Protein: ZC12A
Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A)

Gene: ZC12A, ZC3H12A
Organism: Homo sapiens
Interactions: 32
UniProt ID: Q5D1E8

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000932 - P-body
GO:0001525 - angiogenesis
GO:0001933 - negative regulation of protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1203978

ZC12A
Endoribonuclease ZC3H12A

2

1

Small-scale

0.768

High

58638

ZC12D
Probable ribonuclease ZC3H12D

1

1

Small-scale

0.713

High

1203991

NEMO
NF-kappa-B essential modulator

2

2

Small-scale

0.641

High

508088

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

4

Small-scale

0.629

High

1203986

AHSP
Alpha-hemoglobin-stabilizing protein

2

0

High-throughput

0.618

High

1203989

FBW1A
F-box/WD repeat-containing protein 1A

3

0

Small-scale

0.618

High

1203982

TANK
TRAF family member-associated NF-kappa-B activator

2

0

Small-scale

0.613

High

1131045

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

2

0

Small-scale

0.595

High

210191

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

1

High-throughput

0.586

High

1014531

SMAD3
Mothers against decapentaplegic homolog 3

1

0

High-throughput

0.549

High

1203983

TRI63
E3 ubiquitin-protein ligase TRIM63

1

4

High-throughput

0.541

High

1203985

TRI55
Tripartite motif-containing protein 55

1

4

High-throughput

0.541

High

1096562

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.486

High

426985

IL6
Interleukin-6

1

0

Small-scale

0.480

High

1161296

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.480

High

167912

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.479

High

172898

XPO1
Exportin-1

1

3

High-throughput

0.479

High

1094907

TRAF3
TNF receptor-associated factor 3

1

6

Small-scale

0.479

High

1122503

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

Small-scale

0.479

High

1129145

IRF3
Interferon regulatory factor 3

1

2

Small-scale

0.479

High

1203987

TBK1
Serine/threonine-protein kinase TBK1

1

2

Small-scale

0.479

High

1203988

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

1203990

TRAF6
TNF receptor-associated factor 6

1

7

Small-scale

0.479

High

910932

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.460

High

1067423

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.460

High

1203984

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

0

High-throughput

0.460

High

1013783

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.458

High

1203979

MAVS
Mitochondrial antiviral-signaling protein

1

0

Small-scale

0.458

High

1203981

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1203980

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

3

0

High-throughput

0.352

High

948155

DJB13
DnaJ homolog subfamily B member 13

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025