Protein: PEP5
E3 ubiquitin-protein ligase PEP5 (EC 2.3.2.27) (Carboxypeptidase Y-deficient protein 5) (Histone E3 ligase PEP5) (RING-type E3 ubiquitin transferase PEP5) (Vacuolar biogenesis protein END1) (Vacuolar morphogenesis protein 1) (Vacuolar protein sorting-associated protein 11) (Vacuolar protein-targeting protein 11)

Gene: PEP5
Organism: Saccharomyces cerevisiae S288C
Interactions: 50
UniProt ID: P12868

Gene Ontology (top 5):
GO:0000329 - fungal-type vacuole membrane
GO:0005768 - endosome
GO:0005829 - cytosol
GO:0006886 - intracellular protein transport
GO:0006895 - Golgi to endosome transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

556605

VPS41
Vacuolar protein sorting-associated protein 41

15

4

Small-scale

0.762

High

556621

VAM6
Vacuolar morphogenesis protein 6

13

10

Small-scale

0.761

High

556592

PEP3
Vacuolar membrane protein PEP3

9

10

Small-scale

0.760

High

556587

VPS33
Vacuolar protein sorting-associated protein 33

11

3

Small-scale

0.757

High

556606

VPS8
Vacuolar protein sorting-associated protein 8

9

1

Small-scale

0.752

High

556618

VPS16
Vacuolar protein sorting-associated protein 16

6

2

Small-scale

0.738

High

556597

VAM7
Vacuolar morphogenesis protein 7

6

1

Small-scale

0.730

High

556589

VPS3
Vacuolar protein sorting-associated protein 3

8

0

Small-scale

0.714

High

556599

YPT7
Ypt/Rab-type GTPase YPT7

4

2

Small-scale

0.692

High

556625

VAM3
Syntaxin VAM3

4

5

Small-scale

0.689

High

556585

PEP5
E3 ubiquitin-protein ligase PEP5

2

1

Small-scale

0.600

High

556595

PEP7
Vacuolar segregation protein PEP7

2

0

Small-scale

0.575

High

556586

UBC4
Ubiquitin-conjugating enzyme E2 4

1

1

Small-scale

0.561

High

556608

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

High-throughput

0.552

High

556613

MON1
Vacuolar fusion protein MON1

1

2

Small-scale

0.508

High

556600

VPS21
Vacuolar protein sorting-associated protein 21

1

4

Small-scale

0.481

High

556601

YPT52
GTP-binding protein YPT52

1

3

Small-scale

0.481

High

556611

YPT11
GTP-binding protein YPT11

1

1

Small-scale

0.481

High

556603

CCZ1
Vacuolar fusion protein CCZ1

1

0

Small-scale

0.480

High

556607

KC13
Casein kinase I homolog 3

1

0

Small-scale

0.480

High

556622

AP3D
AP-3 complex subunit delta

1

0

Small-scale

0.480

High

556614

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.479

High

434765

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

454827

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

514411

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

556588

VPS34
Phosphatidylinositol 3-kinase VPS34

1

0

High-throughput

0.458

High

556590

BPH1
Beige protein homolog 1

1

0

High-throughput

0.458

High

556593

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

556596

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

556612

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

556616

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

556617

BECN1
Vacuolar protein sorting-associated protein 30

1

0

High-throughput

0.458

High

556619

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

556620

VTI1
t-SNARE VTI1

1

0

Small-scale

0.458

High

556624

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

543631

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

556591

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

525774

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

381830

H4
Histone H4

1

0

Small-scale

0.292

High

506424

U5072
UPF0507 protein YML002W

1

0

Small-scale

0.251

Low

556598

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

556602

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

556609

MHP1
MAP-homologous protein 1

1

0

High-throughput

0.249

Low

556615

H3
Histone H3

1

0

Small-scale

0.249

Low

556623

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

556626

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.249

Low

556594

PP12
Serine/threonine-protein phosphatase PP1-2

1

0

High-throughput

0.232

Low

556604

KPR3
Ribose-phosphate pyrophosphokinase 3

1

0

High-throughput

0.232

Low

556610

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025