Protein: IPYR
Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)

Gene: IPYR, IPP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 119
UniProt ID: P00817

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004427 - inorganic diphosphate phosphatase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006796 - phosphate-containing compound metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366778

IPYR2
Inorganic pyrophosphatase, mitochondrial

3

6

High-throughput

0.830

High

366738

IPYR
Inorganic pyrophosphatase

2

6

Small-scale

0.757

High

366823

ROM2
RHO1 GDP-GTP exchange protein 2

4

2

High-throughput

0.694

High

366849

RGL1
RHO1 GEF localizing protein 1

4

0

High-throughput

0.664

High

366840

TUS1
Rho1 guanine nucleotide exchange factor TUS1

3

2

High-throughput

0.662

High

366739

HSP82
ATP-dependent molecular chaperone HSP82

3

2

High-throughput

0.633

High

366748

CALM
Calmodulin

2

0

Small-scale

0.612

High

366832

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

2

1

Small-scale

0.611

High

366740

EF1A
Elongation factor 1-alpha

2

1

High-throughput

0.588

High

366818

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

366758

SSB1
Ribosome-associated molecular chaperone SSB1

2

2

High-throughput

0.552

High

366828

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

366853

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.529

High

366768

DBP4
ATP-dependent RNA helicase HCA4

1

1

High-throughput

0.515

High

366793

SHB17
Sedoheptulose 1,7-bisphosphatase

1

1

High-throughput

0.515

High

366821

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

2

High-throughput

0.515

High

366852

GST2
Glutathione S-transferase 2

1

2

High-throughput

0.515

High

366624

ARGI
Arginase

1

0

High-throughput

0.513

High

366747

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.513

High

366770

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.513

High

366781

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

366791

SLD2
DNA replication regulator SLD2

1

0

High-throughput

0.513

High

366831

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

High-throughput

0.513

High

366772

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

1

High-throughput

0.501

High

366804

RSP5
E3 ubiquitin-protein ligase RSP5

1

2

High-throughput

0.501

High

366767

FKBP
FK506-binding protein 1

1

4

High-throughput

0.500

High

366784

FIMB
Fimbrin

1

2

High-throughput

0.500

High

366829

RHO5
GTP-binding protein RHO5

1

7

High-throughput

0.500

High

366813

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

0

High-throughput

0.493

High

366816

SA185
SIT4-associating protein SAP185

1

0

High-throughput

0.493

High

366776

RL16A
Large ribosomal subunit protein uL13A

1

2

High-throughput

0.489

High

366806

RL13B
Large ribosomal subunit protein eL13B

1

1

High-throughput

0.489

High

366765

MYO2
Myosin-2

1

1

Small-scale

0.481

High

366814

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.481

High

366834

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.481

High

366754

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.480

High

366841

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.480

High

366766

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.479

High

366746

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

366751

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

4

Small-scale

0.479

High

366762

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

366771

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

366773

SIS1
Protein SIS1

1

1

High-throughput

0.479

High

366774

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

366775

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

366779

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

366780

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.479

High

366782

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

366797

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

366825

ROM1
RHO1 GDP-GTP exchange protein 1

1

4

High-throughput

0.479

High

366836

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

366837

GIS1
Transcriptional activator/repressor GIS1

1

2

High-throughput

0.479

High

149443

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

366741

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

0

High-throughput

0.458

High

366742

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

366744

HXKA
Hexokinase-1

1

0

Small-scale

0.458

High

366769

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

366790

MSN2
Zinc finger protein MSN2

1

0

High-throughput

0.458

High

366792

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

366795

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

0

High-throughput

0.458

High

366798

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

366799

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

366802

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.458

High

366815

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

366820

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

366827

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

366833

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

366838

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

366839

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

366846

SGO1
Shugoshin

1

0

High-throughput

0.458

High

366755

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

366756

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

366763

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.445

High

366783

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

366788

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

366805

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

366810

6P21
6-phosphofructo-2-kinase 1

1

1

High-throughput

0.445

High

366822

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

2

High-throughput

0.445

High

366843

BRE1
E3 ubiquitin-protein ligase BRE1

1

1

High-throughput

0.445

High

366850

RL7B
Large ribosomal subunit protein uL30B

1

1

High-throughput

0.445

High

366785

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

366789

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

366812

MLP2
Protein MLP2

1

1

High-throughput

0.437

High

366847

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

366851

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.437

High

366757

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.426

High

366759

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.426

High

366760

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.426

High

366809

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.426

High

366811

YIQ1
Uncharacterized protein YIL161W

1

0

High-throughput

0.426

High

366819

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

366835

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.426

High

366844

ACK1
Activator of C kinase protein 1

3

0

High-throughput

0.345

High

366826

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

0

High-throughput

0.307

High

366796

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.279

Low

366801

RS14B
Small ribosomal subunit protein uS11B

1

0

High-throughput

0.279

Low

366808

NTA1
Protein N-terminal amidase

1

0

High-throughput

0.279

Low

366807

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

High-throughput

0.261

Low

366817

BNI1
Protein BNI1

1

0

High-throughput

0.261

Low

366845

AUS1
ATP-dependent permease AUS1

1

0

High-throughput

0.261

Low

366786

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.261

Low

366824

SEH1
Nucleoporin SEH1

1

0

High-throughput

0.261

Low

366842

LEC1
PX domain-containing protein LEC1

1

0

Small-scale

0.251

Low

366743

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

366745

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

366749

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

366750

RL27A
Large ribosomal subunit protein eL27A

1

0

High-throughput

0.249

Low

366752

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

366753

RL2A
Large ribosomal subunit protein uL2A

1

0

High-throughput

0.249

Low

366764

TPM1
Tropomyosin-1

1

0

Small-scale

0.249

Low

366777

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

366787

YPT7
Ypt/Rab-type GTPase YPT7

1

0

Small-scale

0.249

Low

366794

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

366803

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

366830

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

366848

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

366761

RS17B
Small ribosomal subunit protein eS17B

1

0

High-throughput

0.232

Low

366800

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025