Protein: RFA3
Replication factor A protein 3 (RF-A) (Replication protein A 13 kDa subunit)

Gene: RFA3
Organism: Saccharomyces cerevisiae S288C
Interactions: 91
UniProt ID: P26755

Gene Ontology (top 5):
GO:0000722 - telomere maintenance via recombination
GO:0000723 - telomere maintenance
GO:0000724 - double-strand break repair via homologous recombination
GO:0000781 - chromosome, telomeric region
GO:0000794 - condensed nuclear chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

647712

RFA1
Replication factor A protein 1

18

0

Small-scale

0.935

High

688722

RFA2
Replication factor A protein 2

10

0

Small-scale

0.924

High

688796

RT105
Regulator of Ty1 transposition protein 105

4

0

Small-scale

0.672

High

448435

RAD52
DNA repair and recombination protein RAD52

4

0

Small-scale

0.668

High

688791

ATR
Serine/threonine-protein kinase MEC1

4

0

Small-scale

0.667

High

688779

RFA3
Replication factor A protein 3

1

0

Small-scale

0.589

High

688794

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2

2

0

High-throughput

0.576

High

688821

LCD1
DNA damage checkpoint protein LCD1

2

0

Small-scale

0.569

High

688816

MSH6
DNA mismatch repair protein MSH6

2

1

High-throughput

0.567

High

672001

MSH3
DNA mismatch repair protein MSH3

1

1

High-throughput

0.536

High

688798

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

High-throughput

0.504

High

613501

ADT3
ADP,ATP carrier protein 3

1

1

High-throughput

0.489

High

688797

GPP2
Glycerol-1-phosphate phosphohydrolase 2

1

1

High-throughput

0.489

High

688802

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

1

High-throughput

0.489

High

675311

RAD51
DNA repair protein RAD51

1

0

Small-scale

0.480

High

419372

H2A1
Histone H2A.1

1

1

High-throughput

0.479

High

419628

H2A2
Histone H2A.2

1

1

High-throughput

0.479

High

688782

MCM4
DNA replication licensing factor MCM4

1

0

Small-scale

0.458

High

688789

BDF1
Bromodomain-containing factor 1

1

0

Small-scale

0.458

High

688809

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

Small-scale

0.458

High

688815

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.458

High

688818

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

688819

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

688822

POB3
FACT complex subunit POB3

1

0

High-throughput

0.458

High

366957

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.457

High

416389

HXKA
Hexokinase-1

1

1

High-throughput

0.457

High

452838

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.457

High

531260

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.457

High

607735

HXKG
Glucokinase-1

1

1

High-throughput

0.457

High

613534

ADT2
ADP,ATP carrier protein 2

1

1

High-throughput

0.457

High

621347

METK2
S-adenosylmethionine synthase 2

1

1

High-throughput

0.457

High

688827

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

1

High-throughput

0.457

High

688828

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

1

High-throughput

0.457

High

380994

H2B1
Histone H2B.1

1

1

High-throughput

0.437

High

381430

H2B2
Histone H2B.2

1

1

High-throughput

0.437

High

523223

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.407

High

526063

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.407

High

544013

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.407

High

688787

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.407

High

688830

CMR1
DNA damage-binding protein CMR1

2

0

High-throughput

0.318

High

688812

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

2

0

High-throughput

0.310

High

688823

RNH1
Ribonuclease H

2

0

High-throughput

0.307

High

688800

MPH1
ATP-dependent DNA helicase MPH1

2

0

Small-scale

0.305

High

688801

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.305

High

677712

VAC17
vacuole-related protein 17

2

0

Small-scale

0.295

High

471379

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.279

Low

688786

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.279

Low

688790

PGM2
Phosphoglucomutase 2

1

0

High-throughput

0.279

Low

688795

HXT7
High-affinity hexose transporter HXT7

1

0

High-throughput

0.279

Low

688803

MMM1
Maintenance of mitochondrial morphology protein 1

1

0

Small-scale

0.279

Low

688806

YJ9I
Uncharacterized protein YJR141W

1

0

High-throughput

0.279

Low

688811

EF3B
Elongation factor 3B

1

0

High-throughput

0.279

Low

688817

WDR59
Maintenance of telomere capping protein 5

1

0

High-throughput

0.279

Low

688824

IMB1
Importin subunit beta-1

1

0

High-throughput

0.279

Low

367365

CISY1
Citrate synthase, mitochondrial

1

0

High-throughput

0.261

Low

368608

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.261

Low

386594

TBB
Tubulin beta chain

1

0

High-throughput

0.261

Low

392331

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.261

Low

394295

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.261

Low

408297

GAL1
Galactokinase

1

0

High-throughput

0.261

Low

408559

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

555024

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.261

Low

590556

HSP26
Heat shock protein 26

1

0

High-throughput

0.261

Low

597057

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.261

Low

626623

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.261

Low

688781

BMH1
Protein BMH1

1

0

High-throughput

0.261

Low

688788

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.261

Low

688793

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.261

Low

688804

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.261

Low

381910

H4
Histone H4

1

0

High-throughput

0.249

Low

682177

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.249

Low

688780

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

688783

HS104
Heat shock protein 104

1

0

High-throughput

0.249

Low

688784

BTAF1
TATA-binding protein-associated factor MOT1

1

0

Small-scale

0.249

Low

688785

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

688792

INCE
Inner centromere protein SLI15

1

0

Small-scale

0.249

Low

688799

VPS27
Vacuolar protein sorting-associated protein 27

1

0

High-throughput

0.249

Low

688805

BIR1
Chromosomal passenger complex protein BIR1

1

0

Small-scale

0.249

Low

688807

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

688808

GIS2
Zinc finger protein GIS2

1

0

High-throughput

0.249

Low

688810

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.249

Low

688813

H3
Histone H3

1

0

High-throughput

0.249

Low

688814

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.249

Low

688820

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

688825

NHEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.249

Low

688826

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

688829

SMC4
Structural maintenance of chromosomes protein 4

1

0

Small-scale

0.249

Low

528799

RLA3
Large ribosomal subunit protein P1B

1

0

High-throughput

0.238

Low

553953

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.232

Low

653829

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025