Protein: IL6RA
Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)]

Gene: IL6RA, IL6R
Organism: Homo sapiens
Interactions: 24
UniProt ID: P08887

Gene Ontology (top 5):
GO:0002384 - hepatic immune response
GO:0002446 - neutrophil mediated immunity
GO:0002548 - monocyte chemotaxis
GO:0002690 - positive regulation of leukocyte chemotaxis
GO:0004896 - cytokine receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

426972

IL6
Interleukin-6

13

2

Small-scale

0.982

High

477100

IL6RB
Interleukin-6 receptor subunit beta

6

15

Small-scale

0.932

High

477099

CNTF
Ciliary neurotrophic factor

2

6

Small-scale

0.812

High

186498

TRI18
E3 ubiquitin-protein ligase Midline-1

2

17

High-throughput

0.811

High

477108

SORL
Sortilin-related receptor

1

12

Small-scale

0.724

High

477112

COPRS
Coordinator of PRMT5 and differentiation stimulator

2

0

High-throughput

0.602

High

348273

QORL1
Quinone oxidoreductase-like protein 1

2

1

High-throughput

0.574

High

477102

CETN2
Centrin-2

2

1

High-throughput

0.574

High

477107

TBCK
TBC domain-containing protein kinase-like protein

2

2

High-throughput

0.574

High

477109

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

2

9

High-throughput

0.553

High

458245

ADRB2
Beta-2 adrenergic receptor

1

3

Small-scale

0.552

High

477103

FP100
Fanconi anemia core complex-associated protein 100

1

1

High-throughput

0.489

High

477098

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.479

High

477101

STAT3
Signal transducer and activator of transcription 3

1

16

Small-scale

0.479

High

477114

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

0

Small-scale

0.458

High

477110

ZFP91
E3 ubiquitin-protein ligase ZFP91

1

2

Small-scale

0.437

High

477115

FBX2
F-box only protein 2

1

15

Small-scale

0.437

High

477104

PPR21
Protein phosphatase 1 regulatory subunit 21

2

0

High-throughput

0.328

High

477106

FANCB
Fanconi anemia group B protein

2

0

High-throughput

0.328

High

477111

FERY3
Ferry endosomal RAB5 effector complex subunit 3

2

0

High-throughput

0.328

High

477113

FANCL
E3 ubiquitin-protein ligase FANCL

2

0

High-throughput

0.328

High

128373

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

Small-scale

0.301

High

477105

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

1

0

High-throughput

0.279

Low

477097

GLI2
Zinc finger protein GLI2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025