Protein: DPH4
Diphthamide biosynthesis protein 4 (J protein type 3)

Gene: DPH4, JJJ3
Organism: Saccharomyces cerevisiae S288C
Interactions: 74
UniProt ID: P47138

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0008198 - ferrous iron binding
GO:0017183 - protein histidyl modification to diphthamide

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

440855

KIN28
Serine/threonine-protein kinase KIN28

1

7

High-throughput

0.647

High

548913

SCH9
Serine/threonine-protein kinase SCH9

1

8

High-throughput

0.647

High

602546

PHO85
Cyclin-dependent protein kinase PHO85

1

3

High-throughput

0.647

High

673712

KCC4
Probable serine/threonine-protein kinase KCC4

1

7

High-throughput

0.647

High

745279

ELM1
Serine/threonine-protein kinase ELM1

1

1

High-throughput

0.647

High

865957

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

17

High-throughput

0.647

High

865958

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

9

High-throughput

0.647

High

865973

PKH2
Serine/threonine-protein kinase PKH2

1

17

High-throughput

0.647

High

865959

PKH3
Serine/threonine-protein kinase PKH3

1

11

High-throughput

0.579

High

673742

SSK22
Serine/threonine-protein kinase SSK22

1

14

High-throughput

0.575

High

676133

MAS5
Mitochondrial protein import protein MAS5

1

19

High-throughput

0.575

High

509625

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

20

High-throughput

0.501

High

865953

CARME
Carnosine N-methyltransferase

1

1

High-throughput

0.494

High

865661

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.479

High

825360

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

1

High-throughput

0.457

High

402232

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

2

High-throughput

0.445

High

415233

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.445

High

448983

TOP2
DNA topoisomerase 2

1

4

High-throughput

0.445

High

458964

LYS2
L-2-aminoadipate reductase

1

2

High-throughput

0.445

High

542977

CDC24
Cell division control protein 24

1

2

High-throughput

0.445

High

638109

OSM1
Fumarate reductase 2

1

2

High-throughput

0.445

High

702260

YJU2
Splicing factor YJU2

1

1

High-throughput

0.445

High

740674

CBS
Cystathionine beta-synthase

1

2

High-throughput

0.445

High

747740

SMC1
Structural maintenance of chromosomes protein 1

1

4

High-throughput

0.445

High

748139

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

1

High-throughput

0.445

High

750863

PRS6B
26S proteasome regulatory subunit 6B homolog

1

2

High-throughput

0.445

High

757931

YEL1
Guanine-nucleotide exchange factor YEL1

1

1

High-throughput

0.445

High

781717

SA190
SIT4-associating protein SAP190

1

2

High-throughput

0.445

High

791912

AAP1
Alanine/arginine aminopeptidase

1

4

High-throughput

0.445

High

801153

MED31
Mediator of RNA polymerase II transcription subunit 31

1

1

High-throughput

0.445

High

806041

KEL1
Kelch repeat-containing protein 1

1

5

High-throughput

0.445

High

817343

TPA1
Prolyl 3,4-dihydroxylase TPA1

1

1

High-throughput

0.445

High

825160

NU159
Nucleoporin NUP159

1

3

High-throughput

0.445

High

865949

DXO
Decapping nuclease RAI1

1

2

High-throughput

0.445

High

865950

SNT2
E3 ubiquitin-protein ligase SNT2

1

5

High-throughput

0.445

High

865955

SEN1
Helicase SEN1

1

2

High-throughput

0.445

High

865960

PDS5
Sister chromatid cohesion protein PDS5

1

2

High-throughput

0.445

High

865961

APC4
Anaphase-promoting complex subunit 4

1

1

High-throughput

0.445

High

865962

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.445

High

865966

SKG3
Protein SKG3

1

1

High-throughput

0.445

High

865967

DCK1
DOCK-like protein 1

1

2

High-throughput

0.445

High

865974

SMC4
Structural maintenance of chromosomes protein 4

1

4

High-throughput

0.445

High

865977

HAT1
Histone acetyltransferase type B catalytic subunit

1

1

High-throughput

0.445

High

865978

AHA1
Hsp90 co-chaperone AHA1

1

2

High-throughput

0.445

High

693224

URK1
Uridine kinase

1

0

High-throughput

0.426

High

748300

SPT4
Transcription elongation factor SPT4

1

0

High-throughput

0.426

High

814106

GIP4
GLC7-interacting protein 4

1

0

High-throughput

0.426

High

818419

DDI1
DNA damage-inducible protein 1

1

0

High-throughput

0.426

High

865963

RPN7
26S proteasome regulatory subunit RPN7

1

0

High-throughput

0.426

High

865965

TOS4
Protein TOS4

1

0

High-throughput

0.426

High

865970

TSR2
Pre-rRNA-processing protein TSR2

1

0

High-throughput

0.426

High

865972

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

0

High-throughput

0.426

High

360670

COX2
Cytochrome c oxidase subunit 2

1

1

High-throughput

0.407

High

481904

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.407

High

605112

TPM1
Tropomyosin-1

1

1

High-throughput

0.407

High

673666

USO1
Intracellular protein transport protein USO1

1

4

High-throughput

0.407

High

753250

MFT1
THO complex subunit MFT1

1

1

High-throughput

0.407

High

825010

TAO3
Cell morphogenesis protein PAG1

1

1

High-throughput

0.407

High

836291

BNI1
Protein BNI1

1

4

High-throughput

0.407

High

849530

GCN20
Protein GCN20

1

4

High-throughput

0.407

High

865951

COPA
Coatomer subunit alpha

1

8

High-throughput

0.407

High

865952

YN97
Uncharacterized protein YNR068C

1

1

High-throughput

0.407

High

865964

YL173
Putative uncharacterized protein YLR173W

1

1

High-throughput

0.407

High

865968

TAZ
Tafazzin

1

1

High-throughput

0.407

High

865971

ADY3
Accumulates dyads protein 3

1

6

High-throughput

0.407

High

865975

CRC1
Mitochondrial carnitine carrier

1

7

High-throughput

0.407

High

865976

RGT2
High glucose sensor RGT2

1

2

High-throughput

0.407

High

605910

HPR1
THO complex subunit HPR1

1

0

High-throughput

0.232

Low

746708

TRS65
Trafficking protein particle complex II-specific subunit 65

1

0

High-throughput

0.232

Low

813579

VPS8
Vacuolar protein sorting-associated protein 8

1

0

High-throughput

0.232

Low

865954

YNI9
Putative uncharacterized protein YNL089C

1

0

High-throughput

0.232

Low

865956

RT23
Small ribosomal subunit protein mS29

1

0

High-throughput

0.232

Low

865969

GIC2
GTPase-interacting component 2

1

0

High-throughput

0.232

Low

865979

YO019
Uncharacterized protein YOR019W

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025