Protein: SPT21
Protein SPT21

Gene: SPT21
Organism: Saccharomyces cerevisiae S288C
Interactions: 233
UniProt ID: P35209

Gene Ontology (top 5):
GO:0000183 - rDNA heterochromatin formation
GO:0000781 - chromosome, telomeric region
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0030466 - silent mating-type cassette heterochromatin formation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

684615

CDC20
APC/C activator protein CDC20

2

1

High-throughput

0.586

High

763870

SPT10
Protein SPT10

2

0

Small-scale

0.569

High

544404

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.536

High

381061

H2B1
Histone H2B.1

1

1

High-throughput

0.479

High

381482

H2B2
Histone H2B.2

1

1

High-throughput

0.479

High

614818

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

1

High-throughput

0.479

High

643627

SNF2
Transcription regulatory protein SNF2

1

3

High-throughput

0.479

High

678648

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

1

High-throughput

0.479

High

709681

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

742818

HSP79
Heat shock protein homolog SSE2

1

3

High-throughput

0.479

High

743013

SWI3
SWI/SNF complex subunit SWI3

1

1

High-throughput

0.479

High

743077

STH1
Nuclear protein STH1/NPS1

1

3

High-throughput

0.479

High

744821

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

1

High-throughput

0.479

High

750183

UFD4
Ubiquitin fusion degradation protein 4

1

1

High-throughput

0.479

High

750820

PRS6B
26S proteasome regulatory subunit 6B homolog

1

1

High-throughput

0.479

High

760230

BMH2
Protein BMH2

1

1

High-throughput

0.479

High

762940

SPT7
SAGA complex subunit SPT7

1

1

High-throughput

0.479

High

763308

TAF14
Transcription initiation factor TFIID subunit 14

1

1

High-throughput

0.479

High

764059

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

2

High-throughput

0.479

High

764087

PRS4
26S proteasome regulatory subunit 4 homolog

1

1

High-throughput

0.479

High

764102

RSC8
Chromatin structure-remodeling complex protein RSC8

1

1

High-throughput

0.479

High

764116

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

High-throughput

0.479

High

764124

CDH1
APC/C activator protein CDH1

1

1

High-throughput

0.479

High

764136

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

764147

SKY1
Serine/threonine-protein kinase SKY1

1

1

High-throughput

0.479

High

764171

NEW1
[NU+] prion formation protein 1

1

1

High-throughput

0.479

High

764182

H2AZ
Histone H2A.Z

1

1

High-throughput

0.479

High

382020

H4
Histone H4

1

0

High-throughput

0.458

High

408312

GAL1
Galactokinase

1

0

High-throughput

0.458

High

416810

DNLI1
DNA ligase 1

1

0

High-throughput

0.458

High

419691

H2A2
Histone H2A.2

1

0

High-throughput

0.458

High

452729

ADR1
Regulatory protein ADR1

1

0

High-throughput

0.458

High

453930

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.458

High

483773

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

High-throughput

0.458

High

486770

CDC16
Anaphase-promoting complex subunit CDC16

1

0

High-throughput

0.458

High

506240

HAP1
Heme-responsive zinc finger transcription factor HAP1

1

0

High-throughput

0.458

High

553528

PDR1
Transcription factor PDR1

1

0

High-throughput

0.458

High

561085

PCY1
Choline-phosphate cytidylyltransferase

1

0

High-throughput

0.458

High

564652

STE12
Protein STE12

1

0

High-throughput

0.458

High

574790

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

0

High-throughput

0.458

High

597726

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.458

High

619417

MED14
Mediator of RNA polymerase II transcription subunit 14

1

0

High-throughput

0.458

High

624894

MED15
Mediator of RNA polymerase II transcription subunit 15

1

0

High-throughput

0.458

High

636924

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.458

High

640551

UBC1
Ubiquitin-conjugating enzyme E2 1

1

0

High-throughput

0.458

High

645045

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

649950

SIN3
Transcriptional regulatory protein SIN3

1

0

High-throughput

0.458

High

652867

TRX2
Thioredoxin-2

1

0

High-throughput

0.458

High

664273

SSD1
Protein SSD1

1

0

High-throughput

0.458

High

676715

GBP2
Serine/arginine

1

0

High-throughput

0.458

High

676907

SRO9
RNA-binding protein SRO9

1

0

High-throughput

0.458

High

677674

MRC1
Mediator of replication checkpoint protein 1

1

0

High-throughput

0.458

High

678947

NOT1
General negative regulator of transcription subunit 1

1

0

High-throughput

0.458

High

709351

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.458

High

721833

XPO1
Exportin-1

1

0

High-throughput

0.458

High

737824

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.458

High

738147

NGG1
SAGA complex subunit NGG1

1

0

High-throughput

0.458

High

743177

PP12
Serine/threonine-protein phosphatase PP1-2

1

0

High-throughput

0.458

High

743602

RTG1
Retrograde regulation protein 1

1

0

High-throughput

0.458

High

744279

CHD1
Chromo domain-containing protein 1

1

0

High-throughput

0.458

High

745573

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

0

High-throughput

0.458

High

750618

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

750920

PRS7
26S proteasome regulatory subunit 7 homolog

1

0

High-throughput

0.458

High

756675

LTV1
Protein LTV1

1

0

High-throughput

0.458

High

764052

YRA2
RNA annealing protein YRA2

1

0

High-throughput

0.458

High

764053

SDS22
Protein phosphatase 1 regulatory subunit SDS22

1

0

High-throughput

0.458

High

764055

YKR18
IML2-like protein YKR018C

1

0

High-throughput

0.458

High

764057

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

0

High-throughput

0.458

High

764058

MCM7
DNA replication licensing factor MCM7

1

0

High-throughput

0.458

High

764060

RTG3
Retrograde regulation protein 3

1

0

High-throughput

0.458

High

764061

RXT2
Transcriptional regulatory protein RXT2

1

0

High-throughput

0.458

High

764063

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.458

High

764065

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

764066

RRM3
ATP-dependent DNA helicase RRM3

1

0

High-throughput

0.458

High

764067

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

0

High-throughput

0.458

High

764072

SRP14
Signal recognition particle subunit SRP14

1

0

High-throughput

0.458

High

764077

CAJ1
Protein CAJ1

1

0

High-throughput

0.458

High

764079

CAT8
Regulatory protein CAT8

1

0

High-throughput

0.458

High

764081

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.458

High

764094

ACA2
ATF/CREB activator 2

1

0

High-throughput

0.458

High

764095

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

764099

GPD2
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial

1

0

High-throughput

0.458

High

764106

NET1
Nucleolar protein NET1

1

0

High-throughput

0.458

High

764107

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.458

High

764108

NU192
Nucleoporin NUP192

1

0

High-throughput

0.458

High

764112

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

764113

UPF3
Nonsense-mediated mRNA decay protein 3

1

0

High-throughput

0.458

High

764115

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

0

High-throughput

0.458

High

764117

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.458

High

764120

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

0

High-throughput

0.458

High

764122

SGF73
SAGA complex subunit SGF73

1

0

High-throughput

0.458

High

764123

SDS23
Protein SDS23

1

0

High-throughput

0.458

High

764125

SWC4
SWR1-complex protein 4

1

0

High-throughput

0.458

High

764126

YG1B
Uncharacterized protein YGR017W

1

0

High-throughput

0.458

High

764127

YG36
Uncharacterized protein YGR126W

1

0

High-throughput

0.458

High

764128

SDA1
Protein SDA1

1

0

High-throughput

0.458

High

764129

RT102
Regulator of Ty1 transposition protein 102

1

0

High-throughput

0.458

High

764130

SPC98
Spindle pole body component SPC98

1

0

High-throughput

0.458

High

764132

NRD1
Protein NRD1

1

0

High-throughput

0.458

High

764134

SNF12
Transcription regulatory protein SNF12

1

0

High-throughput

0.458

High

764135

RHO5
GTP-binding protein RHO5

1

0

High-throughput

0.458

High

764137

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

764139

H3
Histone H3

1

0

High-throughput

0.458

High

764140

ARP4
Actin-related protein 4

1

0

High-throughput

0.458

High

764142

CDC14
Tyrosine-protein phosphatase CDC14

1

0

High-throughput

0.458

High

764143

ACS1
Acetyl-coenzyme A synthetase 1

1

0

High-throughput

0.458

High

764144

GCR2
Glycolytic genes transcriptional activator GCR2

1

0

High-throughput

0.458

High

764146

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.458

High

764150

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

0

High-throughput

0.458

High

764157

YL287
Uncharacterized protein YLR287C

1

0

High-throughput

0.458

High

764158

IMB1
Importin subunit beta-1

1

0

High-throughput

0.458

High

764159

MED10
Mediator of RNA polymerase II transcription subunit 10

1

0

High-throughput

0.458

High

764160

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.458

High

764162

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

764163

YPD1
Phosphorelay intermediate protein YPD1

1

0

High-throughput

0.458

High

764165

RIX7
Ribosome biogenesis ATPase RIX7

1

0

High-throughput

0.458

High

764167

MED7
Mediator of RNA polymerase II transcription subunit 7

1

0

High-throughput

0.458

High

764172

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

1

0

High-throughput

0.458

High

764173

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.458

High

764174

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.458

High

764177

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.458

High

764178

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.458

High

764184

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

764185

SAS5
Something about silencing protein 5

1

1

High-throughput

0.457

High

392531

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

523562

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

526362

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

741315

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

764078

XDJ1
DnaJ protein homolog XDJ1

1

2

High-throughput

0.445

High

764085

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

646365

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.438

High

764145

SPP1
COMPASS component SPP1

1

0

High-throughput

0.438

High

764166

SDO1
Ribosome maturation protein SDO1

1

0

High-throughput

0.438

High

764180

PSF1
DNA replication complex GINS protein PSF1

1

0

High-throughput

0.438

High

560577

GAL2
Galactose transporter

1

2

High-throughput

0.437

High

603447

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.437

High

672298

RV161
Reduced viability upon starvation protein 161

1

1

High-throughput

0.437

High

705756

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

1

High-throughput

0.437

High

737259

HXT3
Low-affinity glucose transporter HXT3

1

2

High-throughput

0.437

High

755071

GCN1
eIF-2-alpha kinase activator GCN1

1

1

High-throughput

0.437

High

763414

MDJ1
DnaJ homolog 1, mitochondrial

1

2

High-throughput

0.437

High

764073

HXT7
High-affinity hexose transporter HXT7

1

2

High-throughput

0.437

High

764075

TCPB
T-complex protein 1 subunit beta

1

2

High-throughput

0.437

High

764076

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.437

High

764080

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.437

High

764090

TCPE
T-complex protein 1 subunit epsilon

1

2

High-throughput

0.437

High

764091

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.437

High

764098

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.437

High

764110

BBC1
Myosin tail region-interacting protein MTI1

1

1

High-throughput

0.437

High

764133

COPA
Coatomer subunit alpha

1

1

High-throughput

0.437

High

764141

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

764151

PLP1
Phosducin-like protein 1

1

1

High-throughput

0.437

High

579168

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.407

High

408568

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.249

Low

416414

HXKA
Hexokinase-1

1

0

High-throughput

0.249

Low

452496

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.249

Low

452877

ATPA
ATP synthase subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

470028

GAL7
Galactose-1-phosphate uridylyltransferase

1

0

High-throughput

0.249

Low

478408

EI2BG
Translation initiation factor eIF2B subunit gamma

1

0

High-throughput

0.249

Low

549969

KAR1
Cell division control protein KAR1

1

0

High-throughput

0.249

Low

554685

YPK1
Serine/threonine-protein kinase YPK1

1

0

High-throughput

0.249

Low

567675

ACOX
Acyl-coenzyme A oxidase

1

0

High-throughput

0.249

Low

575427

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.249

Low

598995

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.249

Low

605304

CAP
Adenylyl cyclase-associated protein

1

0

High-throughput

0.249

Low

616412

SEC18
Vesicular-fusion protein SEC18

1

0

High-throughput

0.249

Low

618573

FAS2
Fatty acid synthase subunit alpha

1

0

High-throughput

0.249

Low

623827

MYO2
Myosin-2

1

0

High-throughput

0.249

Low

635951

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

661608

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.249

Low

698100

PEP3
Vacuolar membrane protein PEP3

1

0

High-throughput

0.249

Low

732125

COPG
Coatomer subunit gamma

1

0

High-throughput

0.249

Low

735705

VA0D
V-type proton ATPase subunit d

1

0

High-throughput

0.249

Low

736082

ARP2
Actin-related protein 2

1

0

High-throughput

0.249

Low

737446

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.249

Low

743326

FIMB
Fimbrin

1

0

High-throughput

0.249

Low

743671

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.249

Low

751184

CSE1
Importin alpha re-exporter

1

0

High-throughput

0.249

Low

751659

SEC3
Exocyst complex component SEC3

1

0

High-throughput

0.249

Low

751844

SLA2
Protein SLA2

1

0

High-throughput

0.249

Low

756614

NIC96
Nucleoporin NIC96

1

0

High-throughput

0.249

Low

757366

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.249

Low

764051

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.249

Low

764054

SRPB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.249

Low

764056

AKL1
Serine/threonine-protein kinase AKL1

1

0

High-throughput

0.249

Low

764062

AIM3
Altered inheritance of mitochondria protein 3

1

0

High-throughput

0.249

Low

764064

NPR3
Nitrogen permease regulator 3

1

0

High-throughput

0.249

Low

764068

BZZ1
Protein BZZ1

1

0

High-throughput

0.249

Low

764070

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

High-throughput

0.249

Low

764071

SEC31
Protein transport protein SEC31

1

0

High-throughput

0.249

Low

764074

END3
Actin cytoskeleton-regulatory complex protein END3

1

0

High-throughput

0.249

Low

764082

BEM2
GTPase-activating protein BEM2/IPL2

1

0

High-throughput

0.249

Low

764083

GTT3
Glutathione transferase 3

1

0

High-throughput

0.249

Low

764084

RPN3
26S proteasome regulatory subunit RPN3

1

0

High-throughput

0.249

Low

764086

NDH1
External NADH-ubiquinone oxidoreductase 1, mitochondrial

1

0

High-throughput

0.249

Low

764088

PEP8
Carboxypeptidase Y-deficient protein 8

1

0

High-throughput

0.249

Low

764089

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.249

Low

764092

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.249

Low

764093

GVP36
Protein GVP36

1

0

High-throughput

0.249

Low

764096

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.249

Low

764097

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.249

Low

764101

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.249

Low

764103

COPD
Coatomer subunit delta

1

0

High-throughput

0.249

Low

764104

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

764105

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

764109

AP3S
AP-3 complex subunit sigma

1

0

High-throughput

0.249

Low

764111

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.249

Low

764114

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

764118

NU188
Nucleoporin NUP188

1

0

High-throughput

0.249

Low

764119

NBP1
NAP1-binding protein

1

0

High-throughput

0.249

Low

764121

MLC1
Myosin light chain 1

1

0

High-throughput

0.249

Low

764131

SUCA
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

764138

DNM1
Dynamin-related protein DNM1

1

0

High-throughput

0.249

Low

764148

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.249

Low

764149

SRC1
Inner nuclear membrane protein SRC1

1

0

High-throughput

0.249

Low

764152

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

764153

IVY1
Protein IVY1

1

0

High-throughput

0.249

Low

764154

RTN1
Reticulon-like protein 1

1

0

High-throughput

0.249

Low

764155

EIS1
Eisosome protein 1

1

0

High-throughput

0.249

Low

764156

RQC1
Ribosome quality control complex subunit 1

1

0

High-throughput

0.249

Low

764161

GIC2
GTPase-interacting component 2

1

0

High-throughput

0.249

Low

764164

PUF3
mRNA-binding protein PUF3

1

0

High-throughput

0.249

Low

764168

RPN8
26S proteasome regulatory subunit RPN8

1

0

High-throughput

0.249

Low

764169

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

High-throughput

0.249

Low

764170

YP225
Protein PBDC1 homolog

1

0

High-throughput

0.249

Low

764175

HSP42
Heat shock protein 42

1

0

High-throughput

0.249

Low

764176

BBP1
Spindle pole component BBP1

1

0

High-throughput

0.249

Low

764179

TCB1
Tricalbin-1

1

0

High-throughput

0.249

Low

764181

AVL9
Late secretory pathway protein AVL9

1

0

High-throughput

0.249

Low

764183

YI002
Uncharacterized protein YIL002W-A

1

0

High-throughput

0.249

Low

764069

PET8
Putative mitochondrial carrier protein PET8

1

0

High-throughput

0.238

Low

764100

ZIM17
Mitochondrial protein import protein ZIM17

1

0

High-throughput

0.238

Low

671613

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025