.279

Low

808518

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.279

Low

808527

GID10
GID complex substrate-recognition subunit 10

1

0

High-throughput

0.279

Low

808552

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.279

Low

808570

PST2
Protoplast secreted protein 2

1

0

High-throughput

0.279

Low

149210

FOB1
DNA replication fork-blocking protein FOB1

1

0

High-throughput

0.265

Low

754395

SEC66
Translocation protein SEC66

1

0

High-throughput

0.265

Low

806684

AIM18
Altered inheritance of mitochondria protein 18, mitochondrial

1

0

High-throughput

0.265

Low

808519

BIT61
Target of rapamycin complex 2 subunit BIT61

1

0

High-throughput

0.265

Low

808530

SNZ2
Probable pyridoxal 5'-phosphate synthase subunit SNZ2

1

0

High-throughput

0.265

Low

808534

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.265

Low

808567

WTM2
Transcriptional modulator WTM2

1

0

High-throughput

0.265

Low

804079

GIC1
GTPase-interacting component 1

1

0

Small-scale

0.261

Low

432324

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.261

Low

453601

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.261

Low

572580

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.261

Low

585554

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.261

Low

622360

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.261

Low

626734

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.261

Low

645411

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.261

Low

808515

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.261

Low

627759

TYR1
Prephenate dehydrogenase [NADP(+)]

1

0

High-throughput

0.249

Low

746731

KPR1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.249

Low

805587

LSM12
Protein LSM12

1

0

High-throughput

0.249

Low

806522

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.249

Low

808528

YG5X
Putative methyltransferase YGR283C

1

0

High-throughput

0.249

Low

808536

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.249

Low

808539

MAP1
Methionine aminopeptidase 1

1

0

High-throughput

0.249

Low

808542

UTP6
U3 small nucleolar RNA-associated protein 6

1

0

High-throughput

0.249

Low

808551

ARMT1
Damage-control phosphatase YMR027W

1

0

High-throughput

0.249

Low

808557

TRM3
tRNA

1

0

High-throughput

0.249

Low

808559

CMS1
Protein CMS1

1

0

High-throughput

0.249

Low

808560

GSHB
Glutathione synthetase GSH2

1

0

High-throughput

0.249

Low

808571

PAA1
Polyamine N-acetyltransferase 1

1

0

High-throughput

0.249

Low

678916

YCX7
Putative uncharacterized protein YCR087W

1

0

High-throughput

0.238

Low

803820

RRF1
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.238

Low

808538

BLH1
Cysteine proteinase 1, mitochondrial

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025