Protein: IL6
Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)

Gene: IL6
Organism: Homo sapiens
Interactions: 22
UniProt ID: P05231

Gene Ontology (top 5):
GO:0001781 - neutrophil apoptotic process
GO:0002314 - germinal center B cell differentiation
GO:0002384 - hepatic immune response
GO:0002446 - neutrophil mediated immunity
GO:0002548 - monocyte chemotaxis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

426972

IL6RA
Interleukin-6 receptor subunit alpha

13

2

Small-scale

0.982

High

426977

IL6RB
Interleukin-6 receptor subunit beta

3

1

Small-scale

0.845

High

426980

TF65
Transcription factor p65

6

4

Small-scale

0.721

High

426988

SORL
Sortilin-related receptor

1

1

Small-scale

0.681

High

426975

CEBPB
CCAAT/enhancer-binding protein beta

2

2

Small-scale

0.584

High

426981

REL
Proto-oncogene c-Rel

2

4

Small-scale

0.584

High

426990

SORT
Sortilin

1

1

Small-scale

0.561

High

426991

SH3G2
Endophilin-A1

1

0

High-throughput

0.518

High

426985

ZC12A
Endoribonuclease ZC3H12A

1

0

Small-scale

0.480

High

426976

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

5

Small-scale

0.479

High

426984

EP300
Histone acetyltransferase p300

1

1

Small-scale

0.479

High

426986

TET2
Methylcytosine dioxygenase TET2

1

1

Small-scale

0.479

High

426989

CBP
CREB-binding protein

1

1

Small-scale

0.479

High

369583

A2MG
Alpha-2-macroglobulin

1

0

Small-scale

0.458

High

388480

CRP

1

0

Small-scale

0.458

High

426973

IRF1
Interferon regulatory factor 1

1

0

Small-scale

0.458

High

426974

ONCM
Oncostatin-M

1

0

Small-scale

0.458

High

426978

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.458

High

426983

SUH
Recombining binding protein suppressor of hairless

1

0

Small-scale

0.458

High

426982

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

High-throughput

0.438

High

426987

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

Small-scale

0.426

High

426979

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025