Protein: KPR3
Ribose-phosphate pyrophosphokinase 3 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 3)

Gene: KPR3, PRS3
Organism: Saccharomyces cerevisiae S288C
Interactions: 82
UniProt ID: P38689

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0002189 - ribose phosphate diphosphokinase complex
GO:0004749 - ribose phosphate diphosphokinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

746727

KPR1
Ribose-phosphate pyrophosphokinase 1

8

18

Small-scale

0.967

High

801798

KPR5
Ribose-phosphate pyrophosphokinase 5

2

17

High-throughput

0.793

High

792598

KPR4
Ribose-phosphate pyrophosphokinase 4

2

18

Small-scale

0.754

High

801774

KPR3
Ribose-phosphate pyrophosphokinase 3

1

17

High-throughput

0.698

High

800651

KPR2
Ribose-phosphate pyrophosphokinase 2

1

17

High-throughput

0.618

High

800605

RIM11
Serine/threonine-protein kinase RIM11/MSD1

2

4

Small-scale

0.614

High

579320

HSC82
ATP-dependent molecular chaperone HSC82

2

5

High-throughput

0.611

High

801779

SSB2
Ribosome-associated molecular chaperone SSB2

2

10

High-throughput

0.552

High

486158

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.536

High

626715

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.536

High

801792

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

4

High-throughput

0.536

High

670659

SIS1
Protein SIS1

2

5

High-throughput

0.521

High

569774

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.513

High

801782

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.513

High

801788

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

575443

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

1

High-throughput

0.489

High

734087

EF2
Elongation factor 2

1

4

High-throughput

0.489

High

747335

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.489

High

801790

SEN1
Helicase SEN1

1

0

Small-scale

0.486

High

801791

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

9

Small-scale

0.481

High

488954

SWI6
Regulatory protein SWI6

1

3

High-throughput

0.479

High

518280

IF4A
ATP-dependent RNA helicase eIF4A

1

1

High-throughput

0.479

High

531316

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.479

High

558700

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

682266

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.479

High

704892

KIP2
Kinesin-like protein KIP2

1

2

High-throughput

0.479

High

726990

HS104
Heat shock protein 104

1

4

High-throughput

0.479

High

737845

HOG1
Mitogen-activated protein kinase HOG1

1

5

High-throughput

0.479

High

785912

LONM
Lon protease homolog, mitochondrial

1

3

High-throughput

0.479

High

793568

TBS1
Uncharacterized transcriptional regulatory protein TBS1

1

1

High-throughput

0.479

High

801777

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

801785

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.479

High

801796

SUB2
ATP-dependent RNA helicase SUB2

1

1

High-throughput

0.479

High

801799

DBP10
ATP-dependent RNA helicase DBP10

1

6

High-throughput

0.479

High

801800

CMR1
DNA damage-binding protein CMR1

1

4

High-throughput

0.479

High

637828

MSB1
Morphogenesis-related protein MSB1

1

0

High-throughput

0.458

High

668266

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.458

High

738746

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

0

High-throughput

0.458

High

744529

DRI1
Putative RNA-binding protein involved in heterochromatin assembly

1

0

High-throughput

0.458

High

794740

RTG3
Retrograde regulation protein 3

1

0

High-throughput

0.458

High

801780

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

801793

UBC7
Ubiquitin-conjugating enzyme E2 7

1

3

High-throughput

0.457

High

386694

TBB
Tubulin beta chain

1

1

High-throughput

0.445

High

392666

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.445

High

394514

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

453575

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.445

High

481607

HSP73
Heat shock protein SSA3

1

9

High-throughput

0.445

High

523814

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.445

High

526587

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

544724

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.445

High

592225

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

801775

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.445

High

801778

IMB4
Importin subunit beta-4

1

1

High-throughput

0.445

High

801784

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.445

High

755234

NUF2
Kinetochore protein NUF2

1

5

Small-scale

0.439

High

801797

RLM1
Transcription factor RLM1

1

2

Small-scale

0.439

High

796409

TRM7
tRNA

1

0

High-throughput

0.438

High

706986

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

754205

MSN4
Zinc finger protein MSN4

1

2

High-throughput

0.437

High

794966

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

801776

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

801781

BNI1
Protein BNI1

1

1

High-throughput

0.437

High

801783

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

7

High-throughput

0.437

High

801787

COPA
Coatomer subunit alpha

1

1

High-throughput

0.437

High

801789

H3
Histone H3

1

2

High-throughput

0.437

High

569997

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.426

High

635035

VPS33
Vacuolar protein sorting-associated protein 33

1

0

High-throughput

0.426

High

639012

VPS1
Vacuolar protein sorting-associated protein 1

1

0

High-throughput

0.426

High

684706

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

801802

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.426

High

698104

PEP3
Vacuolar membrane protein PEP3

1

2

High-throughput

0.407

High

779401

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.279

Low

801801

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.279

Low

801794

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

801786

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

0

High-throughput

0.238

Low

382075

H4
Histone H4

1

0

High-throughput

0.232

Low

556604

PEP5
E3 ubiquitin-protein ligase PEP5

1

0

High-throughput

0.232

Low

676922

SRO9
RNA-binding protein SRO9

1

0

High-throughput

0.232

Low

712556

RL8B
Large ribosomal subunit protein eL8B

1

0

High-throughput

0.232

Low

754618

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

0

High-throughput

0.232

Low

801795

RRP5
rRNA biogenesis protein RRP5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025