Protein: ISCS
Cysteine desulfurase IscS (EC 2.8.1.7) (NifS protein homolog) (ThiI transpersulfidase) (TusA transpersulfidase)

Gene: ISCS
Organism: Escherichia coli K-12
Interactions: 49
UniProt ID: P0A6B7

Gene Ontology (top 5):
GO:0002143 - tRNA wobble position uridine thiolation
GO:0002937 - tRNA 4-thiouridine biosynthesis
GO:0005829 - cytosol
GO:0009000 - selenocysteine lyase activity
GO:0009228 - thiamine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

457391

ISCU
Iron-sulfur cluster assembly scaffold protein IscU

4

7

Small-scale

0.915

High

457380

TUSA
Sulfur carrier protein TusA

4

1

Small-scale

0.903

High

457404

CYAY
Iron-sulfur cluster assembly protein CyaY

1

4

Small-scale

0.724

High

457408

FDHD
Sulfur carrier protein FdhD

3

0

Small-scale

0.645

High

457383

FER
2Fe-2S ferredoxin

2

1

Small-scale

0.633

High

457325

ACP
Acyl carrier protein

1

2

Small-scale

0.575

High

393691

APPY
HTH-type transcriptional regulator AppY

1

1

High-throughput

0.536

High

457379

RS9
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

457382

DLDH
Dihydrolipoyl dehydrogenase

1

1

High-throughput

0.536

High

457388

YCHF
Ribosome-binding ATPase YchF

1

1

High-throughput

0.536

High

457402

NADE
NH(3)-dependent NAD(+) synthetase

1

1

High-throughput

0.536

High

421156

PROA
Gamma-glutamyl phosphate reductase

1

0

High-throughput

0.513

High

457376

GREA
Transcription elongation factor GreA

1

0

High-throughput

0.513

High

457381

RRAA
Regulator of ribonuclease activity A

1

0

High-throughput

0.513

High

457387

NAPC
Cytochrome c-type protein NapC

1

0

High-throughput

0.513

High

457389

HCAC
3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit

1

0

High-throughput

0.513

High

457390

GNSA
Protein GnsA

1

0

High-throughput

0.513

High

457392

YMJA
Uncharacterized protein YmjA

1

0

High-throughput

0.513

High

457394

RIMO
Ribosomal protein uS12 methylthiotransferase RimO

1

0

High-throughput

0.513

High

457396

NUSG
Transcription termination/antitermination protein NusG

1

0

High-throughput

0.513

High

457399

MURF
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

1

0

High-throughput

0.513

High

457406

PANB
3-methyl-2-oxobutanoate hydroxymethyltransferase

1

0

High-throughput

0.513

High

457416

BAER
Transcriptional regulatory protein BaeR

1

0

High-throughput

0.513

High

457378

PYRE
Orotate phosphoribosyltransferase

1

0

High-throughput

0.493

High

449149

RHAR
HTH-type transcriptional activator RhaR

1

1

High-throughput

0.489

High

457411

MENE
2-succinylbenzoate--CoA ligase

1

1

High-throughput

0.489

High

457377

DNAK
Chaperone protein DnaK

1

5

High-throughput

0.484

High

457386

CISY
Citrate synthase

1

1

High-throughput

0.479

High

457393

YEBG
Uncharacterized protein YebG

1

0

High-throughput

0.458

High

457417

NPD
NAD-dependent protein deacylase

1

3

High-throughput

0.442

High

457405

YHHH
Uncharacterized protein YhhH

1

0

High-throughput

0.282

High

340985

BGAL
Beta-galactosidase

1

0

High-throughput

0.279

Low

457375

PNCC
Nicotinamide-nucleotide amidohydrolase PncC

1

0

High-throughput

0.279

Low

457384

YBEL
Uncharacterized protein YbeL

1

0

High-throughput

0.279

Low

457385

ATPD
ATP synthase subunit delta

1

0

High-throughput

0.279

Low

457397

RNK
Regulator of nucleoside diphosphate kinase

1

0

High-throughput

0.279

Low

457398

LPXB
Lipid-A-disaccharide synthase

1

0

High-throughput

0.279

Low

457400

BIOC
Malonyl-[acyl-carrier protein] O-methyltransferase

1

0

High-throughput

0.279

Low

457401

MIAA
tRNA dimethylallyltransferase

1

0

High-throughput

0.279

Low

457409

HOFQ
DNA utilization protein HofQ

1

0

High-throughput

0.279

Low

457410

RLMA
23S rRNA

1

0

High-throughput

0.279

Low

457412

SPRT
Protein SprT

1

0

High-throughput

0.279

Low

457413

YECH
Uncharacterized protein YecH

1

0

High-throughput

0.279

Low

457414

YDBH
Uncharacterized protein YdbH

1

0

High-throughput

0.279

Low

457415

PROXY
Multifunctional Ser/Thr-tRNA deacylase ProXp-y

1

0

High-throughput

0.279

Low

457418

QUEC
7-cyano-7-deazaguanine synthase

1

0

High-throughput

0.279

Low

457395

MLTD
Membrane-bound lytic murein transglycosylase D

1

0

High-throughput

0.253

Low

457403

HYPD
Hydrogenase maturation factor HypD

1

0

High-throughput

0.249

Low

457407

YEDD
Uncharacterized lipoprotein YedD

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024